Search Results - "Shepard, H. Michael"

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer by Whatcott, Clifford J, Diep, Caroline H, Jiang, Ping, Watanabe, Aprill, LoBello, Janine, Sima, Chao, Hostetter, Galen, Shepard, H Michael, Von Hoff, Daniel D, Han, Haiyong

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by high levels of fibrosis, termed desmoplasia, which is thought to hamper the efficacy of…”
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Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase by DuFort, Christopher C., DelGiorno, Kathleen E., Carlson, Markus A., Osgood, Ryan J., Zhao, Chunmei, Huang, Zhongdong, Thompson, Curtis B., Connor, Robert J., Thanos, Christopher D., Scott Brockenbrough, J., Provenzano, Paolo P., Frost, Gregory I., Michael Shepard, H., Hingorani, Sunil R.

“…Elevated interstitial fluid pressure can present a substantial barrier to drug delivery in solid tumors. This is particularly true of pancreatic ductal…”
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Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression by Li, Xiaoming, Shepard, H Michael, Cowell, Jessica A, Zhao, Chunmei, Osgood, Ryan J, Rosengren, Sanna, Blouw, Barbara, Garrovillo, Sheryl A, Pagel, Mark D, Whatcott, Clifford J, Han, Haiyong, Von Hoff, Daniel D, Taverna, Darin M, LaBarre, Michael J, Maneval, Daniel C, Thompson, Curtis B

“…The tumor microenvironment (TME) evolves to support tumor progression. One marker of more aggressive malignancy is hyaluronan (HA) accumulation. Here, we…”
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Breaching the Castle Walls: Hyaluronan Depletion as a Therapeutic Approach to Cancer Therapy by Shepard, H Michael

“…Hyaluronan (HA) has many functions in the extracellular milieu of normal and diseased tissues. Disease-associated HA accumulation has been shown to predict a…”
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Tumor-associated hyaluronan limits efficacy of monoclonal antibody therapy by Singha, Netai C, Nekoroski, Tara, Zhao, Chunmei, Symons, Rebecca, Jiang, Ping, Frost, Gregory I, Huang, Zhongdong, Shepard, H Michael

“…Despite tremendous progress in cancer immunotherapy for solid tumors, clinical success of monoclonal antibody (mAb) therapy is often limited by poorly…”
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Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors by Wang, Lin, Londono, Luz M, Cowell, Jessica, Saatci, Ozge, Aras, Mertkaya, Ersan, Pelin G, Serra, Sara, Pei, Hong, Clift, Renee, Zhao, Qiping, Phan, Kim B, Huang, Lei, LaBarre, Michael J, Li, Xiaoming, Shepard, H Michael, Deaglio, Silvia, Linden, Joel, Thanos, Christopher D, Sahin, Ozgur, Cekic, Caglar

“…Extracellular adenosine in tumors can suppress immune responses and promote tumor growth. Adenosine deaminase 2 (ADA2) converts adenosine into inosine. The…”
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Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models by Thompson, Curtis B, Shepard, H Michael, O'Connor, Patrick M, Kadhim, Salam, Jiang, Ping, Osgood, Ryan J, Bookbinder, Louis H, Li, Xiaoming, Sugarman, Barry J, Connor, Robert J, Nadjsombati, Sinisa, Frost, Gregory I

“…Hyaluronan (HA) is a glycosaminoglycan polymer that often accumulates in malignancy. Megadalton complexes of HA with proteoglycans create a hydrated connective…”
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Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family by Shepard, H Michael, Brdlik, Cathleen M, Schreiber, Hans

“…The human EGFR (HER) family is essential for communication between many epithelial cancer cell types and the tumor microenvironment. Therapeutics targeting the…”
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Therapeutic targeting of hyaluronan in the tumor stroma by Kultti, Anne, Li, Xiaoming, Jiang, Ping, Thompson, Curtis B, Frost, Gregory I, Shepard, H Michael

“…The tumor stroma, consisting of non-malignant cells and the extracellular matrix, undergoes significant quantitative and qualitative changes throughout…”
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Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment by Singha, Netai C., Zhao, Chunmei, Kultti, Anne, Zimmerman, Susan, Osgood, Ryan J., Symons, Rebecca, Jiang, Ping, Li, Xiaoming, Thompson, Curtis B., Infante, Jeffrey R., Jacobetz, Michael A., Tuveson, David A., Frost, Gregory I., Shepard, H. Michael, Huang, Zhongdong

