Search Results - "Sheppard, Donald C."

Biofilm Exopolysaccharides of Pathogenic Fungi: Lessons from Bacteria by Sheppard, Donald C., Howell, P. Lynne

“…Exopolysaccharides play an important structural and functional role in the development and maintenance of microbial biofilms. Although the majority of research…”
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The role of mast cells in the defence against pathogens by Urb, Mirjam, Sheppard, Donald C

“…[...]over the course of hours, the transcriptional up-regulation of cytokines and chemokines, including TNF-α and interleukin-4, can be observed. Importantly,…”
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Tackling the emerging threat of antifungal resistance to human health by Fisher, Matthew C., Alastruey-Izquierdo, Ana, Berman, Judith, Bicanic, Tihana, Bignell, Elaine M., Bowyer, Paul, Bromley, Michael, Brüggemann, Roger, Garber, Gary, Cornely, Oliver A., Gurr, Sarah. J., Harrison, Thomas S., Kuijper, Ed, Rhodes, Johanna, Sheppard, Donald C., Warris, Adilia, White, P. Lewis, Xu, Jianping, Zwaan, Bas, Verweij, Paul E.

“…Invasive fungal infections pose an important threat to public health and are an under-recognized component of antimicrobial resistance, an emerging crisis…”
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Molecular mechanism of Aspergillus fumigatus adherence to host constituents by Sheppard, Donald C

“…Highlights ► Adherence to host constituents is a key early step in the pathogenesis of invasive aspergillosis. ► Early studies focused on the identification of…”
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Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture by Fisher, Matthew C, Gurr, Sarah J, Cuomo, Christina A, Blehert, David S, Jin, Hailing, Stukenbrock, Eva H, Stajich, Jason E, Kahmann, Regine, Boone, Charles, Denning, David W, Gow, Neil A R, Klein, Bruce S, Kronstad, James W, Sheppard, Donald C, Taylor, John W, Wright, Gerard D, Heitman, Joseph, Casadevall, Arturo, Cowen, Leah E

“…The fungal kingdom includes at least 6 million eukaryotic species and is remarkable with respect to its profound impact on global health, biodiversity,…”
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The Interface between Fungal Biofilms and Innate Immunity by Kernien, John F, Snarr, Brendan D, Sheppard, Donald C, Nett, Jeniel E

“…Fungal biofilms are communities of adherent cells surrounded by an extracellular matrix. These biofilms are commonly found during infection caused by a variety…”
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Deacetylated microbial biofilm exopolysaccharides: It pays to be positive by Ostapska, Hanna, Howell, P Lynne, Sheppard, Donald C

“…About the Authors: Hanna Ostapska Affiliations Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada, Infectious Diseases in…”
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Fungal invasion of normally non-phagocytic host cells by Filler, Scott G, Sheppard, Donald C

“…Many fungi that cause invasive disease invade host epithelial cells during mucosal and respiratory infection, and subsequently invade endothelial cells during…”
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The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps by Lee, Mark J, Liu, Hong, Barker, Bridget M, Snarr, Brendan D, Gravelat, Fabrice N, Al Abdallah, Qusai, Gavino, Christina, Baistrocchi, Shane R, Ostapska, Hanna, Xiao, Tianli, Ralph, Benjamin, Solis, Norma V, Lehoux, Mélanie, Baptista, Stefanie D, Thammahong, Arsa, Cerone, Robert P, Kaminskyj, Susan G W, Guiot, Marie-Christine, Latgé, Jean-Paul, Fontaine, Thierry, Vinh, Donald C, Filler, Scott G, Sheppard, Donald C

“…Of the over 250 Aspergillus species, Aspergillus fumigatus accounts for up to 80% of invasive human infections. A. fumigatus produces galactosaminogalactan…”
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International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus by Verweij, Paul E, Ananda-Rajah, Michelle, Andes, David, Arendrup, Maiken C, Brüggemann, Roger J, Chowdhary, Anuradha, Cornely, Oliver A, Denning, David W, Groll, Andreas H, Izumikawa, Koichi, Kullberg, Bart Jan, Lagrou, Katrien, Maertens, Johan, Meis, Jacques F, Newton, Pippa, Page, Iain, Seyedmousavi, Seyedmojtaba, Sheppard, Donald C, Viscoli, Claudio, Warris, Adilia, Donnelly, J. Peter

“…Abstract An international expert panel was convened to deliberate the management of azole-resistant aspergillosis. In culture-positive cases, in vitro…”
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Recent advances in the understanding of the Aspergillus fumigatus cell wall by Lee, Mark J, Sheppard, Donald C

“…Over the past several decades, research on the synthesis and organization of the cell wall polysaccharides of Aspergillus fumigatus has expanded our knowledge…”
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Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases by Le Mauff, François, Bamford, Natalie C., Alnabelseya, Noor, Zhang, Yongzhen, Baker, Perrin, Robinson, Howard, Codée, Jeroen D.C., Howell, P. Lynne, Sheppard, Donald C.

