Search Results - "Shepard, Stacey"

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms by Quintás-Cardama, Alfonso, Vaddi, Kris, Liu, Phillip, Manshouri, Taghi, Li, Jun, Scherle, Peggy A, Caulder, Eian, Wen, Xiaoming, Li, Yanlong, Waeltz, Paul, Rupar, Mark, Burn, Timothy, Lo, Yvonne, Kelley, Jennifer, Covington, Maryanne, Shepard, Stacey, Rodgers, James D, Haley, Patrick, Kantarjian, Hagop, Fridman, Jordan S, Verstovsek, Srdan

“…Constitutive JAK2 activation in hematopoietic cells by the JAK2V617F mutation recapitulates myeloproliferative neoplasm (MPN) phenotypes in mice, establishing…”
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Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050 by Fridman, Jordan S, Scherle, Peggy A, Collins, Robert, Burn, Timothy C, Li, Yanlong, Li, Jun, Covington, Maryanne B, Thomas, Beth, Collier, Paul, Favata, Margaret F, Wen, Xiaoming, Shi, Jack, McGee, Ryan, Haley, Patrick J, Shepard, Stacey, Rodgers, James D, Yeleswaram, Swamy, Hollis, Greg, Newton, Robert C, Metcalf, Brian, Friedman, Steven M, Vaddi, Kris

“…Inhibiting signal transduction induced by inflammatory cytokines offers a new approach for the treatment of autoimmune diseases such as rheumatoid arthritis…”
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Enantioselective Synthesis of Janus Kinase Inhibitor INCB018424 via an Organocatalytic Aza-Michael Reaction by Lin, Qiyan, Meloni, David, Pan, Yongchun, Xia, Michael, Rodgers, James, Shepard, Stacey, Li, Mei, Galya, Laurine, Metcalf, Brian, Yue, Tai-Yuen, Liu, Pingli, Zhou, Jiacheng

“…An enantioselective synthesis of INCB018424 via organocatalytic asymmetric aza-Michael addition of pyrazoles (16 or 20) to (E)-3-cyclopentylacrylaldehyde (23)…”
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Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation by Fridman, Jordan S., Scherle, Peggy A., Collins, Robert, Burn, Timothy, Neilan, Claire L., Hertel, Denise, Contel, Nancy, Haley, Patrick, Thomas, Beth, Shi, Jack, Collier, Paul, Rodgers, James D., Shepard, Stacey, Metcalf, Brian, Hollis, Gregory, Newton, Robert C., Yeleswaram, Swamy, Friedman, Steven M., Vaddi, Kris

“…JAKs are required for signaling initiated by several cytokines (e.g., IL-4, IL-12, IL-23, thymic stromal lymphopoietin (TSLP), and IFNγ) implicated in the…”
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Metabolism, Excretion, and Pharmacokinetics of [14C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans by SHILLING, Adam D, NEDZA, Frank M, SHEPARD, Stacey, RODGERS, James, YUE, Tai-Yuen, YELESWARAM, Swamy, EMM, Thomas, DIAMOND, Sharon, MCKEEVER, Edward, PUNWANI, Naresh, WILLIAMS, William, ARVANITIS, Argyrios, GALYA, Laurine G, MEI LI

“…The metabolism, excretion, and pharmacokinetics of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile (INCB018424), a potent,…”
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Developing a JAK Inhibitor for Targeted Local Delivery: Ruxolitinib Cream by Smith, Paul, Yao, Wenqing, Shepard, Stacey, Covington, Maryanne, Lee, Jim, Lofland, Jennifer, Naim, Ahmad, Sheth, Trupti, Parikh, Bhavnish, Yeleswaram, Swamy

“…Named after the two-faced Roman god of doorways, Janus kinases (JAKs) represent a class of tyrosine kinases. The JAK signaling pathway is pivotal for the…”
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Metathesis Approach to the Synthesis of Polyheterocyclic Structures from Oxanorbornenes by Winkler, Jeffrey D, Asselin, Sylvie M, Shepard, Stacey, Yuan, Jing

“…The synthesis of stereochemically defined tri- and penta-heterocyclic ring systems 9 and 28, respectively, via the metathesis reaction of substituted…”
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1. Studies directed toward the total synthesis of aphidicolin. 2. A ring-metathesis cascade approach to novel rigid scaffolds derived from beta-amino acids by Shepard, Stacey

“…This dissertation describes two independent research projects. The first section describes studies directed toward the total synthesis of aphidicolin,…”
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ON THE FRONT LINES OF FRAUD: Workshops to show how to beat back scams by Shepard, Stacey

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ADVOCATING FOR OLDER ARIZONANS: Social Security, caregiving top priorities by Shepard, Stacey

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FIGHTING TO CURB ELDER ABUSE by Shepard, Stacey

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'AGE-FRIENDLY' GAINS MOMENTUM by Shepard, Stacey

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LEARN TO SPOT, AVOID SCAMMERS by Shepard, Stacey

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STEP ON A CRACK, AND THEN FIX IT by Shepard, Stacey

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IN STATEHOUSE, FINDING A VOICE by Shepard, Stacey

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HELPING OHIOANS TO AGE IN PLACE: Grants boost services for older residents by Shepard, Stacey

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FOR SAFE STREETS, TAKE A WALK by Shepard, Stacey

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HOUSING, CARE TOP 2024 AGENDA by Shepard, Stacey

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