Search Results - "Sheppard, N. F."

Enzyme microgels in packed-bed bioreactors with downstream amperometric detection using microfabricated interdigitated microsensor electrode arrays by Guiseppi-Elie, Anthony, Sheppard Jr, Norman F., Brahim, Sean, Narinesingh, Dyer

“…In this article, we describe the use of pH‐ responsive hydrogels as matrices for the immobilization of two enzymes, glucose oxidase (GOx) and glutamate oxidase…”
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Magnitude and modulation of pancreatic beta-cell gap junction electrical conductance in situ by Mears, D, Sheppard, Jr, N F, Atwater, I, Rojas, E

“…The parallel gap junction electrical conductance between a beta-cell and its nearest neighbors was measured by using an intracellular microelectrode to clamp…”
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Evidence that calcium release-activated current mediates the biphasic electrical activity of mouse pancreatic beta-cells by Mears, D, Sheppard, Jr, N F, Atwater, I, Rojas, E, Bertram, R, Sherman, A

“…The electrical response of pancreatic beta-cells to step increases in glucose concentration is biphasic, consisting of a prolonged depolarization with action…”
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Microfabricated Centrifugal Microfluidic Systems:  Characterization and Multiple Enzymatic Assays by Duffy, David C, Gillis, Heather L, Lin, Joe, Sheppard, Norman F, Kellogg, Gregory J

“…This paper describes a microfluidic system in which fluids are pumped by centrifugal force through microscopic channels defined in a plastic disk in order to…”
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Functional Organization of Rat Olfactory Bulb Glomeruli Revealed by Optical Imaging by Keller, Asaf, Yagodin, Sergey, Aroniadou-Anderjaska, Vassiliki, Zimmer, Lee A, Ennis, Matthew, Sheppard, Norman F., Jr, Shipley, Michael T

“…The functional organization and synaptic physiology of olfactory bulb glomeruli were studied in rat in vitro slice preparations stained with the…”
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Mapping Membrane Potential Transients in Crayfish (Procambarus clarkii) Optic Lobe Neuropils With Voltage-Sensitive Dyes by Yagodin, Sergey, Collin, Carlos, Alkon, Daniel L, Sheppard, Norman F., Jr, Sattelle, David B

“…Sergey Yagodin 1 , 3 , Carlos Collin 2 , Daniel L. Alkon 2 , Norman F. Sheppard Jr. 1 , and David B. Sattelle 3 1  Department of Biomedical Engineering, Johns…”
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Electrical conductivity of pH-responsive hydrogels by Sheppard, Norman F., Lesho, Matthew J., Tucker, Robert C., Salehi-Had, Samira

“…The electrical conductivity of pH-responsive hydrogels based on cross-linked poly(2-hydroxyethyl methacrylate-co-dimethylaminoethyl methacrylate) copolymers…”
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Model of an immobilized enzyme conductimetric urea biosensor by Sheppard, Norman F., Mears, David J., Guiseppi-Elie, Anthony

“…A model for predicting the response of a conductimetric urea biosensor was developed and validated experimentally. The biosensor under consideration is formed…”
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Electrical conductivity measurements using microfabricated interdigitated electrodes by Sheppard, Norman F, Tucker, Robert C, Wu, Christine

“…A study constructed interdigitated electrode arrays to be used as miniature conductivity cells. Values resulting from conducted arrays agreed well with…”
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Adhesion of polymer films to oxidized silicon and its effect on performance of a conductometric pH sensor by Lesho, Matthew J, Sheppard, Norman F

“…The use of a silane coupling agent, γ-methacryloxypropyl trimethoxysilane (γ-MPS), to promote adhesion of photolithographically patterned polymer hydrogels to…”
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Microfabricated conductimetric pH sensor by Sheppard, Norman F., Lesho, Matthew J., McNally, Philip, Shaun Francomacaro, A.

“…A miniature conductimetric pH sensor has been developed, based on the measurement of the conductivity of a pH-responsive hydrogel. The microfabricated sensor…”
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Micromachined silicon structures for modelling polymer matrix controlled release systems by Sheppard, Norman F., Mears, David J., Straka, Scott W.

“…Physical models of polymer matrix controlled release systems were constructed by using silicon micromachining to fabricate miniature pore networks having…”
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First-in-human testing of a wirelessly controlled drug delivery microchip by Farra, Robert, Sheppard, Jr, Norman F, McCabe, Laura, Neer, Robert M, Anderson, James M, Santini, Jr, John T, Cima, Michael J, Langer, Robert

“…The first clinical trial of an implantable microchip-based drug delivery device is discussed. Human parathyroid hormone fragment (1-34) [hPTH(1-34)] was…”
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Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device by Santini, John T, Prescott, James H, Lipka, Sara, Baldwin, Samuel, Sheppard, Norman F, Maloney, John M, Coppeta, Jonathan, Yomtov, Barry, Staples, Mark A

“…Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled…”
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Electrothermally activated microchips for implantable drug delivery and biosensing by Maloney, John M., Uhland, Scott A., Polito, Benjamin F., Sheppard, Norman F., Pelta, Christina M., Santini, John T.

“…Novel drug delivery and biosensing devices have the potential to increase the efficacy of drug therapy by providing physicians and patients the ability to…”
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WP-B2 chemical reaction monitoring with the charge-flow transistor by Sheppard, N.F., Appelman, H.R., Poh, S.Y., Senturia, S.D.

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A method for studying swelling kinetics based on measurement of electrical conductivity by Lesho, Matthew J., Sheppard, Norman F.

“…A novel method was applied to the study of swelling kinetics of pH-responsive hydrogels. This technique is based on the pH-dependent electrical conductivity of…”
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The Second Report on the Teaching of Geometry by Siddons, A. W., Hope-Jones, W., Hooke, M. A., Beardwood, H., Kenworthy-Browne, Inman, S., Sheppard, N. F., Kearney, R. A. M., Snell, K. S., Roebuck, F. A., Broadbent, T. A. A., Fletcher, W. C.

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Extracellular electrode model applied to the pancreatic beta cell by Bierer, S.M., Sheppard, N.F.

“…A planar array of metal microelectrodes has been fabricated to measure the electrical activity of pancreatic beta cells. These cells secrete insulin and…”
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Model of a conductimetric urea sensor by Sheppard, N.F., Mears, D.J.

“…A model for predicting the response of a conductimetric urea sensor was developed. The sensor under consideration is formed by immobilizing the enzyme urease…”
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