Search Results - "Sherman, Vanessa"

Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability by Staas, Donnette D., Savage, Kelly L., Sherman, Vanessa L., Shimp, Heidi L., Lyle, Terry A., Tran, Lekhanh O., Wiscount, Catherine M., McMasters, Daniel R., Sanderson, Philip E.J., Williams, Peter D., Lucas, Bobby J., Krueger, Julie A., Dale Lewis, S., White, Rebecca B., Yu, Sean, Wong, Bradley K., Kochansky, Christopher J., Reza Anari, M., Yan, Youwei, Vacca, Joseph P.

“…Previous reports from our laboratories described potent tripeptide thrombin inhibitors which incorporate heterocycle-substituted chlorophenyl groups in the P1…”
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10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3- d]pyridazine-1,9(2 H,6 H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants by Wiscount, Catherine M., Williams, Peter D., Tran, Lekhanh O., Embrey, Mark W., Fisher, Thorsten E., Sherman, Vanessa, Homnick, Carl F., Donnette Staas, D., Lyle, Terry A., Wai, John S., Vacca, Joseph P., Wang, ZiQiang, Felock, Peter J., Stillmock, Kara A., Witmer, Marc V., Miller, Michael D., Hazuda, Daria J., Day, Alysha M., Gabryelski, Lori J., Ecto, Linda T., Schleif, William A., DiStefano, Daniel J., Kochansky, Christopher J., Reza Anari, M.

“…[Display omitted] A series of 10-hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3- d]pyridazine-1,9(2 H,6 H)-diones was synthesized and tested for their…”
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