Search Results - "Sheppard, Kelly Ann"

RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation by Zhang, Long, Huang, Huizhe, Zhou, FangFang, Schimmel, Joost, Pardo, Cristina Gontan, Zhang, Tingting, Barakat, Tahsin Stefan, Sheppard, Kelly-Ann, Mickanin, Craig, Porter, Jeff A., Vertegaal, Alfred C.O., van Dam, Hans, Gribnau, Joost, Lu, Chris X., ten Dijke, Peter

“…TGF-β members are of key importance during embryogenesis and tissue homeostasis. Smad7 is a potent antagonist of TGF-β family/Smad-mediated responses, but the…”
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Transcriptional Activation by NF-κB Requires Multiple Coactivators by Sheppard, Kelly-Ann, Rose, David W., Haque, Zaffar K., Kurokawa, Riki, McInerney, Eileen, Westin, Stefan, Thanos, Dimitris, Rosenfeld, Michael G., Glass, Christopher K., Collins, Tucker

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USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor by Zhang, Long, Zhou, FangFang, Drabsch, Yvette, Gao, Rui, Snaar-Jagalska, B. Ewa, Mickanin, Craig, Huang, Huizhe, Sheppard, Kelly-Ann, Porter, Jeff A., Lu, Chris X., ten Dijke, Peter

“…The stability and membrane localization of the transforming growth factor-β (TGF-β) type I receptor (TβRI) determines the levels of TGF-β signalling. TβRI is…”
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TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis by Zhang, Long, Zhou, Fangfang, García de Vinuesa, Amaya, de Kruijf, Esther M., Mesker, Wilma E., Hui, Li, Drabsch, Yvette, Li, Yihao, Bauer, Andreas, Rousseau, Adrien, Sheppard, Kelly-Ann, Mickanin, Craig, Kuppen, Peter J.K., Lu, Chris X., ten Dijke, Peter

“…TGF-β signaling is a therapeutic target in advanced cancers. We identified tumor necrosis factor receptor-associated factor 4 (TRAF4) as a key component…”
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Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling by Zhou, FangFang, Drabsch, Yvette, Dekker, Tim J. A., de Vinuesa, Amaya Garcia, Li, Yihao, Hawinkels, Lukas J. A. C., Sheppard, Kelly-Ann, Goumans, Marie-José, Luwor, Rodney B., de Vries, Carlie J., Mesker, Wilma E., Tollenaar, Rob A. E. M., Devilee, Peter, Lu, Chris X., Zhu, Hongjian, Zhang, Long, Dijke, Peter ten

“…In advanced cancers, the TGF-β pathway acts as an oncogenic factor and is considered to be a therapeutic target. Here using a genome-wide cDNA screen, we…”
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PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ by Sheppard, Kelly-Ann, Fitz, Lori J., Lee, Julie M., Benander, Christina, George, Judith A., Wooters, Joe, Qiu, Yongchang, Jussif, Jason M., Carter, Laura L., Wood, Clive R., Chaudhary, Divya

“…Engagement of the immunoinhibitory receptor, programmed death-1 (PD-1) attenuates T-cell receptor (TCR)-mediated activation of IL-2 production and T-cell…”
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Nuclear Integration of Glucocorticoid Receptor and Nuclear Factor-κB Signaling by CREB-binding Protein and Steroid Receptor Coactivator-1 by Sheppard, Kelly-Ann, Phelps, Kathleen M., Williams, Amy J., Thanos, Dimitris, Glass, Christopher K., Rosenfeld, Michael G., Gerritsen, Mary E., Collins, Tucker

“…The p65 (RelA) component of nuclear factor-κB (NF-κB) and the glucocorticoid receptor (GR) mutually repress each other's ability to activate transcription…”
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RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation by Zhang, Long, Huang, Huizhe, Zhou, FangFang, Schimmel, Joost, Pardo, Cristina Gontan, Zhang, Tingting, Barakat, Tahsin Stefan, Sheppard, Kelly-Ann, Mickanin, Craig, Porter, Jeff A., Vertegaal, Alfred C.O., van Dam, Hans, Gribnau, Joost, Lu, Chris X., ten Dijke, Peter

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The retinoblastoma protein region required for interaction with the E2F transcription factor includes the T/E1A binding and carboxy-terminal sequences by Huang, S, Shin, E, Sheppard, K A, Chokroverty, L, Shan, B, Qian, Y W, Lee, E Y, Yee, A S

“…Recent experiments in understanding the mechanism of the retinoblastoma protein (RB) function have revealed the existence of several cellular proteins that are…”
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An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy by Lach-Trifilieff, Estelle, Minetti, Giulia C., Sheppard, KellyAnn, Ibebunjo, Chikwendu, Feige, Jerome N., Hartmann, Steffen, Brachat, Sophie, Rivet, Helene, Koelbing, Claudia, Morvan, Frederic, Hatakeyama, Shinji, Glass, David J.

