Search Results - "Sheppard, Catherine L."

Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression by Sheppard, Catherine L., Lee, Louisa C.Y., Hill, Elaine V., Henderson, David J.P., Anthony, Diana F., Houslay, Daniel M., Yalla, Krishna C., Cairns, Lynne S., Dunlop, Allan J., Baillie, George S., Huston, Elaine, Houslay, Miles D.

“…In Rat-1 cells, the dramatic decrease in the levels of both intracellular cyclic 3′5′ adenosine monophosphate (cyclic AMP; cAMP) and in the activity of…”
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Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579 by Hill, Elaine V., Sheppard, Catherine L., Cheung, York-Fong, Gall, Irene, Krause, Eberhard, Houslay, Miles D.

“…RAW macrophages, which express the PDE4D3 and PDE4D5 cAMP phosphodiesterase isoforms, exhibited increased PDE4 activity when challenged with H 2O 2 in a…”
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