Mammarenaviruses of Rodents, South Africa and Zimbabwe

Mammarenaviruses of Rodents, South Africa and Zimbabwe

We conducted a survey for group-specific indirect immunofluorescence antibody to mammarenaviruses by using Lassa fever and Mopeia virus antigens on serum specimens of 5,363 rodents of 33 species collected in South Africa and Zimbabwe during 1964-1994. Rodents were collected for unrelated purposes or...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 27; no. 12; pp. 3092 - 3102
Main Authors: Grobbelaar, Antoinette A, Jardine, Jocelyn, Burt, Felicity J, Shepherd, Alasdair J, Shepherd, Susan P, Leman, Patricia A, Kemp, Alan, Braack, Lawrence E O, Weyer, Jacqueline, Paweska, Janusz T, Swanepoel, Robert
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01-12-2021
Centers for Disease Control and Prevention
Subjects:
Animals
Antigens
Arenaviridae
Arenavirus diseases
Arenaviruses
Causes of
Cytochrome
Disease Reservoirs
Diseases
Ebola virus
Fever
Genetic aspects
Identification and classification
Infectious diseases
Lassa virus
mammarenavirus
Mammarenaviruses of Rodents, South Africa and Zimbabwe
Mastomys natalensis
Medical laboratories
Monoclonal antibodies
Mopeia virus
Murinae
Phylogenetics
Phylogeny
Polls & surveys
Risk factors
Rodents
South Africa
South Africa - epidemiology
Statistics
Surveillance
Viruses
Zimbabwe
Zimbabwe - epidemiology
South Africa
Zimbabwe
Mozambique
United States > US
Africa
Mopeia virus
viruses
Natal multimammate mouse
mammarenavirus
South Africa
Zimbabwe
Mastomys natalensis
rodents
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Description
Summary:We conducted a survey for group-specific indirect immunofluorescence antibody to mammarenaviruses by using Lassa fever and Mopeia virus antigens on serum specimens of 5,363 rodents of 33 species collected in South Africa and Zimbabwe during 1964-1994. Rodents were collected for unrelated purposes or for this study and stored at -70°C. We found antibody to be widely distributed in the 2 countries; antibody was detected in serum specimens of 1.2%-31.8% of 14 species of myomorph rodents, whereas 19 mammarenavirus isolates were obtained from serum specimens and viscera of 4 seropositive species. Phylogenetic analysis on the basis of partial nucleoprotein sequences indicates that 14 isolates from Mastomys natalensis, the Natal multimammate mouse, were Mopeia virus, whereas Merino Walk virus was characterized as a novel virus in a separate study. The remaining 4 isolates from 3 rodent species potentially constitute novel viruses pending full characterization.
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ISSN:1080-6040
1080-6059
DOI:10.3201/eid2712.211088