Search Results - "Shepard, Eric M."

Insights into [FeFe]-Hydrogenase Structure, Mechanism, and Maturation by Mulder, David W., Shepard, Eric M., Meuser, Jonathan E., Joshi, Neelambari, King, Paul W., Posewitz, Matthew C., Broderick, Joan B., Peters, John W.

“…Hydrogenases are metalloenzymes that are key to energy metabolism in a variety of microbial communities. Divided into three classes based on their metal…”
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Decarboxylation involving a ferryl, propionate, and a tyrosyl group in a radical relay yields heme b by Streit, Bennett R., Celis, Arianna I., Moraski, Garrett C., Shisler, Krista A., Shepard, Eric M., Rodgers, Kenton R., Lukat-Rodgers, Gudrun S., DuBois, Jennifer L.

“…The H2O2-dependent oxidative decarboxylation of coproheme III is the final step in the biosynthesis of heme b in many microbes. However, the coproheme…”
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[FeFe]-Hydrogenase Cyanide Ligands Derived From S-Adenosylmethionine-Dependent Cleavage of Tyrosine by Driesener, Rebecca C, Challand, Martin R, McGlynn, Shawn E, Shepard, Eric M, Boyd, Eric S, Broderick, Joan B, Peters, John W, Roach, Peter L

“…What's your poison? Hydrogenases catalyze the reversible formation of dihydrogen from two electrons and two protons. The maturation of the [FeFe]‐hydrogenase…”
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Biosynthesis of complex iron–sulfur enzymes by Shepard, Eric M, Boyd, Eric S, Broderick, Joan B, Peters, John W

“…Recent advances in our understanding of the mechanisms for the biosynthesis of the complex iron–sulfur (Fe–S) containing prosthetic groups associated with…”
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Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold by Shepard, Eric M, McGlynn, Shawn E, Bueling, Alexandra L, Grady-Smith, Celestine S, George, Simon J, Winslow, Mark A, Cramer, Stephen P, Peters, John W, Broderick, Joan B

“…The organometallic H cluster at the active site of [FeFe]-hydrogenase consists of a 2Fe subcluster coordinated by cyanide, carbon monoxide, and a nonprotein…”
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Characterization of the Preprocessed Copper Site Equilibrium in Amine Oxidase and Assignment of the Reactive Copper Site in Topaquinone Biogenesis by Adelson, Charles N, Johnston, Esther M, Hilmer, Kimberly M, Watts, Hope, Dey, Somdatta Ghosh, Brown, Doreen E, Broderick, Joan B, Shepard, Eric M, Dooley, David M, Solomon, Edward I

“…Copper-dependent amine oxidases produce their redox active cofactor, 2,4,5-trihydroxyphenylalanine quinone (TPQ), via the CuII-catalyzed oxygenation of an…”
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EPR and FTIR Analysis of the Mechanism of H2 Activation by [FeFe]-Hydrogenase HydA1 from Chlamydomonas reinhardtii by Mulder, David W, Ratzloff, Michael W, Shepard, Eric M, Byer, Amanda S, Noone, Seth M, Peters, John W, Broderick, Joan B, King, Paul W

“…While a general model of H2 activation has been proposed for [FeFe]-hydrogenases, the structural and biophysical properties of the intermediates of the…”
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A shift between mineral and nonmineral sources of iron and sulfur causes proteome-wide changes in Methanosarcina barkeri by Fausset, Hunter, Spietz, Rachel L, Cox, Savannah, Cooper, Gwendolyn, Spurzem, Scott, Tokmina-Lukaszewska, Monika, DuBois, Jennifer, Broderick, Joan B, Shepard, Eric M, Boyd, Eric S, Bothner, Brian

“…Iron (Fe) and sulfur (S) are required elements for life, and changes in their availability can limit the ecological distribution and function of…”
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Structure and Inhibition of Human Diamine Oxidase by McGrath, Aaron P, Hilmer, Kimberly M, Collyer, Charles A, Shepard, Eric M, Elmore, Bradley O, Brown, Doreen E, Dooley, David M, Guss, J. Mitchell

“…Humans have three functioning genes that encode copper-containing amine oxidases. The product of the AOC1 gene is a so-called diamine oxidase (hDAO), named for…”
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HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis by McGlynn, Shawn E., Shepard, Eric M., Winslow, Mark A., Naumov, Anatoli V., Duschene, Kaitlin S., Posewitz, Matthew C., Broderick, William E., Broderick, Joan B., Peters, John W.

