Search Results - "Shepherd, Ruth M."

Hyperinsulinism in Infancy: From Basic Science to Clinical Disease by DUNNE, MARK J, COSGROVE, KAREN E, SHEPHERD, RUTH M, AYNSLEY-GREEN, ALBERT, LINDLEY, KEITH J

“…The School of Biological Sciences, University of Manchester, Manchester; and Institute of Child Health, Great Ormond Street Hospital, London, United Kingdom…”
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Glucose-Dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator by JOHNSON, Daniel, SHEPHERD, Ruth M, GILL, Debra, GORMAN, Tracy, SMITH, David M, DUNNE, Mark J

“…Glucose-Dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator Daniel Johnson 1 , Ruth M. Shepherd 1 ,…”
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PAX4 enhances beta-cell differentiation of human embryonic stem cells by Liew, Chee Gee, Shah, Nadia N, Briston, Sarah J, Shepherd, Ruth M, Khoo, Cheen Peen, Dunne, Mark J, Moore, Harry D, Cosgrove, Karen E, Andrews, Peter W

“…Human embryonic stem cells (HESC) readily differentiate into an apparently haphazard array of cell types, corresponding to all three germ layers, when their…”
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A recessive contiguous gene deletion causing infantile hyperinsulinism, enteropathy and deafness identifies the Usher type 1C gene by Bitner-Glindzicz, Maria, Glaser, Benjamin, Lindley, Keith J, Rutland, Paul, Blaydon, Diana, Smith, Virpi V, Milla, Peter J, Hussain, Khalid, Furth-Lavi, Judith, Cosgrove, Karen E, Shepherd, Ruth M, Barnes, Philippa D, O'Brien, Rachel E, Farndon, Peter A, Sowden, Jane, Liu, Xue-Zhong, Scanlan, Matthew J, Malcolm, Sue, Dunne, Mark J, Aynsley-Green, Albert

“…Usher syndrome type 1 describes the association of profound, congenital sensorineural deafness, vestibular hypofunction and childhood onset retinitis…”
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Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy and Mutations in the Sulfonylurea Receptor by Dunne, Mark J, Kane, Charlotte, Shepherd, Ruth M, Sanchez, Jorge A, James, Roger F.L, Johnson, Paul R.V, Aynsley-Green, Albert, Lu, Shan, Clement, John P, Lindley, Keith J, Seino, Susumu, Aguilar-Bryan, Lydia, Gonzalez, Gabriela, Milla, Peter J

“…Persistent hyperinsulinemic hypoglycemia of infancy is caused by inappropriate and excessive secretion of insulin. Although the disease is rare in outbred…”
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Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca(2+) by Macfarlane, Wendy M, Shepherd, Ruth M, Cosgrove, Karen E, James, Roger FL

“…Glucose regulates insulin production in pancreatic beta-cells in the long term by stimulating insulin gene transcription. These effects are partially mediated…”
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Hyperinsulinism of infancy : The regulated release of insulin by KATP channel-independent pathways by STRAUB, Susanne G, COSGROVE, Karen E, LINDLEY, Keith J, SHARP, Geoffrey W. G, AYNSLEY-GREEN, Albert, DUNNE, Mark J, ÄMMÄLÄ, Carina, SHEPHERD, Ruth M, O'BRIEN, Rachel E, BARNES, Philippa D, KUCHINSKI, Na'Ama, CHAPMAN, Joanna C, SCHAEPPI, Michela, GLASER, Benjamin

“…Hyperinsulinism of infancy (HI) is a congenital defect in the regulated release of insulin from pancreatic beta-cells. Here we describe stimulus-secretion…”
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The Role of Metabolism, Cytoplasmic Ca, and pH-regulating Exchangers in Glucose-induced Rise of Cytoplasmic pH in Normal Mouse Pancreatic Islets by Ruth M. Shepherd, Jean-Claude Henquin

“…Intact mouse islets were loaded with 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein to study the effects of glucose on cytoplasmic pH (pH ) in…”
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Engineering a Glucose-responsive Human Insulin-secreting Cell Line from Islets of Langerhans Isolated from a Patient with Persistent Hyperinsulinemic Hypoglycemia of Infancy by MacFarlane, W M, Chapman, J C, Shepherd, R M, Hashmi, M N, Kamimura, N, Cosgrove, K E, O'Brien, R E, Barnes, P D, Hart, A W, Docherty, H M, Lindley, K J, Aynsley-Green, A, James, R F, Docherty, K, Dunne, M J

