Search Results - "Sherman, Julian"

Xanthine oxidase levels and immune dysregulation are independently associated with anemia in Plasmodium falciparum malaria by Vasquez, Marilyn, Sica, Margaux, Namazzi, Ruth, Opoka, Robert O., Sherman, Julian, Datta, Dibyadyuti, Duran-Frigola, Miquel, Ssenkusu, John M., John, Chandy C., Conroy, Andrea L., Rodriguez, Ana

“…Severe anemia is an important contributor to mortality in children with severe malaria. Anemia in malaria is a multi-factorial complication, since…”
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Discovery of Strong 3-Nitro-2-Phenyl- 2H -Chromene Analogues as Antitrypanosomal Agents and Inhibitors of Trypanosoma cruzi Glucokinase by Carey, Shane M, O'Neill, Destiny M, Conner, Garrett B, Sherman, Julian, Rodriguez, Ana, D'Antonio, Edward L

“…Chagas disease is one of the world's neglected tropical diseases, caused by the human pathogenic protozoan parasite . There is currently a lack of effective…”
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Tamoxifen activity against Plasmodium in vitro and in mice by Weinstock, Ada, Gallego-Delgado, Julio, Gomes, Cláudia, Sherman, Julian, Nikain, Cyrus, Gonzalez, Sandra, Fisher, Edward, Rodriguez, Ana

“…Tamoxifen is an oestrogen receptor modulator that is widely used for the treatment of early stage breast cancer and reduction of recurrences. Tamoxifen is also…”
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Anti- Trypanosoma cruzi Activity of Metabolism Modifier Compounds by Martinez-Peinado, Nieves, Martori, Clara, Cortes-Serra, Nuria, Sherman, Julian, Rodriguez, Ana, Gascon, Joaquim, Alberola, Jordi, Pinazo, Maria-Jesus, Rodriguez-Cortes, Alheli, Alonso-Padilla, Julio

“…Chagas disease is caused by the protozoan parasite and affects over 6 million people worldwide. Development of new drugs to treat this disease remains a…”
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Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates by Obermann, Wiebke, Azri, Mohammad Farhan Darin, Konopka, Leonie, Schmidt, Nina, Magari, Francesca, Sherman, Julian, Silva, Liliana M. R., Hermosilla, Carlos, Ludewig, Andreas H., Houhou, Hicham, Haeberlein, Simone, Luo, Mona Yiting, Häcker, Irina, Schetelig, Marc F., Grevelding, Christoph G., Schroeder, Frank C., Lau, Gilbert Sei Kung, Taubert, Anja, Rodriguez, Ana, Heine, Andreas, Yeo, Tiong Chia, Grünweller, Arnold, Taroncher-Oldenburg, Gaspar

“…Inhibition of eukaryotic initiation factor 4A has been proposed as a strategy to fight pathogens. Rocaglates exhibit the highest specificities among eIF4A…”
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Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections by Rivera-Correa, Juan, Verdi, Joseph, Sherman, Julian, Sternberg, Jeremy M, Raper, Jayne, Rodriguez, Ana

“…Anemia caused by trypanosome infection is poorly understood. Autoimmunity during Trypanosoma brucei infection was proposed to have a role during anemia, but…”
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Identification of Trypanosoma cruzi Growth Inhibitors with Activity In Vivo within a Collection of Licensed Drugs by Martinez-Peinado, Nieves, Cortes-Serra, Nuria, Sherman, Julian, Rodriguez, Ana, Bustamante, Juan M, Gascon, Joaquim, Pinazo, Maria-Jesus, Alonso-Padilla, Julio

“…Chagas disease, caused by the parasite , affects more than six million people worldwide, with its greatest burden in Latin America. Available treatments…”
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Discovery of Strong 3-Nitro-2-Phenyl-I2H/I-Chromene Analogues as Antitrypanosomal Agents and Inhibitors of ITrypanosoma cruzi/I Glucokinase by Carey, Shane M, O’Neill, Destiny M, Conner, Garrett B, Sherman, Julian, Rodriguez, Ana, D’Antonio, Edward L

