Search Results - "Sherpa, Chringma"

Structural Fluidity of the Human Immunodeficiency Virus Rev Response Element by Sherpa, Chringma, Grice, Stuart F J Le

“…Nucleocytoplasmic transport of unspliced and partially spliced human immunodeficiency virus (HIV) RNA is mediated in part by the Rev response element (RRE), a…”
Get full text

Structural characterization of maternally expressed gene 3 RNA reveals conserved motifs and potential sites of interaction with polycomb repressive complex 2 by Sherpa, Chringma, Rausch, Jason W, Le Grice, Stuart FJ

“…Abstract Long non-coding RNAs (lncRNAs) have emerged as key players in gene regulation. However, our incomplete understanding of the structure of lncRNAs has…”
Get full text

Characterizing and circumventing sequence restrictions for synthesis of circular RNA in vitro by Rausch, Jason W, Heinz, William F, Payea, Matthew J, Sherpa, Chringma, Gorospe, Myriam, Le Grice, Stuart F J

“…Abstract Just as eukaryotic circular RNA (circRNA) is a product of intracellular backsplicing, custom circRNA can be synthesized in vitro using a transcription…”
Get full text

The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication by Sherpa, Chringma, Rausch, Jason W, Le Grice, Stuart F J, Hammarskjold, Marie-Louise, Rekosh, David

“…The HIV Rev protein forms a complex with a 351 nucleotide sequence present in unspliced and incompletely spliced human immunodeficiency virus (HIV) mRNAs, the…”
Get full text

Molecular recognition of a branched peptide with HIV-1 Rev Response Element (RRE) RNA by Dai, Yumin, Peralta, Ashley N., Wynn, Jessica E., Sherpa, Chringma, Li, Hao, Verma, Astha, Le Grice, Stuart F.J., Santos, Webster L.

“…[Display omitted] Interaction of HIV-1 rev response element (RRE) RNA with its cognate protein, Rev, is critical for HIV-1 replication. Understanding the mode…”
Get full text

Evolution of the HIV-1 Rev Response Element during Natural Infection Reveals Nucleotide Changes That Correlate with Altered Structure and Increased Activity over Time by Sherpa, Chringma, Jackson, Patrick E H, Gray, Laurie R, Anastos, Kathryn, Le Grice, Stuart F J, Hammarskjold, Marie-Louise, Rekosh, David

“…The HIV-1 Rev response element (RRE) is a -acting RNA element characterized by multiple stem-loops. Binding and multimerization of the HIV Rev protein on the…”
Get full text

Discovery of a Branched Peptide That Recognizes the Rev Response Element (RRE) RNA and Blocks HIV‑1 Replication by Dai, Yumin, Wynn, Jessica E, Peralta, Ashley N, Sherpa, Chringma, Jayaraman, Bhargavi, Li, Hao, Verma, Astha, Frankel, Alan D, Le Grice, Stuart F, Santos, Webster L

“…We synthesized and screened a unique 46 656-member library composed of unnatural amino acids that revealed several hits against RRE IIB RNA. Among the hit…”
Get full text

Molecular recognition of HIV-1 RNAs with branched peptides by Peralta, Ashley N, Dai, Yumin, Sherpa, Chringma, Le Grice, Stuart F J, Santos, Webster L

“…Targeting RNA offers the potential in many diseases of a therapeutic treatment. Due to its large surface area and ability to adopt different conformations,…”
Get more information

An Evolved RNA Recognition Motif That Suppresses HIV‑1 Tat/TAR-Dependent Transcription by Crawford, David W, Blakeley, Brett D, Chen, Po-Han, Sherpa, Chringma, Le Grice, Stuart F.J, Laird-Offringa, Ite A, McNaughton, Brian R

“…Potent and selective recognition and modulation of disease-relevant RNAs remain a daunting challenge. We previously examined the utility of the U1A N-terminal…”
Get full text