“…Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is a neonatal disease characterized by dysregulation of insulin secretion accompanied by profound…”
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Genetics and pathophysiology of hyperinsulinism in infancy by Cosgrove, Karen E, Shepherd, Ruth M, Fernandez, Eva M, Natarajan, Anuja, Lindley, Keith J, Aynsley-Green, Albert, Dunne, Mark J

“…Hyperinsulinism in infancy (HI) is a condition of neonates and early childhood. For many years the pathophysiology of this potentially lethal disorder was…”
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Hyperinsulinism of infancy: towards an understanding of unregulated insulin release by Shepherd, Ruth M, Cosgrove, Karen E, O'Brien, Rachel E, Barnes, Philippa D, Ämmälä, Carina, Dunne, Mark J

“…Insulin is synthesised, stored, and secreted from pancreatic β cells. These are located within the islets of Langerhans, which are distributed throughout the…”
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The Role of Metabolism, Cytoplasmic Ca2+, and pH-regulating Exchangers in Glucose-induced Rise of Cytoplasmic pH in Normal Mouse Pancreatic Islets (∗) by Shepherd, Ruth M., Henquin, Jean-Claude

“…Intact mouse islets were loaded with 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein to study the effects of glucose on cytoplasmic pH (pHi) in pancreatic…”
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Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y by Macfarlane, W M, O'Brien, R E, Barnes, P D, Shepherd, R M, Cosgrove, K E, Lindley, K J, Aynsley-Green, A, James, R F, Docherty, K, Dunne, M J

“…Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y. W M Macfarlane , R E O'Brien , P D Barnes , R M Shepherd ,…”
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Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: implications for stimulus‐response coupling of insulin release by Shepherd, Ruth M., Hashmi, Molly N., Kane, Charlotte, Squires, Paul E., Dunne, Mark J.

“…1 Microfluorimetry techniques with fura‐2 were used to characterize the effects of efaroxan (200 μm), phentolamine (200–500 μm) and idazoxan (200–500 μm) on…”
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Potassium Channels, Sulphonylurea Receptors and Control of Insulin Release by Dunne, Mark J, Cosgrove, Karen E, Shepherd, Ruth M, Ämmälä, Carina

“…Clinical profiles of the glucose regulation disorders persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI) and diabetes mellitus are diametrically…”
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Loss of functional K ATP channels in pancreatic β-cells causes persistent hyperinsulinemic hypoglycemia of infancy by Kane, Charlotte, Shepherd, Ruth M, Squires, Paul E, Johnson, Paul R.V, James, Roger F.L, Milla, Peter J, Aynsley-Green, Albert, Lindley, Keith J, Dunne, Mark J

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Causes and therapy of hyperinsulinism in infancy by Cosgrove, Karen E, Shepherd, Ruth M, Fernandez, Eva M, Natarajan, Anuja, Dunne, Mark J

“…ABSTRACTHyperinsulinism in infancy is a potentially lethal condition of neonates and occurs during early childhood as well. From defects in ion channel subunit…”
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Hyperinsulinism of infancy: The regulated release of insulin by K(ATP) channel-independent pathways by Straub, Susanne G, Cosbrove, Karen E, Ammala, Carina, Shepherd, Ruth M

“…Hyperinsulinism of infancy (HI) is a congenital defect in the regulated release of insulin from pancreatic beta-cells. Here we describe stimulus-secretion…”
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ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line by CHAPMAN, J. C, MCCLENAGHAN, N. H, COSGROVE, K. E, HASHMI, M. N, SHEPHERD, R. M, GIESBERTS, A. N, WHITE, S. J, ÄMMÄLÄ, C, FLATT, P. R, DUNNE, M. J

“…ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line. J C Chapman , N H McClenaghan , K…”
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Glucose Modulation of Insulin mRNA Levels Is Dependent on Transcription Factor PDX-1 and Occurs Independently of Changes in Intracellular [Ca.sup.2+] by Macfarlane, Wendy M, Shepherd, Ruth M, Cosgrove, Karen E, James, Roger F.L, Dunne, Mark J, Docherty, Kevin

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