Search Results - "Sheridan, William P."

Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model by Julander, Justin G., Siddharthan, Venkatraman, Evans, Joe, Taylor, Ray, Tolbert, Kelsey, Apuli, Chad, Stewart, Jason, Collins, Preston, Gebre, Makda, Neilson, Skot, Van Wettere, Arnaud, Lee, Young-Min, Sheridan, William P., Morrey, John D., Babu, Y.S.

“…Zika virus (ZIKV) is currently undergoing pandemic emergence. While disease is typically subclinical, severe neurologic manifestations in fetuses and newborns…”
Get full text

BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease by Taylor, Raymond, Kotian, Pravin, Warren, Travis, Panchal, Rekha, Bavari, Sina, Julander, Justin, Dobo, Sylvia, Rose, Angela, El-Kattan, Yahya, Taubenheim, Brian, Babu, Yarlagadda, Sheridan, William P

“…Summary The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening…”
Get full text

Oral berotralstat for the prophylaxis of hereditary angioedema attacks in patients in Japan: A phase 3 randomized trial by Ohsawa, Isao, Honda, Daisuke, Suzuki, Yusuke, Fukuda, Tomoo, Kohga, Keisuke, Morita, Eishin, Moriwaki, Shinichi, Ishikawa, Osamu, Sasaki, Yoshihiro, Tago, Masaki, Chittick, Greg, Cornpropst, Melanie, Murray, Sharon C., Dobo, Sylvia M., Nagy, Eniko, Van Dyke, Sharon, Reese, Lacy, Best, Jessica M., Iocca, Heather, Collis, Phil, Sheridan, William P., Hide, Michihiro

“…Background With no approved treatments in Japan for the prevention of hereditary angioedema (HAE) attacks, there is a significant unmet need for long‐term…”
Get full text

BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model by Julander, Justin G, Bantia, Shanta, Taubenheim, Brian R, Minning, Dena M, Kotian, Pravin, Morrey, John D, Smee, Donald F, Sheridan, William P, Babu, Yarlagadda S

“…No effective antiviral therapies are currently available to treat disease after infection with yellow fever virus (YFV). A Syrian golden hamster model of…”
Get full text

Randomized Trial of the Efficacy and Safety of Berotralstat (BCX7353) as an Oral Prophylactic Therapy for Hereditary Angioedema: Results of APeX-2 Through 48 Weeks (Part 2) by Wedner, H. James, Aygören-Pürsün, Emel, Bernstein, Jonathan, Craig, Timothy, Gower, Richard, Jacobs, Joshua S., Johnston, Douglas T., Lumry, William R., Zuraw, Bruce L., Best, Jessica M., Iocca, Heather A., Murray, Sharon C., Desai, Bhavisha, Nagy, Eniko, Sheridan, William P., Kiani-Alikhan, Sorena

“…Berotralstat (BCX7353) is a recently approved, oral, once-daily kallikrein inhibitor for hereditary angioedema (HAE) prophylaxis. In the APeX-2 trial,…”
Get full text

Population pharmacokinetic modeling and simulations of berotralstat for prophylactic treatment of attacks of hereditary angioedema by Mathis, Amanda, Sale, Mark, Cornpropst, Melanie, Sheridan, William P., Ma, Shu Chin

“…Hereditary angioedema (HAE) is an autosomal dominant disorder characterized by recurrent episodes of swelling of the skin, larynx, gastrointestinal tract,…”
Get full text

Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat by Aygören-Pürsün, Emel, MD, Magerl, Markus, MD, Graff, Jochen, MD, Martinez-Saguer, Inmaculada, MD, Kreuz, Wolfhart, MD, Longhurst, Hilary, MD, PhD, Nasr, Iman, MD, Bas, Murat, MD, Straßen, Ulrich, MD, Fang, Lei, PhD, Cornpropst, Melanie, PhD, Dobo, Sylvia, MD, Collis, Phil, PhD, Sheridan, William P., MD, Maurer, Marcus, MD, PhD

“…For several decades, attenuated androgens were the only oral prophylaxis drugs widely used in HAE despite their androgenic and anabolic effects.8 Managing HAE…”
Get full text

Long‐term safety and effectiveness of berotralstat for hereditary angioedema: The open‐label APeX‐S study by Farkas, Henriette, Stobiecki, Marcin, Peter, Jonny, Kinaciyan, Tamar, Maurer, Marcus, Aygören‐Pürsün, Emel, Kiani‐Alikhan, Sorena, Wu, Adrian, Reshef, Avner, Bygum, Anette, Fain, Olivier, Hagin, David, Huissoon, Aarnoud, Jeseňák, Miloš, Lindsay, Karen, Panovska, Vesna Grivcheva, Steiner, Urs C., Zubrinich, Celia, Best, Jessica M., Cornpropst, Melanie, Dix, Daniel, Dobo, Sylvia M., Iocca, Heather A., Desai, Bhavisha, Murray, Sharon C., Nagy, Eniko, Sheridan, William P.