“…Chagas disease is one of the world’s neglected tropical diseases, caused by the human pathogenic protozoan parasite Trypanosoma cruzi. There is currently a…”
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Circulating immune complexes and G6PD deficiency predict readmissions for blackwater fever and severe anemia in children with severe malaria in Eastern Uganda by Namazzi, Ruth, Mellencamp, Kagan A, Opoka, Robert O, Datta, Dibyadyuti, Lima-Cooper, Giselle, Liepmann, Claire, Sherman, Julian, Rodriguez, Ana, Kazinga, Caroline, Ware, Russell E, Goings, Michael G, Lacerda, Marcus, Abreu, Marco, Schwantes-An, Tae-Hwi, John, Chandy C, Conroy, Andrea L

“…Recently, there has been an unexplained increase in the incidence of blackwater fever (BWF) in Eastern Uganda. In this study, we evaluate the association…”
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Circulating Immune Complexes and Glucose-6-Phosphate Dehydrogenase Deficiency Predict Recurrent Blackwater Fever in Ugandan Children With Severe Malaria by Namazzi, Ruth, Mellencamp, Kagan A, Opoka, Robert O, Datta, Dibyadyuti, Lima-Cooper, Giselle, Liepmann, Claire, Sherman, Julian, Rodriguez, Ana, Kazinga, Caroline, Ware, Russell E, Goings, Michael G, Lacerda, Marcus, Abreu, Marco, Schwantes-An, Tae-Hwi, John, Chandy C, Conroy, Andrea L

“…Abstract Background Recently, there has been an unexplained increase in the incidence of blackwater fever (BWF) in Eastern Uganda. In this study, we evaluated…”
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Novel Diarylthioether Compounds as Agents for the Treatment of Chagas Disease by Beveridge, Julia, Tran, Eric, Deora, Girdhar Singh, Huang, Fei, Wang, Yuzhi, Stockton, Kieran, Cotillo, Ignacio, Martinez Martinez, Maria Santos, Gonzalez, Silvia, Castañeda, Pablo, Sherman, Julian, Rodriguez, Ana, Kessler, Albane, Baell, Jonathan B.

“…Herein, we describe the hit optimization of a novel diarylthioether chemical class found to be active against Trypanosoma cruzi; the parasite responsible for…”
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Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance by Zhan, Wenhu, Li, Daqiang, Subramanyaswamy, Shubha Bevkal, Liu, Yi Jing, Yang, Changmei, Zhang, Hao, Harris, Jacob C, Wang, Rong, Zhu, Songbiao, Rocha, Hedy, Sherman, Julian, Qin, Junling, Herring, Mikayla, Simwela, Nelson V, Waters, Andrew P, Sukenick, George, Cui, Liwang, Rodriguez, Ana, Deng, Haiteng, Nathan, Carl F, Kirkman, Laura A, Lin, Gang

“…Artemisinins (ART) are critical anti-malarials and despite their use in combination therapy, ART-resistant Plasmodium falciparum is spreading globally. To…”
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Synthesis, biochemical, and biological evaluation of C2 linkage derivatives of amino sugars, inhibitors of glucokinase from Trypanosoma cruzi by Green, Scott B., Lanier, Robert J., Carey, Shane M., Morgan, David R., Gracz, Hanna, Sherman, Julian, Rodriguez, Ana, D'Antonio, Edward L.

“…[Display omitted] •Novel amino sugar analogues were synthesized and purified in a one-step method.•Eighteen amino sugar analogues having either a d-GlcN,…”
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Design, synthesis, and evaluation of substrate – analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B by Gonzalez, Soledad Natalia, Mills, Jonathan J., Maugeri, Dante, Olaya, Christopher, Laguera, Breana L., Enders, Jeffrey R., Sherman, Julian, Rodriguez, Ana, Pierce, Joshua G., Cazzulo, Juan José, D'Antonio, Edward L.

“…[Display omitted] Ribose 5-phosphate isomerase type B (RPI-B) is a key enzyme of the pentose phosphate pathway that catalyzes the isomerization of ribose…”
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Discovery of Potent N‑Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi by Varghese, Swapna, Rahmani, Raphaël, Russell, Stephanie, Deora, Girdhar Singh, Ferrins, Lori, Toynton, Arthur, Jones, Amy, Sykes, Melissa, Kessler, Albane, Eufrásio, Amanda, Cordeiro, Artur Torres, Sherman, Julian, Rodriguez, Ana, Avery, Vicky M, Piggott, Matthew J, Baell, Jonathan B

“…Trypanosoma brucei (T. brucei) and Trypanosoma cruzi (T. cruzi) are causative agents of parasitic diseases known as human African trypanosomiasis and Chagas…”
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