Search Results - "Shepherd, L. E."

Topoisomerase II Alpha and Responsiveness of Breast Cancer to Adjuvant Chemotherapy by O’Malley, F. P., Chia, S., Tu, D., Shepherd, L. E., Levine, M. N., Bramwell, V. H., Andrulis, I. L., Pritchard, K. I.

“…Background Amplification or deletion of the topoisomerase II alpha (TOP2A) gene in breast cancers has been postulated to be more closely associated with…”
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Impact of premenopausal status at breast cancer diagnosis in women entered on the placebo-controlled NCIC CTG MA17 trial of extended adjuvant letrozole by Goss, P.E., Ingle, J.N., Martino, S., Robert, N.J., Muss, H.B., Livingston, R.B., Davidson, N.E., Perez, E.A., Chavarri-Guerra, Y., Cameron, D.A., Pritchard, K.I., Whelan, T., Shepherd, L.E., Tu, D.

“…MA17 showed improved outcomes in postmenopausal women given extended letrozole (LET) after completing 5 years of adjuvant tamoxifen. Exploratory subgroup…”
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An individual patient-data comparison of combined modality therapy and ABVD alone for patients with limited-stage Hodgkin lymphoma by Hay, A.E., Klimm, B., Chen, B.E., Goergen, H., Shepherd, L.E., Fuchs, M., Gospodarowicz, M.K., Borchmann, P., Connors, J.M., Markova, J., Crump, M., Lohri, A., Winter, J.N., Dörken, B., Pearcey, R.G., Diehl, V., Horning, S.J., Eich, H.T., Engert, A., Meyer, R.M.

“…Treatment options for patients with nonbulky stage IA–IIA Hodgkin lymphoma include combined modality therapy (CMT) using doxorubicin, bleomycin, vinblastine…”
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Topoisomerase II alpha protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA.5 adjuvant trial by O’Malley, F. P., Chia, S., Tu, D., Shepherd, L. E., Levine, M. N., Huntsman, D., Bramwell, V. H., Andrulis, I. L., Pritchard, K. I.

“…Overexpression of topoisomerase II protein (topo 2α) is postulated to be more closely associated with responsiveness to anthracycline-containing chemotherapy…”
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Outcomes in women with invasive ductal or invasive lobular early stage breast cancer treated with anastrozole or exemestane in CCTG (NCIC CTG) MA.27 by Strasser-Weippl, K., Sudan, G., Ramjeesingh, R., Shepherd, L.E., O'Shaughnessy, J., Parulekar, W.R., Liedke, P.E.R., Chen, B.E., Goss, P.E.

“…Histological subtype, (invasive ductal breast cancer (IDBC)/invasive lobular breast cancer (ILBC)), might be a marker for differential response to endocrine…”
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Do alternative methods of measuring tumor size, including consideration of multicentric/multifocal disease, enhance prognostic information beyond TNM staging in women with early stage breast cancer: an analysis of the NCIC CTG MA.5 and MA.12 clinical trials by Hilton, J. F., Bouganim, N., Dong, B., Chapman, J. W., Arnaout, A., O’Malley, F., Gelmon, K. A., Yerushalmi, R., Levine, M. N., Bramwell, V. H. C., Whelan, T. J., Pritchard, K. I., Shepherd, L. E., Clemons, M.

“…The AJCC staging criteria consider tumor size to be the largest dimension of largest tumor. Some case series suggest using summation of all tumor dimensions in…”
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Intent-to-treat analysis of the placebo-controlled trial of letrozole for extended adjuvant therapy in early breast cancer: NCIC CTG MA.17 by Ingle, J. N., Tu, D., Pater, J. L., Muss, H. B., Martino, S., Robert, N. J., Piccart, M. J., Castiglione, M., Shepherd, L. E., Pritchard, K. I., Livingston, R. B., Davidson, N. E., Norton, L., Perez, E. A., Abrams, J. S., Cameron, D. A., Palmer, M. J., Goss, P. E.

“…Background: MA.17 evaluated letrozole or placebo after 5 years of tamoxifen and showed significant improvement in disease-free survival (DFS) for letrozole…”
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Clinical outcomes of ethnic minority women in MA.17: a trial of letrozole after 5 years of tamoxifen in postmenopausal women with early stage breast cancer by Moy, B, Tu, D, Pater, JL, Ingle, JN, Shepherd, LE, Whelan, TJ, Goss, PE

“…Background: Aromatase inhibitors are widely employed in the adjuvant treatment of early stage breast cancer. The impact of aromatase inhibitors has not been…”
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Patterns of disease progression and outcomes in a randomized trial testing ABVD alone for patients with limited-stage Hodgkin lymphoma by Macdonald, D. A., Ding, K., Gospodarowicz, M. K., Wells, W. A., Pearcey, R. G., Connors, J. M., Winter, J. N., Horning, S. J., Djurfeldt, M. S., Shepherd, L. E., Meyer, R. M.

