Search Results - "Sherman, LS"

White matter penetrating arteriole dysfunction correlates with MRI-defined white matter integrity in patients with Alzheimer's disease by Bagi, ZSOLT, Kroenke, C, Keene, CD, Sherman, LS, Back, SA

“…Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): National Institute of Health Objectives Patients with…”
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Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation by Sherman, Larry S, Back, Stephen A, Tuohy, Therese M F, Chen, Hanqin, Wallingford, Nicholas, Craig, Andrew, Struve, Jaime, Luo, Ning Ling, Banine, Fatima, Liu, Ying, Chang, Ansi, Trapp, Bruce D, Bebo, Bruce F, Rao, Mahendra S

“…Demyelination is the hallmark of numerous neurodegenerative conditions, including multiple sclerosis. Oligodendrocyte progenitors (OPCs), which normally mature…”
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Abstract P1-06-07: Msi1 in maintaining breast cancer stem cell involves the AKT/PI3K pathway by Nahas, GR, Sinha, GA, Sherman, LS, Walker, ND, Rameshwar, P

“…Abstract Musashi1 (Msi1) was originally described in neural stem cells in a role influencing neural differentiation in the Numb/Notch pathway. Due to its role…”
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The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44 by Morrison, H, Sherman, L S, Legg, J, Banine, F, Isacke, C, Haipek, C A, Gutmann, D H, Ponta, H, Herrlich, P

“…The neurofibromatosis-2 (NF2) gene encodes merlin, an ezrin-radixin-moesin-(ERM)-related protein that functions as a tumor suppressor. We found that merlin…”
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From process to progress—2017 International Conference on Neurofibromatosis 1, Neurofibromatosis 2 and Schwannomatosis by Ferner, Rosalie E., Bakker, Annette, Elgersma, Ype, Evans, D. Gareth R., Giovannini, Marco, Legius, Eric, Lloyd, Alison, Messiaen, Ludwine M., Plotkin, Scott, Reilly, Karlyne M., Schindeler, Aaron, Smith, Miriam J., Ullrich, Nicole J., Widemann, Brigitte, Sherman, Larry S.

“…The neurofibromatoses are inherited, tumor suppressor disorders that are characterized by multiple, benign peripheral nerve sheath tumors and other nervous…”
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Brg1 is required for murine neural stem cell maintenance and gliogenesis by Matsumoto, Steven, Banine, Fatima, Struve, Jaime, Xing, Rubing, Adams, Chris, Liu, Ying, Metzger, Daniel, Chambon, Pierre, Rao, Mahendra S., Sherman, Larry S.

“…Epigenetic alterations in cell-type-specific gene expression control the transition of neural stem cells (NSCs) from predominantly neurogenic to predominantly…”
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CD44 expression identifies astrocyte-restricted precursor cells by Liu, Ying, Han, Steve S.W., Wu, Yuanyuan, Tuohy, Therese M.F., Xue, Haipeng, Cai, Jingli, Back, Stephen A., Sherman, Larry S., Fischer, Itzhak, Rao, Mahendra S.

“…The precise lineage between neural stem cells and mature astrocytes remains poorly defined. To examine astrocyte development, we have characterized glial…”
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SWI/SNF chromatin-remodeling factors induce changes in DNA methylation to promote transcriptional activation by BANINE, Fatima, BARTLEN, Christopher, GUNAWARDENA, Ranjaka, MUCHARDT, Christian, YANIV, Moshe, KNUDSEN, Erik S, WEISSMAN, Bernard E, SHERMAN, Larry S

“…Brahma (Brm) and brahma-related gene-1 (Brg1) are mammalian homologues of SWI/SNF chromatin-remodeling factor subunits that can regulate both transcriptional…”
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Coordinate control of axon defasciculation and myelination by laminin-2 and -8 by Yang, Dongren, Bierman, Jesse, Tarumi, Yukie S, Zhong, Yong-Ping, Rangwala, Reshma, Proctor, Thomas M, Miyagoe-Suzuki, Yuko, Takeda, Shin'ichi, Miner, Jeffrey H, Sherman, Larry S, Gold, Bruce G, Patton, Bruce L

“…Schwann cells form basal laminae (BLs) containing laminin-2 (Ln-2; heterotrimer [alpha]2{szligbeta}1[gamma]1) and Ln-8 ([alpha]4{szligbeta}1[gamma]1). Loss of…”
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Disruption of the hyaluronan-based extracellular matrix in spinal cord promotes astrocyte proliferation by Struve, Jaime, Maher, P. Colby, Li, Ya-qin, Kinney, Shawn, Fehlings, Michael G., Kuntz IV, Charles, Sherman, Larry S.

