Search Results - "Shepelev, Mikhail"

Increasing Gene Editing Efficiency via CRISPR/Cas9- or Cas12a-Mediated Knock-In in Primary Human T Cells by Kruglova, Natalia, Shepelev, Mikhail

“…T lymphocytes represent a promising target for genome editing. They are primarily modified to recognize and kill tumor cells or to withstand HIV infection. In…”
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Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41 by Maslennikova, Alexandra, Kruglova, Natalia, Kalinichenko, Svetlana, Komkov, Dmitriy, Shepelev, Mikhail, Golubev, Dmitriy, Siniavin, Andrei, Vzorov, Andrei, Filatov, Alexander, Mazurov, Dmitriy

“…Previous studies suggest that short peptides from the heptad repeat 2 (HR2) domain of gp41 expressed on the cell surface are more potent inhibitors of HIV-1…”
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A New Chimeric Antibody against the HIV-1 Fusion Inhibitory Peptide MT-C34 with a High Affinity and Fc-Mediated Cellular Cytotoxicity by Kalinichenko, Svetlana V, Ramadan, Lama, Kruglova, Natalia A, Balagurov, Konstantin I, Lukashina, Marina I, Mazurov, Dmitriy V, Shepelev, Mikhail V

“…Peptides from heptad repeat (HR1 and HR2) regions of gp41 are effective inhibitors of HIV-1 entry that block the fusion of viral and cellular membranes, but…”
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The genetics of Pak by Hofmann, Clemens, Shepelev, Mikhail, Chernoff, Jonathan

“…p21-activated kinases (Paks) are a highly conserved family of enzymes that bind to and are activated by small GTPases of the Cdc42 and Rac families. With the…”
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The RHOV gene is overexpressed in human non–small cell lung cancer by Shepelev, Mikhail V, Korobko, Igor V

“…Rho family GTPases act as molecular switches to regulate numerous cellular processes, including malignant transformation. Commonly, overexpression of Rho…”
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A gel-less isolation of untagged plasmid DNA insert from vector backbone in homogeneous format by Kalinichenko, Svetlana V., Shepelev, Mikhail V., Korobko, Igor V.

“…Agarose gel electrophoresis with subsequent DNA extraction from gel is routinely used for DNA fragment isolation after plasmid DNA digestion. We describe a…”
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Production of hornless dairy cattle from genome-edited blastocysts by Deykin, Alexey V., Bruter, Alexandra V., Krivonogova, Anna S., Shepelev, Mikhail V., Koshchaev, Andrey G.

“…Cattle of polled phenotype is convenient for breeders, as it decreases the risk of animals being hurt and ensures safety of workers. We developed the system…”
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hTERT and BIRC5 gene promoters for cancer gene therapy: A comparative study by Shepelev, Mikhail V, Kopantzev, Eugene P, Vinogradova, Tatiana V, Sverdlov, Eugene D, Korobko, Igor V

“…Human telomerase reverse transcriptase (hTERT) and survivin (BIRC5) gene promoters are frequently used for transcriptional targeting of tumor cells, yet there…”
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LY294002 Enhances Expression of Proteins Encoded by Recombinant Replication-Defective Adenoviruses via mTOR- and Non-mTOR-Dependent Mechanisms by Shepelev, Mikhail V, Korobko, Elena V, Vinogradova, Tatiana V, Kopantsev, Eugene P, Korobko, Igor V

“…Adenovirus-based drugs are efficient when combined with other anticancer treatments. Here we show that treatment with LY294002 and LY303511 upregulates…”
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Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation by Shepelev, Mikhail V., Chernoff, Jonathan, Korobko, Igor V.

“…Rho GTPases regulate numerous cellular processes including apoptosis. Chp/RhoV is an atypical Rho GTPase which functions are poorly understood. Here we…”
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Factors That Affect the Formation of Chromosomal Translocations in Cells by Canoy, Reynand Jay, Shmakova, Anna, Karpukhina, Anna, Shepelev, Mikhail, Germini, Diego, Vassetzky, Yegor

“…Chromosomal translocations are products of the illegitimate repair of DNA double-strand breaks (DSBs). Their formation can bring about significant structural…”
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