“…Background: In the National Cancer Institute of Canada Clinical Trials Group/Eastern Cooperative Oncology Group HD.6 trial, progression-free survival was…”
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Anthracycline-induced cardiotoxicity in patients with early-stage breast cancer: the Canadian Cancer Trials Group (CCTG) MA.21 experience by Dent, S. F., Botros, J., Rushton, M., Aseyev, O., Levine, M. N., Parulekar, W. R., O’Brien, P., Burnell, M., Pritchard, K. I., Chen, B. E., Shepherd, L. E.

“…Purpose Anthracyclines are frequently used in adjuvant treatment for early-stage breast cancer (ESBC). The purpose of this study was to evaluate cardiotoxic…”
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Impact of baseline BMI and weight change in CCTG adjuvant breast cancer trials by Yerushalmi, R., Dong, B., Chapman, J.W., Goss, P.E., Pollak, M.N., Burnell, M.J., Levine, M.N., Bramwell, V.H.C., Pritchard, K.I., Whelan, T.J., Ingle, J.N., Shepherd, L.E., Parulekar, W.R., Han, L., Ding, K., Gelmon, K.A.

“…We hypothesized that increased baseline BMI and BMI change would negatively impact clinical outcomes with adjuvant breast cancer systemic therapy. Data from…”
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Treatment outcomes for older patients with relapsed/refractory aggressive lymphoma receiving salvage chemotherapy and autologous stem cell transplantation are similar to younger patients: a subgroup analysis from the phase III CCTG LY.12 trial by Davison, K., Chen, B.E., Kukreti, V., Couban, S., Benger, A., Berinstein, N.L., Kaizer, L., Desjardins, P., Mangel, J., Zhu, L., Djurfeldt, M.S., Hay, A.E., Shepherd, L.E., Crump, M.

“…High-dose therapy and autologous stem cell transplantation (ASCT) is often considered for older patients (age >60 years) with relapsed/refractory aggressive…”
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The Role of Ankle Arthroscopy on the Surgical Management of Ankle Fractures by Thordarson, David B., Bains, Ravinder, Shepherd, Lane E.

“…Nineteen patients were prospectively randomized for operative treatment of their ankle fracture to be supplemented with or without ankle arthroscopy. All…”
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TLE3 is not a predictive biomarker for taxane sensitivity in the NCIC CTG MA.21 clinical trial by Bartlett, J M S, Nielsen, T O, Gao, D, Gelmon, K A, Quintayo, M A, Starczynski, J, Han, L, Burnell, M J, Levine, M N, Chen, B E, Shepherd, L E, Chapman, J W

“…Background: TLE3, a nuclear transcriptional repressor downstream of WNT signalling pathways, has been hypothesised as predictive of benefit from adjuvant…”
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A Pooled Analysis of Adjuvant Chemotherapy for Resected Colon Cancer in Elderly Patients by Sargent, Daniel J, Goldberg, Richard M, Jacobson, Stacy D, Macdonald, John S, Labianca, Roberto, Haller, Daniel G, Shepherd, Lois E, Seitz, Jean François, Francini, Guido

“…After successful surgery for colorectal cancer, patients over 70 years of age are less likely to receive postoperative (adjuvant) chemotherapy than younger…”
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Unusual Retention of Rhodamine 123 by Mitochondria in Muscle and Carcinoma Cells by Summerhayes, Ian C., Lampidis, Theodore J., Bernal, Samuel D., Nadakavukaren, John J., Nadakavukaren, Karen K., Shepherd, Elizabeth L., Chen, Lan Bo

“…Mitochondria in cardiac muscle cells and myoblast-fused myotubes display unusually long (3-5 days) retention times of rhodamine 123, a mitochondria-specific…”
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Capnocytophaga canimorsus, a potential emerging microorganism in splenectomized patients by Yu, Richard K., Shepherd, Lois E., Rapson, Dileys A.

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Escalated as Compared with Standard Doses of Doxorubicin in BACOP Therapy for Patients with Non-Hodgkin's Lymphoma by Meyer, Ralph M, Quirt, Ian C, Skillings, Jamey R, Cripps, M.C, Bramwell, Vivien, Weinerman, Brian H, Gospodarowicz, Mary K, Burns, Bruce F, Sargeant, Ann Marie, Shepherd, Lois E, Zee, Benny, Hryniuk, William M

“…In treating patients with cancer, the dose intensity of chemotherapeutic drugs, defined as the dose of drug per unit of time, may be a determinant of their…”
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Bioabsorbable Versus Stainless Steel Screw Fixation of the Syndesmosis in Pronation-Lateral Rotation Ankle Fractures: A Prospective Randomized Trial by Thordarson, David B., Samuelson, Michael, Shepherd, Lane E., Merkle, Paul F., Lee, Jackson

“…Thirty-two patients who had pronation-lateral rotation (PLR) fractures occurring four centimeters or more proximal to the ankle joint or lower if the talus was…”
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Inhibitory effects of the quinolone antibiotics trovafloxacin, ciprofloxacin, and levofloxacin on osteoblastic cells in vitro by Holtom, P D, Pavkovic, S A, Bravos, P D, Patzakis, M J, Shepherd, L E, Frenkel, B

“…We studied the inhibitory effects of the fluoroquinolones levofloxacin, ciprofloxacin, and trovafloxacin on growth and extracellular matrix mineralization in…”
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