Search Results - "Shepherd, Gordon M. G."

Untangling the cortico-thalamo-cortical loop: cellular pieces of a knotty circuit puzzle by Shepherd, Gordon M. G., Yamawaki, Naoki

“…Functions of the neocortex depend on its bidirectional communication with the thalamus, via cortico-thalamo-cortical (CTC) loops. Recent work dissecting the…”
Get full text

Long-range inhibitory intersection of a retrosplenial thalamocortical circuit by apical tuft-targeting CA1 neurons by Yamawaki, Naoki, Li, Xiaojian, Lambot, Laurie, Ren, Lynn Y., Radulovic, Jelena, Shepherd, Gordon M. G.

“…Hippocampus, granular retrosplenial cortex (RSCg), and anterior thalamic nuclei (ATN) interact to mediate diverse cognitive functions. To identify cellular…”
Get full text

Organization of cortical and thalamic input to pyramidal neurons in mouse motor cortex by Hooks, Bryan M, Mao, Tianyi, Gutnisky, Diego A, Yamawaki, Naoki, Svoboda, Karel, Shepherd, Gordon M G

“…Determining how long-range synaptic inputs engage pyramidal neurons in primary motor cortex (M1) is important for understanding circuit mechanisms involved in…”
Get full text

Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas by Hooks, B M, Hires, S Andrew, Zhang, Ying-Xin, Huber, Daniel, Petreanu, Leopoldo, Svoboda, Karel, Shepherd, Gordon M G

“…Rodents move their whiskers to locate and identify objects. Cortical areas involved in vibrissal somatosensation and sensorimotor integration include the…”
Get full text

Circuit and Plasticity Defects in the Developing Somatosensory Cortex of Fmr1 Knock-Out Mice by Bureau, Ingrid, Shepherd, Gordon M. G, Svoboda, Karel

“…Silencing of the Fmr1 gene causes fragile X syndrome. Although defects in synaptic plasticity in the cerebral cortex have been linked to cognitive impairments…”
Get full text

The neocortical circuit: themes and variations by Harris, Kenneth D, Shepherd, Gordon M G

“…Harris and Shepherd review our knowledge of input and output patterns for different classes of cortical cells. They propose that cortex, like other parts of…”
Get full text

An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice by Srivastava, Deepak P, Woolfrey, Kevin M, Jones, Kelly A, Anderson, Charles T, Smith, Katharine R, Russell, Theron A, Lee, Hyerin, Yasvoina, Marina V, Wokosin, David L, Ozdinler, P Hande, Shepherd, Gordon M G, Penzes, Peter

“…The architecture of dendritic arbors determines circuit connectivity, receptive fields, and computational properties of neurons, and dendritic structure is…”
Get full text

Corticostriatal connectivity and its role in disease by Shepherd, Gordon M. G.

“…Key Points Corticostriatal (CStr) projections are formed by two distinct classes of cortical pyramidal neurons: intratelencephalic (IT) and pyramidal tract…”
Get full text

Synaptic Circuit Abnormalities of Motor-Frontal Layer 2/3 Pyramidal Neurons in an RNA Interference Model of Methyl-CpG-Binding Protein 2 Deficiency by Wood, Lydia, Gray, Noah W, Zhou, Zhaolan, Greenberg, Michael E, Shepherd, Gordon M. G

“…Rett syndrome, an autism spectrum disorder with prominent motor and cognitive features, results from mutations in the gene for methyl-CpG-binding protein 2…”
Get full text

Laminarly orthogonal excitation of fast-spiking and low-threshold-spiking interneurons in mouse motor cortex by Apicella, Alfonso J, Wickersham, Ian R, Seung, H Sebastian, Shepherd, Gordon M G

“…In motor cortex, long-range output to subcortical motor circuits depends on excitatory and inhibitory inputs converging on projection neurons in layers 5A/B…”
Get full text

Laminar and Columnar Organization of Ascending Excitatory Projections to Layer 2/3 Pyramidal Neurons in Rat Barrel Cortex by Shepherd, Gordon M. G, Svoboda, Karel

“…Excitatory synaptic projections to layer 2/3 (L2/3) pyramidal neurons in brain slices from the rat barrel cortex were measured using quantitative…”
Get full text

Diversity and complexity in the pyramidal tract projectome by Shepherd, Gordon M. G.

Get full text

Hierarchical connectivity and connection-specific dynamics in the corticospinal-corticostriatal microcircuit in mouse motor cortex by Kiritani, Taro, Wickersham, Ian R, Seung, H Sebastian, Shepherd, Gordon M G

“…The generation of purposive movement by mammals involves coordinated activity in the corticospinal and corticostriatal systems, which are involved in different…”
Get full text

Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex by Anderson, Charles T, Shepherd, Gordon M G, Kiritani, Taro, Sheets, Patrick L

“…Local circuit connectivity patterns have been described as being either layer specific or projection class specific. Here, Anderson et al . find that the main…”
Get full text

Anterolateral Motor Cortex Connects with a Medial Subdivision of Ventromedial Thalamus through Cell Type-Specific Circuits, Forming an Excitatory Thalamo-Cortico-Thalamic Loop via Layer 1 Apical Tuft Dendrites of Layer 5B Pyramidal Tract Type Neurons by Guo, KuangHua, Yamawaki, Naoki, Svoboda, Karel, Shepherd, Gordon M G

“…The anterolateral motor cortex (ALM) and ventral medial (VM) thalamus are functionally linked to support persistent activity during motor planning. We analyzed…”
Get full text

A Corticocortical Circuit Directly Links Retrosplenial Cortex to M2 in the Mouse by Yamawaki, Naoki, Radulovic, Jelena, Shepherd, Gordon M G

“…Retrosplenial cortex (RSC) is a dorsomedial parietal area involved in a range of cognitive functions, including episodic memory, navigation, and spatial…”
Get full text

Mice with behavioral evidence of tinnitus exhibit dorsal cochlear nucleus hyperactivity because of decreased GABAergic inhibition by Middleton, Jason W, Kiritani, Taro, Pedersen, Courtney, Turner, Jeremy G, Shepherd, Gordon M.G, Tzounopoulos, Thanos

“…Tinnitus has been associated with increased spontaneous and evoked activity, increased neural synchrony, and reorganization of tonotopic maps of auditory…”
Get full text

GABAergic mechanisms regulated by miR-33 encode state-dependent fear by Jovasevic, Vladimir, Corcoran, Kevin A, Leaderbrand, Katherine, Yamawaki, Naoki, Guedea, Anita L, Chen, Helen J, Shepherd, Gordon M G, Radulovic, Jelena

“…Some stress-related memories are state-dependent: they cannot be retrieved unless the brain is in the same state as during initial encoding. The authors show…”
Get full text

Convergent cortical innervation of striatal projection neurons by Kress, Geraldine J, Yamawaki, Naoki, Wokosin, David L, Wickersham, Ian R, Shepherd, Gordon M G, Surmeier, D James

“…Prior anatomical studies have suggested that intratelencephalic (IT) and pyramidal tract (PT) cortical neurons project to different populations of striatal…”
Get full text

Top-down laminar organization of the excitatory network in motor cortex by Wood, Lydia, Weiler, Nicholas, Yu, Jianing, Shepherd, Gordon M G, Solla, Sara A

“…Cortical layering is a hallmark of the mammalian neocortex and a major determinant of local synaptic circuit organization in sensory systems. In motor cortex,…”
Get full text