Search Results - "Sherrell, Darren"

Low‐dose fixed‐target serial synchrotron crystallography by Owen, Robin L., Axford, Danny, Sherrell, Darren A., Kuo, Anling, Ernst, Oliver P., Schulz, Eike C., Miller, R. J. Dwayne, Mueller-Werkmeister, Henrike M.

“…The development of serial crystallography has been driven by the sample requirements imposed by X‐ray free‐electron lasers. Serial techniques are now being…”
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2′-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography by Wilamowski, Mateusz, Sherrell, Darren A., Minasov, George, Kim, Youngchang, Shuvalova, Ludmilla, Lavens, Alex, Chard, Ryan, Maltseva, Natalia, Jedrzejczak, Robert, Rosas-Lemus, Monica, Saint, Nickolaus, Foster, Ian T., Michalska, Karolina, Satchell, Karla J. F., Joachimiak, Andrzej

“…The genome of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus has a capping modification at the 5′-untranslated region (UTR) to…”
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Resolving polymorphs and radiation‐driven effects in microcrystals using fixed‐target serial synchrotron crystallography by Ebrahim, Ali, Appleby, Martin V., Axford, Danny, Beale, John, Moreno-Chicano, Tadeo, Sherrell, Darren A., Strange, Richard W., Hough, Michael A., Owen, Robin L.

“…The ability to determine high‐quality, artefact‐free structures is a challenge in micro‐crystallography, and the rapid onset of radiation damage and…”
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Crystallography on a chip – without the chip: sheet‐on‐sheet sandwich by Doak, R. Bruce, Nass Kovacs, Gabriela, Gorel, Alexander, Foucar, Lutz, Barends, Thomas R. M., Grünbein, Marie Luise, Hilpert, Mario, Kloos, Marco, Roome, Christopher M., Shoeman, Robert L., Stricker, Miriam, Tono, Kensuke, You, Daehyun, Ueda, Kiyoshi, Sherrell, Darren A., Owen, Robin L., Schlichting, Ilme

“…Crystallography chips are fixed‐target supports consisting of a film (for example Kapton) or wafer (for example silicon) that is processed using…”
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Fixed‐target serial crystallography at the Structural Biology Center by Sherrell, Darren A., Lavens, Alex, Wilamowski, Mateusz, Kim, Youngchang, Chard, Ryan, Lazarski, Krzysztof, Rosenbaum, Gerold, Vescovi, Rafael, Johnson, Jessica L., Akins, Chase, Chang, Changsoo, Michalska, Karolina, Babnigg, Gyorgy, Foster, Ian, Joachimiak, Andrzej

“…Serial synchrotron crystallography enables the study of protein structures under physiological temperature and reduced radiation damage by collection of data…”
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Radiation damage and derivatization in macromolecular crystallography: a structure factor's perspective by Owen, Robin L., Sherrell, Darren A.

“…During, or even after, data collection the presence and effects of radiation damage in macromolecular crystallography may not always be immediately obvious…”
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A modular and compact portable mini-endstation for high-precision, high-speed fixed target serial crystallography at FEL and synchrotron sources by Sherrell, Darren A., Foster, Andrew J., Hudson, Lee, Nutter, Brian, O'Hea, James, Nelson, Silke, Paré-Labrosse, Olivier, Oghbaey, Saeed, Miller, R. J. Dwayne, Owen, Robin L.

“…The design and implementation of a compact and portable sample alignment system suitable for use at both synchrotron and free‐electron laser (FEL) sources and…”
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Fixed target combined with spectral mapping: approaching 100% hit rates for serial crystallography by Oghbaey, Saeed, Sarracini, Antoine, Ginn, Helen M., Pare-Labrosse, Olivier, Kuo, Anling, Marx, Alexander, Epp, Sascha W., Sherrell, Darren A., Eger, Bryan T., Zhong, Yinpeng, Loch, Rolf, Mariani, Valerio, Alonso-Mori, Roberto, Nelson, Silke, Lemke, Henrik T., Owen, Robin L., Pearson, Arwen R., Stuart, David I., Ernst, Oliver P., Mueller-Werkmeister, Henrike M., Miller, R. J. Dwayne

“…The advent of ultrafast highly brilliant coherent X‐ray free‐electron laser sources has driven the development of novel structure‐determination approaches for…”
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The HARE chip for efficient time‐resolved serial synchrotron crystallography by Mehrabi, Pedram, Müller-Werkmeister, Henrike M., Leimkohl, Jan-Philipp, Schikora, Hendrik, Ninkovic, Jelena, Krivokuca, Silvia, Andriček, Ladislav, Epp, Sascha W., Sherrell, Darren, Owen, Robin L., Pearson, Arwen R., Tellkamp, Friedjof, Schulz, Eike C., Miller, R. J. Dwayne