“…Astrocyte proliferation is tightly controlled during development and in the adult nervous system. In the present study, we find that a high‐molecular‐weight…”
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Erbin Regulates Mitogen-activated Protein (MAP) Kinase Activation and MAP Kinase-dependent Interactions between Merlin and Adherens Junction Protein Complexes in Schwann Cells by Rangwala, Reshma, Banine, Fatima, Borg, Jean-Paul, Sherman, Larry S.

“…Biallelic mutations in the neurofibromatosis 2 (NF2) gene are linked to schwannoma and meningioma tumorigenesis. Cells with NF2 mutations exhibit elevated…”
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Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression by REISMAN, David N, STROBECK, Matthew W, BETZ, Bryan L, SCIARIOTTA, Janiece, FUNKHOUSER, William JR, MURCHARDT, Christian, YANIV, Moshe, SHERMAN, Larry S, KNUDSEN, Erik S, WEISSMAN, Bernard E

“…Mammalian cells express two homologs of the SWI2 subunit of the SWI/SNF chromatin-remodeling complex called BRG1 and BRM. Whether the SWI/SNF complexes formed…”
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CD44 Enhances Neuregulin Signaling by Schwann Cells by Sherman, Larry S., Rizvi, Tilat A., Karyala, Saikumar, Ratner, Nancy

“…We describe a key role for the CD44 transmembrane glycoprotein in Schwann cell-neuron interactions. CD44 proteins have been implicated in cell adhesion and in…”
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Single Cell Ras-GTP Analysis Reveals Altered Ras Activity in a Subpopulation of Neurofibroma Schwann Cells but Not Fibroblasts by Sherman, Larry S., Atit, Radhika, Rosenbaum, Thorsten, Cox, Adrienne D., Ratner, Nancy

“…Neurofibromatosis type 1 (NF1) is a common genetic disorder characterized by multiple neurofibromas, peripheral nerve tumors containing mainly Schwann cells…”
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The BRG-1 Subunit of the SWI/SNF Complex Regulates CD44 Expression by Strobeck, Matthew W., DeCristofaro, Marc F., Banine, Fatima, Weissman, Bernard E., Sherman, Larry S., Knudsen, Erik S.

“…Aberrant regulation of CD44, a transmembrane glycoprotein, has been implicated in the growth and metastasis of numerous tumors. Although both CD44…”
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CD44 overexpression by oligodendrocytes: A novel mouse model of inflammation‐independent demyelination and dysmyelination by Tuohy, Therese M.F., Wallingford, Nicholas, Liu, Ying, Chan, Frank H., Rizvi, Tilat, Xing, Rubing, Bebo, Bruce, Rao, Mahendra S., Sherman, Larry S.

“…The CD44 transmembrane glycoprotein family has been implicated in cell‐cell adhesion and cell signaling in response to components of the extracellular matrix…”
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Merlin: hanging tumor suppression on the Rac by Sherman, L S, Gutmann, D H

“…Cancer can result from any number of abnormalities in the control of cell-cycle progression, intracellular signaling and transduction of extracellular cues…”
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Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells by PELTON, P. D, SHERMAN, L. S, RIZVI, T. A, MARCHIONNI, M. A, WOOD, P, FRIEDMAN, R. A, RATNER, N

“…Schwannomas are peripheral nerve tumors that typically have mutations in the NF2 tumor suppressor gene. We compared cultured schwannoma cells with Schwann…”
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Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation by KUNS, Robin, KISSIL, Joseph L, NEWSHAM, Irene F, JACKS, Tyler, GUTMANN, David H, SHERMAN, Larry S

“…4.1B is a member of the protein 4.1 superfamily of proteins that link transmembrane proteins to the actin cytoskeleton. The 4.1B gene localizes to chromosome…”
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Renal masses: assessment of corticomedullary-phase and nephrographic-phase CT scans by Cohan, R H, Sherman, L S, Korobkin, M, Bass, J C, Francis, I R

“…To evaluate the role of thin-section helical computed tomography (CT) performed during the corticomedullary phase (CMP) and nephrographic phase (NP) of…”
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