“…During infection, the fungal pathogen Aspergillus fumigatus forms biofilms that enhance its resistance to antimicrobials and host defenses. An integral…”
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PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms by Little, Dustin J, Pfoh, Roland, Le Mauff, François, Bamford, Natalie C, Notte, Christina, Baker, Perrin, Guragain, Manita, Robinson, Howard, Pier, Gerald B, Nitz, Mark, Deora, Rajendar, Sheppard, Donald C, Howell, P Lynne

“…Poly-β(1,6)-N-acetyl-D-glucosamine (PNAG) is a major biofilm component of many pathogenic bacteria. The production, modification, and export of PNAG in…”
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Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis by Speth, Cornelia, Rambach, Günter, Lass-Flörl, Cornelia, Howell, P. Lynne, Sheppard, Donald C.

“…Aspergillus spp and particularly the species Aspergillus fumigatus are the causative agents of invasive aspergillosis, a progressive necrotizing pneumonia that…”
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Posaconazole-Loaded Leukocytes as a Novel Treatment Strategy Targeting Invasive Pulmonary Aspergillosis by Baistrocchi, Shane R., Lee, Mark J., Lehoux, Melanie, Ralph, Benjamin, Snarr, Brendan D., Robitaille, Robert, C. Sheppard, Donald

“…Background. Impaired delivery of antifungals to hyphae within necrotic lesions is thought to contribute to therapeutic failure in invasive pulmonary…”
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Understanding Aspergillus fumigatus galactosaminogalactan biosynthesis: A few questions remain by Le Mauff, François, Sheppard, Donald C.

“…Half a century after their discovery, polymers of N-acetylgalactosamine produced by the Aspergilli have garnered new interest as mediators of fungal virulence…”
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Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation by Bamford, Natalie C., Le Mauff, François, Van Loon, Jaime C., Ostapska, Hanna, Snarr, Brendan D., Zhang, Yongzhen, Kitova, Elena N., Klassen, John S., Codée, Jeroen D. C., Sheppard, Donald C., Howell, P. Lynne

“…The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus . Deletion of a gene encoding a…”
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Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal β-glucan from the immune system by Gravelat, Fabrice N, Beauvais, Anne, Liu, Hong, Lee, Mark J, Snarr, Brendan D, Chen, Dan, Xu, Wenjie, Kravtsov, Ilia, Hoareau, Christopher M Q, Vanier, Ghyslaine, Urb, Mirjam, Campoli, Paolo, Al Abdallah, Qusai, Lehoux, Melanie, Chabot, Josée C, Ouimet, Marie-Claude, Baptista, Stefanie D, Fritz, Jörg H, Nierman, William C, Latgé, Jean Paul, Mitchell, Aaron P, Filler, Scott G, Fontaine, Thierry, Sheppard, Donald C

“…Aspergillus fumigatus is the most common cause of invasive mold disease in humans. The mechanisms underlying the adherence of this mold to host cells and…”
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Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection by Snarr, Brendan D, St-Pierre, Guillaume, Ralph, Benjamin, Lehoux, Mélanie, Sato, Yukiko, Rancourt, Ann, Takazono, Takahiro, Baistrocchi, Shane R, Corsini, Rachel, Cheng, Matthew P, Sugrue, Michele, Baden, Lindsey R, Izumikawa, Koichi, Mukae, Hiroshi, Wingard, John R, King, Irah L, Divangahi, Maziar, Satoh, Masahiko S, Yipp, Bryan G, Sato, Sachiko, Sheppard, Donald C

“…Aspergillus fumigatus is an opportunistic mold that infects patients who are immunocompromised or have chronic lung disease, causing significant morbidity and…”
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Impaired RASGRF1/ERK–mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians by Gavino, Christina, MSc, Hamel, Nancy, MSc, Zeng, Ji Bin, PhD, Legault, Catherine, MD, Guiot, Marie-Christine, MD, PhD, Chankowsky, Jeffrey, MD, Lejtenyi, Duncan, MSc, Lemire, Martine, MD, Alarie, Isabelle, MD, Dufresne, Simon, MD, Boursiquot, Jean-Nicolas, MD, McIntosh, Fiona, MSc, Langelier, Mélanie, BScN, Behr, Marcel A., MD, Sheppard, Donald C., MD, Foulkes, William D., MBBS, PhD, Vinh, Donald C., MD

“…Background Caspase recruitment domain-containing protein 9 (CARD9) deficiency is an autosomal recessive primary immunodeficiency conferring human…”
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