“…Serial synchrotron crystallography (SSX) is an emerging technique for static and time‐resolved protein structure determination. Using specifically patterned…”
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Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins by Ebrahim, Ali, Moreno-Chicano, Tadeo, Appleby, Martin V, Chaplin, Amanda K, Beale, John H, Sherrell, Darren A, Duyvesteyn, Helen M E, Owada, Shigeki, Tono, Kensuke, Sugimoto, Hiroshi, Strange, Richard W, Worrall, Jonathan A R, Axford, Danny, Owen, Robin L, Hough, Michael A

“…An approach is demonstrated to obtain, in a sample- and time-efficient manner, multiple dose-resolved crystal structures from room-temperature protein…”
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High-throughput structures of protein-ligand complexes at room temperature using serial femtosecond crystallography by Moreno-Chicano, Tadeo, Ebrahim, Ali, Axford, Danny, Appleby, Martin V, Beale, John H, Chaplin, Amanda K, Duyvesteyn, Helen M E, Ghiladi, Reza A, Owada, Shigeki, Sherrell, Darren A, Strange, Richard W, Sugimoto, Hiroshi, Tono, Kensuke, Worrall, Jonathan A R, Owen, Robin L, Hough, Michael A

“…High-throughput X-ray crystal structures of protein-ligand complexes are critical to pharmaceutical drug development. However, cryocooling of crystals and…”
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Fixed Target Serial Data Collection at Diamond Light Source by Horrell, Sam, Axford, Danny, Devenish, Nicholas E, Ebrahim, Ali, Hough, Michael A, Sherrell, Darren A, Storm, Selina L S, Tews, Ivo, Worrall, Jonathan A R, Owen, Robin L

“…Serial data collection is a relatively new technique for synchrotron users. A user manual for fixed target data collection at I24, Diamond Light Source is…”
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Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature by Moreno-Chicano, Tadeo, Carey, Leiah M, Axford, Danny, Beale, John H, Doak, R Bruce, Duyvesteyn, Helen M E, Ebrahim, Ali, Henning, Robert W, Monteiro, Diana C F, Myles, Dean A, Owada, Shigeki, Sherrell, Darren A, Straw, Megan L, Šrajer, Vukica, Sugimoto, Hiroshi, Tono, Kensuke, Tosha, Takehiko, Tews, Ivo, Trebbin, Martin, Strange, Richard W, Weiss, Kevin L, Worrall, Jonathan A R, Meilleur, Flora, Owen, Robin L, Ghiladi, Reza A, Hough, Michael A

“…Room-temperature macromolecular crystallography allows protein structures to be determined under close-to-physiological conditions, permits dynamic freedom in…”
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Probing the coordination behavior of Hg2+, CH3Hg+, and Cd2+ towards mixtures of two biological thiols by HPLC-ICP-AES by Pei, Katie L, Sooriyaarachchi, Melani, Sherrell, Darren A, George, Graham N, Gailer, Jürgen

“…Hepatocyte cytosol contains a multitude of proteins, but also comparatively high concentrations of l-glutathione (GSH, ~5.0 mM) and L-cysteine (Cys, ~0.5 mM)…”
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Pushing the limits of a beamline endstation by Sherrell, Darren A.

“…Abstract only…”
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Using the ALEX nylon mesh holder for time-resolved serial crystallography: successes and drawbacks by Sherrell, Darren, Wilamowski, Mateusz, Lavens, Alex, Henning, Robert

“…Abstract only…”
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On target: progress in serial crystallography using fixed targets at XFELs and synchrotrons by Axford, Danny, Sherrell, Darren, Owen, Robin L.

“…Abstract only…”
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Data collection from crystals grown in microfluidic droplets by Babnigg, Gyorgy, Sherrell, Darren, Kim, Youngchang, Johnson, Jessica L., Nocek, Boguslaw, Tan, Kemin, Axford, Danny, Li, Hui, Bigelow, Lance, Welk, Lukas, Endres, Michael, Owen, Robin L., Joachimiak, Andrzej

“…Protein crystals grown in microfluidic droplets have been shown to be an effective and robust platform for storage, transport and serial crystallography data…”
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Time-resolved β-lactam cleavage by L1 metallo-β-lactamase by Joachimiak, Andrzej, Wilamowski, Mateusz, Sherrell, Darren, Kim, Youngchang, Lavens, Alex, Henning, Robert, Lazarski, Krzysztof, Endres, Michael, Maltseva, Natalia, Babnigg, Gyorgy, Burdette, Shawn, Srajer, Vukica

“…Abstract only…”
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Serial Synchrotron Cryallography with a Fixed Target by Mueller-Werkmeister, Henrike M., Schulz, Eike C., Sherrell, Darren, Axford, Danny, Tellkamp, Friedjof, Owen, Robin L., Dwayne Miller, R.J.

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