Search Results - "Sherman, M.Y."

Adjuvant potential of aggregate-forming polyglutamine domains by Ilyinskii, P.O, Thoidis, G, Sherman, M.Y, Shneider, A

“…Abstract Aggregation may significantly affect the fate of a polypeptide, including its susceptibility to proteasome-dependent or autophagic degradation, its…”
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Hsp70 in cancer: back to the future by Sherman, M Y, Gabai, V L

“…Mechanistic studies from cell culture and animal models have revealed critical roles for the heat shock protein Hsp70 in cancer initiation and progression…”
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Hsp70-Bag3 Interactions Regulate Cancer-Related Signaling Networks by COLVIN, Teresa A, GABAI, Vladimir L, GARCIA-MARCOS, Mikel, XIAOKAI LI, YOUNG, Z. T, RAUCH, Jennifer N, GESTWICKI, Jason E, TAKAYAMA, Shinichi, SHERMAN, Michael Y, JIANLIN GONG, CALDERWOOD, Stuart K, HU LI, GUMMULURU, Suryaram, MATCHUK, Olga N, SMIRNOVA, Svetlana G, ORLOVA, Nina V, ZAMULAEVA, Irina A

“…Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in cell signaling. Here, we report that Bag3 interacts with the SH3…”
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Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis by Meng, L, Gabai, V L, Sherman, M Y

“…The heat-shock transcription factor HSF1 was recently shown to have a key role in the development of tumors associated with activation of Ras or inactivation…”
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New somatostatin-drug conjugates for effective targeting pancreatic cancer by Ragozin, E., Hesin, A., Bazylevich, A., Tuchinsky, H., Bovina, A., Shekhter Zahavi, T., Oron-Herman, M., Kostenich, G., Firer, M.A., Rubinek, T., Wolf, I., Luboshits, G., Sherman, M.Y., Gellerman, G.

“…[Display omitted] •New cyclic peptide-drug conjugates for effective targeting pancreatic cancer were discovered.•These conjugates comprising cyclic peptides…”
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Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis by Meng, L, Hunt, C, Yaglom, J A, Gabai, V L, Sherman, M Y

“…The major heat shock protein Hsp72 is expressed at elevated levels in many human cancers and its expression correlates with tumor progression. Here, we…”
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ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis by Bergholz, J, Zhang, Y, Wu, J, Meng, L, Walsh, E M, Rai, A, Sherman, M Y, Jim Xiao, Z-X

“…Reduced expression of the p53 family member p63 has been suggested to play a causative role in cancer metastasis. Here, we show that ΔNp63α, the predominant…”
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HSP72 depletion suppresses γH2AX activation by genotoxic stresses via p53 p21 signaling by Gabai, V L, Sherman, M Y, Yaglom, J A

“…Knockout of heat shock protein Hsp72 was shown to promote chromosomal instability and increase radiation sensitivity of mouse fibroblasts. Here, we report that…”
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Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis by Gong, J, Weng, D, Eguchi, T, Murshid, A, Sherman, M Y, Song, B, Calderwood, S K

“…Elevated levels of the inducible heat-shock protein 70 (Hsp72) have been implicated in mammary tumorigenesis in histological investigations of human breast…”
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