Search Results - "Shenkman, Marina"

Compartmentalization and Selective Tagging for Disposal of Misfolded Glycoproteins by Shenkman, Marina, Lederkremer, Gerardo Z.

“…The ability of mammalian cells to correctly identify and degrade misfolded secretory proteins, most of them bearing N-glycans, is crucial for their correct…”
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The Sigma-1 receptor is an ER-localized type II membrane protein by Sharma, Neeraj, Patel, Chaitanya, Shenkman, Marina, Kessel, Amit, Ben-Tal, Nir, Lederkremer, Gerardo Z.

“…The Sigma-1 receptor (S1R) is a transmembrane protein with important roles in cellular homeostasis in normal physiology and in disease. Especially in…”
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A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models by Ganz, Javier, Shacham, Talya, Kramer, Maria, Shenkman, Marina, Eiger, Hagit, Weinberg, Nitai, Iancovici, Ori, Roy, Somnath, Simhaev, Luba, Da’adoosh, Benny, Engel, Hamutal, Perets, Nisim, Barhum, Yael, Portnoy, Moshe, Offen, Daniel, Lederkremer, Gerardo Z.

“…One of the pathways of the unfolded protein response, initiated by PKR-like endoplasmic reticulum kinase (PERK), is key to neuronal homeostasis in…”
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ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin by Leitman, Julia, Barak, Boaz, Benyair, Ron, Shenkman, Marina, Ashery, Uri, Hartl, F Ulrich, Lederkremer, Gerardo Z

“…A hallmark of Huntington's disease is the pronounced sensitivity of striatal neurons to polyglutamine-expanded huntingtin expression. Here we show that…”
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Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD by Leitman, Julia, Shenkman, Marina, Gofman, Yana, Shtern, Navit Ogen, Ben-Tal, Nir, Hendershot, Linda M, Lederkremer, Gerardo Z

“…A functional unfolded protein response (UPR) is essential for endoplasmic reticulum (ER)-associated degradation (ERAD) of misfolded secretory proteins,…”
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A Shared Endoplasmic Reticulum-associated Degradation Pathway Involving the EDEM1 Protein for Glycosylated and Nonglycosylated Proteins by Shenkman, Marina, Groisman, Bella, Ron, Efrat, Avezov, Edward, Hendershot, Linda M., Lederkremer, Gerardo Z.

“…Studies of misfolded protein targeting to endoplasmic reticulum-associated degradation (ERAD) have largely focused on glycoproteins, which include the bulk of…”
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Mannose Trimming Is Required for Delivery of a Glycoprotein from EDEM1 to XTP3-B and to Late Endoplasmic Reticulum-associated Degradation Steps by Groisman, Bella, Shenkman, Marina, Ron, Efrat, Lederkremer, Gerardo Z.

“…Although the trimming of α1,2-mannose residues from precursor N-linked oligosaccharides is an essential step in the delivery of misfolded glycoproteins to…”
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Oxidoreductases in Glycoprotein Glycosylation, Folding, and ERAD by Patel, Chaitanya, Saad, Haddas, Shenkman, Marina, Lederkremer, Gerardo Z

“…N-linked glycosylation and sugar chain processing, as well as disulfide bond formation, are among the most common post-translational protein modifications…”
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Bypass of glycan-dependent glycoprotein delivery to ERAD by up-regulated EDEM1 by Ron, Efrat, Shenkman, Marina, Groisman, Bella, Izenshtein, Yana, Leitman, Julia, Lederkremer, Gerardo Z

“…Trimming of mannose residues from the N-linked oligosaccharide precursor is a stringent requirement for glycoprotein endoplasmic reticulum (ER)-associated…”
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COP I and II dependent trafficking controls ER-associated degradation in mammalian cells by Ogen-Shtern, Navit, Chang, Chieh, Saad, Haddas, Mazkereth, Niv, Patel, Chaitanya, Shenkman, Marina, Lederkremer, Gerardo Z.

