Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells

The first example of synchrotron X‐ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first quantitative analysis of the incorporation of a bromine‐labelled cyclic RGD peptide and its effects on the biodistribution of endogenous element...

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Bibliographic Details
Published in:	Journal of synchrotron radiation Vol. 20; no. 2; pp. 226 - 233
Main Authors:	Sheridan, Erin J., Austin, Christopher J. D., Aitken, Jade B., Vogt, Stefan, Jolliffe, Katrina A., Harris, Hugh H., Rendina, Louis M.
Format:	Journal Article
Language:	English
Published:	5 Abbey Square, Chester, Cheshire CH1 2HU, England International Union of Crystallography 01-03-2013 John Wiley & Sons, Inc
Subjects:	Animals BASIC BIOLOGICAL SCIENCES Bromine CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS Fluorescence Humans Imaging Instruments & Instrumentation Lung Neoplasms - metabolism Melanoma, Experimental - metabolism Mice microprobe Neovascularization, Pathologic - prevention & control Oligopeptides - chemistry Oligopeptides - metabolism Optics OTHER INSTRUMENTATION Peptides Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacokinetics Physics Quantitative analysis Research Papers RGD peptide Spectrometry, X-Ray Emission - methods Synchrotron radiation Synchrotrons tumor cells Tumor Cells, Cultured Tumors X-rays XRF tumor cells XRF RGD peptide microprobe
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Summary:	The first example of synchrotron X‐ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first quantitative analysis of the incorporation of a bromine‐labelled cyclic RGD peptide and its effects on the biodistribution of endogenous elements (for example, K and Cl) within individual tumor cells.
Bibliography:	ark:/67375/WNG-FHX18MGW-T istex:C79375DBB5E0B9A6B17086A833BD3679045C47DA ArticleID:JSYHF5218 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 AC02-06CH11357 USDOE Office of Science (SC)
ISSN:	1600-5775 0909-0495 1600-5775
DOI:	10.1107/S0909049513001647