“…In an effort to determine the specific protein component(s) responsible for in vitro activation of the [FeFe] hydrogenase (HydA), the individual maturation…”
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Radical S‑Adenosylmethionine Enzymes by Broderick, Joan B, Duffus, Benjamin R, Duschene, Kaitlin S, Shepard, Eric M

“…Broderick et al investigate radical s-adenosylmethionine (SAM) enzymes and detail their biochemical, structural and mechanistic elements. Strong reducing…”
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Inner-Sphere Mechanism for Molecular Oxygen Reduction Catalyzed by Copper Amine Oxidases by Mukherjee, Arnab, Smirnov, Valeriy V, Lanci, Michael P, Brown, Doreen E, Shepard, Eric M, Dooley, David M, Roth, Justine P

“…Copper and topaquinone (TPQ) containing amine oxidases utilize O2 for the metabolism of biogenic amines while concomitantly generating H2O2 for use by the…”
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Identification and Characterization of a Novel Member of the Radical AdoMet Enzyme Superfamily and Implications for the Biosynthesis of the Hmd Hydrogenase Active Site Cofactor by MCGLYNN, Shawn E, BOYD, Eric S, SHEPARD, Eric M, LANGE, Rachel K, GERLACH, Robin, BRODERICK, Joan B, PETERS, John W

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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[FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation by Peters, John W., Schut, Gerrit J., Boyd, Eric S., Mulder, David W., Shepard, Eric M., Broderick, Joan B., King, Paul W., Adams, Michael W.W.

“…The [FeFe]- and [NiFe]-hydrogenases catalyze the formal interconversion between hydrogen and protons and electrons, possess characteristic non-protein ligands…”
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[FeFe]‐Hydrogenase In Vitro Maturation by Pagnier, Adrien, Balci, Batuhan, Shepard, Eric M., Broderick, William E., Broderick, Joan B.

“…The [FeFe]‐hydrogenase H‐cluster is a complex organometallic cofactor whose assembly and installation requires three dedicated accessory proteins referred to…”
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Inhibition and Oxygen Activation in Copper Amine Oxidases by Shepard, Eric M, Dooley, David M

“…Copper-containing amine oxidases (CuAOs) use both copper and 2,4,5-trihydroxyphenylalanine quinone (TPQ) to catalyze the oxidative deamination of primary…”
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Intramolecular electron transfer rate between active-site copper and TPQ in Arthrobacter globiformis amine oxidase by Shepard, Eric M, Dooley, David M

“…Copper amine oxidases catalyze the oxidative deamination of primary amines operating through a ping-pong bi bi mechanism, divided into reductive and oxidative…”
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Role of ammonia-lyases in the synthesis of the dithiomethylamine ligand during [FeFe]-hydrogenase maturation by Pagnier, Adrien, Balci, Batuhan, Shepard, Eric M., Yang, Hao, Drena, Alex, Holliday, Gemma L., Hoffman, Brian M., Broderick, William E., Broderick, Joan B.

“…The generation of an active [FeFe]-hydrogenase requires the synthesis of a complex metal center, the H-cluster, by three dedicated maturases: the radical…”
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S -Adenosyl-l-ethionine is a Catalytically Competent Analog of S -Adenosyl-l-methione (SAM) in the Radical SAM Enzyme HydG by Impano, Stella, Yang, Hao, Shepard, Eric M, Swimley, Ryan, Pagnier, Adrien, Broderick, William E, Hoffman, Brian M, Broderick, Joan B

“…Radical S-adenosyl-l-methionine (SAM) enzymes initiate biological radical reactions with the 5'-deoxyadenosyl radical (5'-dAdo•). A [4Fe-4S] cluster…”
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Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S‑Adenosylmethionine Derived Methyl Radical by Yang, Hao, Impano, Stella, Shepard, Eric M, James, Christopher D, Broderick, William E, Broderick, Joan B, Hoffman, Brian M

“…Radical SAM (RS) enzymes use S-adenosyl-l-methionine (SAM) and a [4Fe–4S] cluster to initiate a broad spectrum of radical transformations throughout all…”
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