Search Results - "Sherman, Nicholas"
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Proteomic analysis of cattle tick Rhipicephalus (Boophilus) microplus saliva: a comparison between partially and fully engorged females
Published in PloS one (01-04-2014)“…The cattle tick Rhipicephalus (Boophilus) microplus is one of the most harmful parasites affecting bovines. Similarly to other hematophagous ectoparasites, R…”
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Towards an arthritis flare-responsive drug delivery system
Published in Nature communications (03-04-2018)“…Local delivery of therapeutics for the treatment of inflammatory arthritis (IA) is limited by short intra-articular half-lives. Since IA severity often…”
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Spatiotemporal Crossover between Low- and High-Temperature Dynamical Regimes in the Quantum Heisenberg Magnet
Published in Physical review letters (03-09-2021)“…The stranglehold of low temperatures on fascinating quantum phenomena in one-dimensional quantum magnets has been challenged recently by the discovery of…”
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Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9
Published in Molecular cell (18-05-2017)“…ADP-ribosylation of proteins is emerging as an important regulatory mechanism. Depending on the family member, ADP-ribosyltransferases either conjugate a…”
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S6K1- and βTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth
Published in Science (American Association for the Advancement of Science) (20-10-2006)“…The tumor suppressor programmed cell death protein 4 (PDCD4) inhibits the translation initiation factor eIF4A, an RNA helicase that catalyzes the unwinding of…”
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Characterization of a novel AraC/XylS-regulated family of N-acyltransferases in pathogens of the order Enterobacterales
Published in PLoS pathogens (01-08-2020)“…Enteroaggregative Escherichia coli (EAEC) is a diarrheagenic pathotype associated with traveler's diarrhea, foodborne outbreaks and sporadic diarrhea in…”
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Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs
Published in The Journal of experimental medicine (01-08-2022)“…Rap1 GTPase drives assembly of the Mig-10/RIAM/Lamellipodin (MRL protein)-integrin-talin (MIT) complex that enables integrin-dependent lymphocyte functions…”
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Towards a defined ECM and small molecule based monolayer culture system for the expansion of mouse and human intestinal stem cells
Published in Biomaterials (01-02-2018)“…Current ISC culture systems face significant challenges such as animal-derived or undefined matrix compositions, batch-to-batch variability (e.g…”
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Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly
Published in Nature communications (11-05-2021)“…Androgen signaling through the androgen receptor (AR) directs gene expression in both normal and prostate cancer cells. Androgen regulates multiple aspects of…”
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Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis
Published in PloS one (18-05-2012)“…Tumor cells in vivo encounter diverse types of microenvironments both at the site of the primary tumor and at sites of distant metastases. Understanding how…”
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Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function
Published in Proceedings of the National Academy of Sciences - PNAS (24-03-2009)“…Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals…”
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LMO7 deficiency reveals the significance of the cuticular plate for hearing function
Published in Nature communications (08-03-2019)“…Sensory hair cells, the mechanoreceptors of the auditory and vestibular systems, harbor two specialized elaborations of the apical surface, the hair bundle and…”
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Molecular architecture of the chick vestibular hair bundle
Published in Nature neuroscience (01-03-2013)“…In this Resource study, the authors used high-resolution mass spectrometry to elucidate the precise proteomic complement of the inner ear hair bundle. Many of…”
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14
Accurate Label-Free Protein Quantitation with High- and Low-Resolution Mass Spectrometers
Published in Journal of proteome research (07-02-2014)“…Label-free quantitation of proteins analyzed by tandem mass spectrometry uses either integrated peak intensity from the parent-ion mass analysis (MS1) or…”
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Archaeal flagellin combines a bacterial type IV pilin domain with an Ig-like domain
Published in Proceedings of the National Academy of Sciences - PNAS (13-09-2016)“…The bacterial flagellar apparatus, which involves ∼40 different proteins, has been a model system for understanding motility and chemotaxis. The bacterial…”
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Characterization of the interactome profiling of Mycoplasma fermentans DnaK in cancer cells reveals interference with key cellular pathways
Published in Frontiers in microbiology (28-10-2022)“…Chaperone proteins are redundant in nature and, to achieve their function, they bind a large repertoire of client proteins. DnaK is a bacterial chaperone…”
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Towards improving proximity labeling by the biotin ligase BirA
Published in Methods (San Diego, Calif.) (15-03-2019)“…[Display omitted] •Screened for substitutions in the biotin binding site that modulate BirA activity.•An Arg-to-Lys substitution at position 118 increases…”
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DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination
Published in Cell reports (Cambridge) (19-03-2019)“…The control of p53 protein stability is critical to its tumor suppressor functions. The CREB binding protein (CBP) transcriptional co-activator co-operates…”
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Observation of Bothrops atrox Snake Envenoming Blister Formation from Five Patients: Pathophysiological Insights
Published in Toxins (13-11-2021)“…In the Brazilian Amazon, snakebites are frequent, and patients develop tissue damage with blisters sometimes observed in the proximity of the wound. Antivenoms…”
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Proteomic analysis of the cyst stage of Entamoeba histolytica
Published in PLoS neglected tropical diseases (01-05-2012)“…The category B agent of bioterrorism, Entamoeba histolytica has a two-stage life cycle: an infective cyst stage, and an invasive trophozoite stage. Due to our…”
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