“…Extensive accumulation of the glycosaminoglycan hyaluronan is found in pancreatic cancer. The role of hyaluronan synthases 2 and 3 (HAS2, 3) was investigated…”
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Trastuzumab: dreams, desperation and hope by Shepard, H. Michael

“…The story of trastuzumab begins with Axel Ullrich’s dedication to the concept that receptor tyrosine kinases must be the key to many human diseases. It…”
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KIAA1199 expression and hyaluronan degradation colocalize in multiple sclerosis lesions by Marella, Mathieu, Jadin, Laurence, Keller, Gilbert A, Sugarman, Barry J, Frost, Gregory I, Shepard, H Michael

“…Abstract Modification of hyaluronan (HA) accumulation has been shown to play a key role in regulating inflammatory processes linked to the progression of…”
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Characterization of a Novel Recombinant Hyaluronan Binding Protein for Tissue Hyaluronan Detection by Jadin, Laurence, Huang, Lei, Wei, Ge, Zhao, Qiping, Gelb, Arnold B., Frost, Gregory I., Jiang, Ping, Shepard, H. Michael

“…Tumor necrosis factor-Stimulated Gene 6 protein (TSG-6) is a hyaluronan (HA)-binding glycoprotein containing an HA-binding Link module. Because of its…”
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Response to Chauhan et al.: Interstitial Pressure and Vascular Collapse in Pancreas Cancer—Fluids and Solids, Measurement and Meaning by DelGiorno, Kathleen E., Carlson, Markus A., Osgood, Ryan, Provenzano, Paolo P., Brockenbough, J. Scott, Thompson, Curtis B., Shepard, H. Michael, Frost, Gregory I., Potter, John D., Hingorani, Sunil R.

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Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell by He, Yanran, Schreiber, Karin, Wolf, Steven P, Wen, Frank, Steentoft, Catharina, Zerweck, Jonathan, Steiner, Madeline, Sharma, Preeti, Shepard, H Michael, Posey, Avery, June, Carl H, Mandel, Ulla, Clausen, Henrik, Leisegang, Matthias, Meredith, Stephen C, Kranz, David M, Schreiber, Hans

“…Human cancer cells were eradicated by adoptive transfer of T cells transduced with a chimeric antigen receptor (CAR) made from an antibody (237Ab) that is…”
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Biomarker-Driven Drug Discovery in Cancer—Trastuzumab Development: 2019 Lasker-DeBakey Clinical Medical Research Award by Shepard, H. Michael

“…In this Viewpoint, 2019 Lasker-DeBakey Clinical Medical Research Award winner H. Michael Shepard discusses development of trastuzumab, the first fully…”
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The Team that Just Wouldn’t Quit and a New Paradigm in Cancer Drug Discovery by Shepard, H. Michael

“…Receiving the Lasker award for Clinical Medical Research is a staggering event. Perhaps equally staggering is the fact that as many as 2 million women…”
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Developments in therapy with monoclonal antibodies and related proteins by Shepard, H Michael, Phillips, Gail Lewis, Thanos, Christopher D, Feldmann, Marc

“…Monoclonal antibody therapeutics have been approved for over 30 targets and diseases, most commonly cancer. Antibodies have become the new backbone of the…”
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Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer by Hingorani, Sunil R, Harris, William P, Beck, J Thaddeus, Berdov, Boris A, Wagner, Stephanie A, Pshevlotsky, Eduard M, Tjulandin, Sergei A, Gladkov, Oleg A, Holcombe, Randall F, Korn, Ronald, Raghunand, Natarajan, Dychter, Samuel, Jiang, Ping, Shepard, H Michael, Devoe, Craig E

“…This phase Ib study evaluated the safety and tolerability of PEGylated human recombinant hyaluronidase (PEGPH20) in combination with gemcitabine (Gem), and…”
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Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade by Gompels, Luke L, Malik, Nasser M, Madden, Leigh, Jin, Pei, Feldmann, Marc, Shepard, H Michael, Paleolog, Ewa M

“…Rheumatoid arthritis (RA) is a chronic disease associated with inflammation and destruction of bone and cartilage. Although inhibition of TNFα is widely used…”
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