“…Background Berotralstat (BCX7353) is an oral, once‐daily inhibitor of plasma kallikrein recently approved for prevention of angioedema attacks in adults and…”
Get full text

Single dose peramivir for the treatment of acute seasonal influenza: integrated analysis of efficacy and safety from two placebo-controlled trials by Whitley, Richard, Laughlin, Alan, Carson, Simon, Mitha, Essack, Tellier, Guy, Stich, Mark, Elder, Jenna, Alexander, W James, Dobo, Sylvia, Collis, Phil, Sheridan, William P

“…Current influenza treatment options include oral or inhaled antiviral agents. There is an unmet need for parenteral antiviral treatments. Peramivir, a…”
Get more information

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 by Warren, Travis K., Wells, Jay, Panchal, Rekha G., Stuthman, Kelly S., Garza, Nicole L., Van Tongeren, Sean A., Dong, Lian, Retterer, Cary J., Eaton, Brett P., Pegoraro, Gianluca, Honnold, Shelley, Bantia, Shanta, Kotian, Pravin, Chen, Xilin, Taubenheim, Brian R., Welch, Lisa S., Minning, Dena M., Babu, Yarlagadda S., Sheridan, William P., Bavari, Sina

“…A broad-spectrum antiviral small molecule is reported to act as an inhibitor of viral polymerase activity and is shown to be effective in protecting non-human…”
Get full text

A direct-acting antiviral drug abrogates viremia in Zika virus-infected rhesus macaques by Lim, So-Yon, Osuna, Christa E, Best, Katharine, Taylor, Ray, Chen, Elsa, Yoon, Gyeol, Kublin, Jessica L, Schalk, Dane, Schultz-Darken, Nancy, Capuano, Saverio, Safronetz, David, Luo, Ma, MacLennan, Steve, Mathis, Amanda, Babu, Yarlagadda S, Sheridan, William P, Perelson, Alan S, Whitney, James B

“…Zika virus infection in humans has been associated with serious reproductive and neurological complications. At present, no protective antiviral drug treatment…”
Get more information

Evaluation of intravenous peramivir for treatment of influenza in hospitalized patients by de Jong, Menno D, Ison, Michael G, Monto, Arnold S, Metev, Hristo, Clark, Carol, O'Neil, Brian, Elder, Jenna, McCullough, Amy, Collis, Phil, Sheridan, William P

“…Seasonal influenza causes >200 000 annual hospitalizations in the United States. Current antiviral treatment options are limited to oral or inhaled agents…”
Get full text

Pharmacokinetics and Safety of the Nucleoside Analog Antiviral Drug Galidesivir Administered to Healthy Adult Subjects by Mathis, Amanda, Collins, David, Dobo, Sylvia, Walling, Dennis M., Sheridan, William P., Taylor, Ray

“…Galidesivir (BCX4430) is an adenosine nucleoside analog broadly active in cell culture against multiple RNA virus families, and active in animal models of…”
Get full text

Oral Plasma Kallikrein Inhibitor BCX7353 is Safe and Effective as an On-Demand Treatment of Angioedema Attacks in Hereditary Angioedema (HAE) Patients: Results of the ZENITH-1 Trial by Longhurst, Hilary, Moldovan, Dumitru, Bygum, Anette, Cicardi, Marco, Huissoon, Aarnoud, Aygoren-Pursun, Emel, Grivcheva-Panovska, Vesna, Hagin, David, Steiner, Urs, Stobiecki, Marcin, Aberer, Werner, Bethune, Claire, Faust, Saul N., Kiani, Sorena, Launay, David, Maurer, Marcus, Rae, William, Reshef, Avner, Cornpropst, Melanie T., Dobo, Sylvia M., VanDyke, Sharon, Murray, Sharon, Collis, Phillip J., Sheridan, William P., Farkas, Henriette

Get full text

Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters by Westover, Jonna B., Mathis, Amanda, Taylor, Ray, Wandersee, Luci, Bailey, Kevin W., Sefing, Eric J., Hickerson, Brady T., Jung, Kie-Hoon, Sheridan, William P., Gowen, Brian B.

“…Rift Valley fever virus (RVFV) is a mosquito-borne pathogen endemic to sub-Saharan Africa and the Arabian Peninsula. There are no approved antiviral therapies…”
Get full text

Intravenous peramivir for treatment of influenza in hospitalized patients by Ison, Michael G, Fraiz, Joseph, Heller, Barry, Jauregui, Luis, Mills, Graham, O'Riordan, William, O'Neil, Brian, Playford, E Geoffrey, Rolf, J Douglass, Sada-Diaz, Eduardo, Elder, Jenna, Collis, Phil, Hernandez, Jaime E, Sheridan, William P

“…Influenza causes over 200,000 hospitalizations a year in the United States, but few antiviral treatment studies have focused on patients hospitalized with…”
Get more information

Response to Several Recent Publications Related to Safety and Efficacy of Peramivir From the Emergency Use Authorization Experience by Ison, Michael G., Hollister, Alan S., Sheridan, William P.

Get full text

Development of GnRH Antagonists for Prostate Cancer: New Approaches to Treatment by Cook, Terry, Sheridan, William P.

“…Prostate cancer has become the most common cancer among American men and is second only to lung cancer as a cause of male cancer‐related death. Several…”
Get full text

Impact of the 2009/2010 influenza A (H1N1) pandemic on trends in influenza hospitalization, diagnostic testing, and treatment by Hernandez, Jaime E., Grainger, Joanne, Simonsen, Lone, Collis, Phil, Edelman, Laurel, Sheridan, William P.

“…Please cite this paper as: Hernandez et al. (2012) Impact of the 2009/2010 influenza A (H1N1) pandemic on trends in influenza hospitalization, diagnostic…”
Get full text

BCX9930, an Oral Factor D Inhibitor in Development for Treatment of Complement-Mediated Diseases, Inhibits Complement Alternative Pathway (AP) Activity in Healthy Subjects: PO1654 by Chen, Xilin, Zhu, Fugang, Parker, Cynthia D., Cornpropst, Melanie, Sheridan, William P., Davidson, Matthew, Babu, Yarlagadda S.

Get full text