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Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth by Harbinski, Fred, Craig, Vanessa J, Sanghavi, Sneha, Jeffery, Douglas, Liu, Lijuan, Sheppard, Kelly Ann, Wagner, Sabrina, Stamm, Christelle, Buness, Andreas, Chatenay-Rivauday, Christian, Yao, Yao, He, Feng, Lu, Chris X, Guagnano, Vito, Metz, Thomas, Finan, Peter M, Hofmann, Francesco, Sellers, William R, Porter, Jeffrey A, Myer, Vic E, Graus-Porta, Diana, Wilson, Christopher J, Buckler, Alan, Tiedt, Ralph

“…The overall power of kinase inhibitors is substantially overshadowed by the acquisition of drug resistance. To address this issue, we systematically assessed…”
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Lipoxin generation by human megakaryocyte-induced 12-lipoxygenase by Sheppard, K A, Greenberg, S M, Funk, C D, Romano, M, Serhan, C N

“…Eicosanoid biosynthesis was examined with a human megakaryocytic cell line (Dami). Megakaryocytes incubated with [1-14C]arachidonic acid and either ionophore…”
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USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-[beta] type I receptor by Zhang, Long, Zhou, Fangfang, Drabsch, Yvette, Gao, Rui, Snaar-jagalska, B Ewa, Mickanin, Craig, Huang, Huizhe, Sheppard, Kelly-ann, Porter, Jeff A, Lu, Chris X, Ten Dijke, Peter

“…The stability and membrane localization of the transforming growth factor-[beta] (TGF-[beta]) type I receptor (T[beta]RI) determines the levels of TGF-[beta]…”
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Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation by Xu, M, Sheppard, K A, Peng, C Y, Yee, A S, Piwnica-Worms, H

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HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family by Tevosian, S G, Shih, H H, Mendelson, K G, Sheppard, K A, Paulson, K E, Yee, A S

“…A prominent feature of cell differentiation is the initiation and maintenance of an irreversible cell cycle arrest with the complex involvement of the…”
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Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-[beta] signalling by Zhou, Fangfang, Drabsch, Yvette, Dekker, Tim J A, De Vinuesa, Amaya Garcia, Li, Yihao, Hawinkels, Lukas J A C, Sheppard, Kelly-ann, Goumans, Marie-josé, Luwor, Rodney B, De Vries, Carlie J, Mesker, Wilma E, Tollenaar, Rob A E M, Devilee, Peter, Lu, Chris X, Zhu, Hongjian, Zhang, Long, Dijke, Peter Ten

“…In advanced cancers, the TGF-β pathway acts as an oncogenic factor and is considered to be a therapeutic target. Here using a genome-wide cDNA screen, we…”
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Lipoxin formation during human neutrophil-platelet interactions: evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro by SERHAN, C. N, SHEPPARD, K.-A

“…Human neutrophils from peripheral blood may physically interact with platelets in several settings including hemostasis, inflammation, and a variety of…”
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PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta by Sheppard, Kelly-Ann, Fitz, Lori J, Lee, Julie M, Benander, Christina, George, Judith A, Wooters, Joe, Qiu, Yongchang, Jussif, Jason M, Carter, Laura L, Wood, Clive R, Chaudhary, Divya

“…Engagement of the immunoinhibitory receptor, programmed death-1 (PD-1) attenuates T-cell receptor (TCR)-mediated activation of IL-2 production and T-cell…”
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PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3 direct sum signalosome and downstream signaling to PKC plus or minus by Sheppard, Kelly-Ann, Fitz, Lori J, Lee, Julie M, Benander, Christina, George, Judith A, Wooters, Joe, Qiu, Yongchang, Jussif, Jason M, Carter, Laura L, Wood, Clive R, Chaudhary, Divya

“…Engagement of the immunoinhibitory receptor, programmed death-1 (PD-1) attenuates T-cell receptor (TCR)-mediated activation of IL-2 production and T-cell…”
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Nuclear Integration of Glucocorticoid Receptor and Nuclear Factor-κB Signaling by CREB-binding Protein and Steroid Receptor Coactivator-1 by Kelly-Ann Sheppard, Kathleen M. Phelps, Amy J. Williams, Dimitris Thanos, Christopher K. Glass, Michael G. Rosenfeld, Mary E. Gerritsen, Tucker Collins

“…The p65 (RelA) component of nuclear factor-κB (NF-κB) and the glucocorticoid receptor (GR) mutually repress each other’s ability to activate transcription…”
Get full text