Search Results - "Sherlock, Alexandra E"

Enantioselective Total Syntheses of Omuralide, 7-epi-Omuralide, and (+)-Lactacystin by Hayes, Christopher J, Sherlock, Alexandra E, Green, Martin P, Wilson, Claire, Blake, Alexander J, Selby, Matthew D, Prodger, Jeremy C

“…An alkylidene carbene 1,5-CH insertion has been used as a key step in an enantioselective total syntheses of omuralide, its C7-epimer, and (+)-lactacystin. An…”
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Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor by Gillmore, Adam T, Badland, Matthew, Crook, Clare L, Castro, Nieves M, Critcher, Douglas J, Fussell, Steven J, Jones, Katherine J, Jones, Matthew C, Kougoulos, Eleftherios, Mathew, Jinu S, McMillan, Lynne, Pearce, John E, Rawlinson, Fiona L, Sherlock, Alexandra E, Walton, Robert

“…Novel PARP inhibitor 1 is a promising new candidate for treatment of breast and ovarian cancer. A modified synthetic route to 1 has been developed and…”
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Enantioselective total syntheses of (-)-clasto-lactacystin beta-lactone and 7-epi-(-)-clasto-lactacystin beta-lactone by Hayes, Christopher J, Sherlock, Alexandra E, Selby, Matthew D

“…An alkylidene carbene 1,5-CH insertion has been used as a key step in an efficient enantioselective total synthesis of (-)-clasto-lactacystin beta-lactone, and…”
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A Convenient Method for 3-Pyrroline Synthesis by Green, Martin P, Prodger, Jeremy C, Sherlock, Alexandra E, Hayes, Christopher J

“…The synthesis of a range of 3-pyrrolines has been achieved from primary amine starting materials using a two-step alkylation/alkylidene carbene CH-insertion…”
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Studies on DMDO-mediated benzylidene acetal oxidation by Mycock, David K., Sherlock, Alexandra E., Glossop, Paul A., Hayes, Christopher J.

“…DMDO can be used to effect an oxidative partial deprotection of benzylidene acetals derived from both 1,2- and 1,3-diols to afford hydroxy benzoate ester…”
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