Search Results - "Shepard, Ryan D."

Histone deacetylase inhibition reduces ventral tegmental area dopamine neuronal hyperexcitability involving AKAP150 signaling following maternal deprivation in juvenile male rats by Shepard, Ryan D., Langlois, Ludovic D., Authement, Michael E., Nugent, Fereshteh S.

“…Traumatic early life stress (ELS) is linked to dopamine (DA) dysregulation which increases the probability of developing psychiatric disorders in adolescence…”
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Targeting Endocannabinoid Signaling in the Lateral Habenula as an Intervention to Prevent Mental Illnesses Following Early Life Stress: A Perspective by Shepard, Ryan D, Nugent, Fereshteh S

“…Adverse events and childhood trauma increase the susceptibility towards developing psychiatric disorders (substance use disorder, anxiety, depression, etc.) in…”
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Early Life Stress- and Drug-Induced Histone Modifications Within the Ventral Tegmental Area by Shepard, Ryan D., Nugent, Fereshteh S.

“…Psychiatric illnesses are a major public health concern due to their prevalence and heterogeneity of symptom presentation resulting from a lack of efficacious…”
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Ketamine Reverses Lateral Habenula Neuronal Dysfunction and Behavioral Immobility in the Forced Swim Test Following Maternal Deprivation in Late Adolescent Rats by Shepard, Ryan D, Langlois, Ludovic D, Browne, Caroline A, Berenji, Aylar, Lucki, Irwin, Nugent, Fereshteh S

“…Mounting evidence suggests that the long-term effects of adverse early life stressors on vulnerability to drug addiction and mood disorders are related to…”
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Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula by Simmons, Sarah C., Shepard, Ryan D., Gouty, Shawn, Langlois, Ludovic D., Flerlage, William J., Cox, Brian M., Nugent, Fereshteh S.

“…The lateral habenula (LHb) is an epithalamic brain region associated with value-based decision making and stress evasion through its modulation of dopamine…”
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Regulation of GABA A Rs by Transmembrane Accessory Proteins by Han, Wenyan, Shepard, Ryan D, Lu, Wei

“…The vast majority of fast inhibitory transmission in the brain is mediated by GABA acting on GABA receptors (GABA Rs), which provides inhibitory balance to…”
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Regulation of GABAARs by Transmembrane Accessory Proteins by Han, Wenyan, Shepard, Ryan D., Lu, Wei

“…The vast majority of fast inhibitory transmission in the brain is mediated by GABA acting on GABAA receptors (GABAARs), which provides inhibitory balance to…”
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AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula by Simmons, Sarah C., Flerlage, William J., Langlois, Ludovic D., Shepard, Ryan D., Bouslog, Christopher, Thomas, Emily H., Gouty, Kaitlyn M., Sanderson, Jennifer L., Gouty, Shawn, Cox, Brian M., Dell’Acqua, Mark L., Nugent, Fereshteh S.

“…The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and…”
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Targeting histone deacetylation for recovery of maternal deprivation-induced changes in BDNF and AKAP150 expression in the VTA by Shepard, Ryan D., Gouty, Shawn, Kassis, Haifa, Berenji, Aylar, Zhu, William, Cox, Brian M., Nugent, Fereshteh S.

“…Severe early life stressors increase the probability of developing psychiatric disorders later in life through modifications in neuronal circuits controlling…”
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Morphine-induced synaptic plasticity in the VTA is reversed by HDAC inhibition by Authement, Michael E, Langlois, Ludovic D, Kassis, Haifa, Gouty, Shawn, Dacher, Matthieu, Shepard, Ryan D, Cox, Brian M, Nugent, Fereshteh S

“…Dopamine (DA) dysfunction originating from the ventral tegmental area (VTA) occurs as a result of synaptic abnormalities following consumption of drugs of…”
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Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self‐administration in rats by Langlois, Ludovic D., Berman, Rina Y., Shepard, Ryan D., Simmons, Sarah C., Tsuda, Mumeko C., Gouty, Shawn, Choi, Kwang H., Nugent, Fereshteh S.

“…Early life stress presents an important risk factor for drug addiction and comorbid depression and anxiety through persistent effects on the mesolimbic…”
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