Search Results - "Shepard, H.Michael"

Mutations in the Catalytic Domain of Human Matrix Metalloproteinase-1 (MMP-1) That Allow for Regulated Activity through the Use of Ca2 by Paladini, Rudolph D., Wei, Ge, Kundu, Anirban, Zhao, Qiping, Bookbinder, Louis H., Keller, Gilbert A., Shepard, H.Michael, Frost, Gregory I.

“…Conditionally active proteins regulated by a physiological parameter represent a potential new class of protein therapeutics. By systematically creating point…”
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Abstract 442: Treatment of tumor xenografts in vivo with PEGylated human recombinant hyaluronidase PH20 (PEGPH20) does not increase the metastatic behavior of malignant cells by Li, Xiaoming, Jiang, Ping, Symons, Rebecca, Kadhim, Salam, Wei, Ge, Zhao, Qiping, Frost, Gregory I., Shepard, H.Michael, Thompson, Curtis B.

“…Hyaluronan (HA), a nonsulfated glycosaminoglycan, is a significant component of the extracellular matrix of many solid tumors. HA accumulation has been…”
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Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase by Lackey, David B., Groziak, Michael P., Sergeeva, Maria, Beryt, Malgorzata, Boyer, Christopher, Stroud, Robert M., Sayre, Peter, Park, John W., Johnston, Patrick, Slamon, Dennis, Shepard, H.Michael, Pegram, Mark

“…The in vivo administration of enzyme-inhibiting drugs for cancer and infectious disease often results in overexpression of the targeted enzyme. We have…”
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Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase11Abbreviations: BVdU, (E)-5-(2-bromovinyl)-2′-deoxyuridine; BVdUMP, (E)-5-(2-bromovinyl)-2′-deoxyuridine 5′-monophosphate; NB1011, (E)-5-(2-bromovinyl)-2′-deoxy-5′-uridyl phenyl l-methoxyalaninylphosphoramidate; COSY, correlated spectroscopy; DCI, direct current ionization; DMF, N,N-dimethylformamide; dUMP, 2′-deoxyuridine 5′-monophosphate; ECTA, enzyme-catalyzed therapeutic by Lackey, David B., Groziak, Michael P., Sergeeva, Maria, Beryt, Malgorzata, Boyer, Christopher, Stroud, Robert M., Sayre, Peter, Park, John W., Johnston, Patrick, Slamon, Dennis, Shepard, H.Michael, Pegram, Mark

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Retinoblastoma protein monoclonal antibodies with novel characteristics by Wen, S F, Nodelman, M, Nared-Hood, K, Duncan, J, Geradts, J, Shepard, H M

“…We have developed a family of monoclonal antibodies directed against the retinoblastoma gene product (p110RB). One of these monoclonal antibodies, 3C8, binds…”
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Synthesis of human fibroblast interferon by E. coli by Goeddel, David V., Shepard, H.Michael, Elizabeth, Yelverton, Leung, David, Crea, Roberto, Sloma, Alan, Pestka, Sidney

“…A cDNA library was constructed using mRNA from human fibroblasts induced with poly(I):poly(C). A bacterial clone containing fibroblast interferon cDNA…”
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A single base-pair alteration is responsible for the DNA overproduction phenotype of a plasmid copy-number mutant by Muesing, M, Tamm, J, Shepard, H M, Polisky, B

“…The Cop- plasmid pOP1 delta 6 is a recessive copy-number mutant derived from Col E1.pOP1 delta 6 exists at 200-300 copies per chromosome in E. coli, while Col…”
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