Search Results - "Sherman, Larry S"
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Diverse Roles for Hyaluronan and Hyaluronan Receptors in the Developing and Adult Nervous System
Published in International journal of molecular sciences (20-08-2020)“…Hyaluronic acid (HA) plays a vital role in the extracellular matrix of neural tissues. Originally thought to hydrate tissues and provide mechanical support, it…”
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Emerging roles of hyaluronic acid bioscaffolds in tissue engineering and regenerative medicine
Published in International journal of biological macromolecules (01-05-2016)“…Hyaluronic acid (HA), is a glycosaminoglycan comprised of repeating disaccharide units of N-acetyl-d-glucosamine and d-glucuronic acid. HA is synthesized by…”
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Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants
Published in Annals of neurology (01-01-2012)“…Objective: The major form of magnetic resonance imaging–defined white matter injury (WMI) comprises diffuse lesions where the burden of small necrotic foci…”
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Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury
Published in Annals of neurology (01-04-2008)“…Objective Abnormal myelination is a major pathological sequela of chronic periventricular white matter injury in survivors of premature birth. We tested the…”
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A novel non-human primate model of Pelizaeus-Merzbacher disease
Published in Neurobiology of disease (01-10-2021)“…Pelizaeus-Merzbacher disease (PMD) is a severe hypomyelinating disorder of the central nervous system (CNS) linked to mutations in the proteolipid protein-1…”
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Creatine Metabolism in Female Reproduction, Pregnancy and Newborn Health
Published in Nutrients (01-02-2021)“…Creatine metabolism is an important component of cellular energy homeostasis. Via the creatine kinase circuit, creatine derived from our diet or synthesized…”
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Discovery of a CLN7 model of Batten disease in non-human primates
Published in Neurobiology of disease (01-11-2018)“…We have identified a natural Japanese macaque model of the childhood neurodegenerative disorder neuronal ceroid lipofuscinosis, commonly known as Batten…”
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Postischemic Infusion of Apigenin Reduces Seizure Burden in Preterm Fetal Sheep
Published in International journal of molecular sciences (01-12-2023)“…Seizures are common in preterm newborns and are associated with poor neurodevelopmental outcomes. Current anticonvulsants have poor efficacy, and many have…”
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Digestion products of the PH20 hyaluronidase inhibit remyelination
Published in Annals of neurology (01-02-2013)“…Objective Oligodendrocyte progenitor cells (OPCs) recruited to demyelinating lesions often fail to mature into oligodendrocytes (OLs) that remyelinate spared…”
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White matter lesions defined by diffusion tensor imaging in older adults
Published in Annals of neurology (01-09-2011)“…Objective: The cellular and molecular mechanisms underlying magnetic resonance imaging‐defined white matter (WM) changes associated with age‐related cognitive…”
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Brg1 directly regulates Olig2 transcription and is required for oligodendrocyte progenitor cell specification
Published in Developmental biology (15-05-2016)“…The Olig2 basic-helix-loop-helix transcription factor promotes oligodendrocyte specification in early neural progenitor cells (NPCs), including radial glial…”
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Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria
Published in American journal of medical genetics. Part A (01-03-2013)“…Schwannomatosis is the third major form of neurofibromatosis and is characterized by the development of multiple schwannomas in the absence of bilateral…”
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Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases
Published in International Journal of Cell Biology (2015)“…The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating neural differentiation, survival,…”
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Astrocytes in aged nonhuman primate brain gray matter synthesize excess hyaluronan
Published in Neurobiology of aging (01-04-2012)“…Abstract The glycosaminoglycan hyaluronan (HA) accumulates in central nervous system lesions where it limits astrogliosis but also inhibits oligodendrocyte…”
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Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism
Published in eLife (23-12-2020)“…Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive form of ovarian cancer. SCCOHT tumors have inactivating mutations in…”
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CD44 is required for spatial memory retention and sensorimotor functions
Published in Behavioural brain research (15-12-2014)“…•CD44 null mice exhibited memory retention deficits in the Morris water maze task.•CD44 null mice exhibited sensorimotor deficits in some tests.•CD44 is…”
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FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice
Published in Human molecular genetics (15-03-2007)“…Rett syndrome (RTT) is an X-linked neurodevelopmental disorder linked to heterozygous de novo mutations in the MECP2 gene. MECP2 encodes methyl-CpG-binding…”
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Role of recurrent hypoxia-ischemia in preterm white matter injury severity
Published in PloS one (12-11-2014)“…Although the spectrum of white matter injury (WMI) in preterm infants is shifting from cystic necrotic lesions to milder forms, the factors that contribute to…”
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Multispectral LEDs Eliminate Lipofuscin-Associated Autofluorescence for Immunohistochemistry and CD44 Variant Detection by in Situ Hybridization in Aging Human, non-Human Primate, and Murine Brain
Published in ASN neuro (2022)“…A major limitation of mechanistic studies in aging brains is the lack of routine methods to robustly visualize and discriminate the cellular distribution of…”
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Hyaluronan Anchored to Activated CD44 on Central Nervous System Vascular Endothelial Cells Promotes Lymphocyte Extravasation in Experimental Autoimmune Encephalomyelitis
Published in The Journal of biological chemistry (28-09-2012)“…The extravasation of lymphocytes across central nervous system (CNS) vascular endothelium is a key step in inflammatory demyelinating diseases including…”
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