Search Results - "Sheppard, Freda C. D."

Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1 by Brown, Louisa M, Cowen, Rachel L, Debray, Camille, Eustace, Amanda, Erler, Janine T, Sheppard, Freda C D, Parker, Catriona A, Stratford, Ian J, Williams, Kaye J

“…The resistance of hypoxic cells to conventional chemotherapy is well documented. Using both adenovirus-mediated gene delivery and small molecules targeting…”
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Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: Reversing tumor radioresistance and effecting cure by COWEN, Rachel L, WILLIAMS, Kaye J, CHINJE, Edwin C, JAFFAR, Mohammed, SHEPPARD, Freda C. D, TELFER, Brian A, WIND, Natasha S, STRATFORD, Ian J

“…Solid tumors are characterized by regions of hypoxia that are inherently resistant to both radiotherapy and some chemotherapy. To target this resistant…”
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Hypoxia Targeted Gene Therapy to Increase the Efficacy of Tirapazamine as an Adjuvant to Radiotherapy by Cowen, Rachel L., Williams, Kaye J., Chinje, Edwin C., Jaffar, Mohammed, Sheppard, Freda C. D., Telfer, Brian A., Wind, Natasha S., Stratford, Ian J.

“…Abstract Solid tumors are characterized by regions of hypoxia that are inherently resistant to both radiotherapy and some chemotherapy. To target this…”
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Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumor cells by Chadderton, Naomi, Cowen, Rachel L, Sheppard, Freda C D, Robinson, Suzanne, Greco, Olga, Scott, Simon D, Stratford, Ian J, Patterson, Adam V, Williams, Kaye J

“…Tumor hypoxia is unequivocally linked to poor radiotherapy outcome. This study aimed to identify enhancer sequences that respond maximally to a combination of…”
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