“…Misfolded proteins and components of the endoplasmic reticulum (ER) quality control and ER associated degradation (ERAD) machineries concentrate in mammalian…”
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PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stress by Kondratyev, Maria, Avezov, Edward, Shenkman, Marina, Groisman, Bella, Lederkremer, Gerardo Z.

“…Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the ER membrane kinases PERK and IRE1 leading to the unfolded protein response…”
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[2- 3 H]Mannose-labeling and Analysis of N-linked Oligosaccharides by Shenkman, Marina, Ogen-Shtern, Navit, Lederkremer, Gerardo Z

“…Modifications of N-linked oligosaccharides of glycoproteins soon after their biosynthesis correlate to glycoprotein folding status. These alterations can be…”
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Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis by Benyair, Ron, Kondratyev, Maria, Veselkin, Elena, Tolchinsky, Sandra, Shenkman, Marina, Lurie, Yoav, Lederkremer, Gerardo Z

“…AIM： To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum. METHODS： Production of…”
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A novel quality control compartment derived from the endoplasmic reticulum by Kamhi-Nesher, S, Shenkman, M, Tolchinsky, S, Fromm, S V, Ehrlich, R, Lederkremer, G Z

“…Degradation of proteins that, because of improper or suboptimal processing, are retained in the endoplasmic reticulum (ER) involves retrotranslocation to reach…”
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Transient arrest in proteasomal degradation during inhibition of translation in the unfolded protein response by Shenkman, Marina, Tolchinsky, Sandra, Kondratyev, Maria, Lederkremer, Gerardo Z

“…The UPR (unfolded protein response) activates transcription of genes involved in proteasomal degradation. However, we found that in its early stages the UPR…”
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Pridopidine reduces mutant huntingtin‐induced endoplasmic reticulum stress by modulation of the Sigma‐1 receptor by Shenkman, Marina, Geva, Michal, Gershoni‐Emek, Noga, Hayden, Michael R., Lederkremer, Gerardo Z.

“…The endoplasmic reticulum (ER)‐localized Sigma‐1 receptor (S1R) is neuroprotective in models of neurodegenerative diseases, among them Huntington disease (HD)…”
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Endoplasmic Reticulum Quality Control of Asialoglycoprotein Receptor H2a Involves a Determinant for Retention and not Retrieval by Shenkman, Marina, Ayalon, Michal, Lederkremer, Gerardo Z.

“…The human asialoglycoprotein receptor H2a subunit contains a charged pentapeptide, EGHRG, in its ectodomain that is the only sequence absent from the H2b…”
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Masking of an Endoplasmic Reticulum Retention Signal by Its Presence in the Two Subunits of the Asialoglycoprotein Receptor by Shenkman, Marina, Ehrlich, Marcelo, Lederkremer, Gerardo Z.

“…Human asialoglycoprotein receptor H1 and H2b subunits assemble into a hetero-oligomer that travels to the cell surface. The H2a variant on the other hand is a…”
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Mannosidase IA is in Quality Control Vesicles and Participates in Glycoprotein Targeting to ERAD by Ogen-Shtern, Navit, Avezov, Edward, Shenkman, Marina, Benyair, Ron, Lederkremer, Gerardo Z.

“…Endoplasmic reticulum-associated degradation (ERAD) of a misfolded glycoprotein in mammalian cells requires the removal of 3–4 alpha 1,2 linked mannose…”
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Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling by Lynes, Emily M, Raturi, Arun, Shenkman, Marina, Ortiz Sandoval, Carolina, Yap, Megan C, Wu, Jiahui, Janowicz, Aleksandra, Myhill, Nathan, Benson, Matthew D, Campbell, Robert E, Berthiaume, Luc G, Lederkremer, Gerardo Z, Simmen, Thomas

“…The palmitoylation of calnexin serves to enrich calnexin on the mitochondria-associated membrane (MAM). Given a lack of information on the significance of this…”
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