Search Results - "Shenkman, Boris S."

How Postural Muscle Senses Disuse? Early Signs and Signals by Shenkman, Boris S

“…A mammalian soleus muscle along with other "axial" muscles ensures the stability of the body under the Earth's gravity. In rat experiments with hindlimb…”
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The Role of GSK-3β in the Regulation of Protein Turnover, Myosin Phenotype, and Oxidative Capacity in Skeletal Muscle under Disuse Conditions by Mirzoev, Timur M., Sharlo, Kristina A., Shenkman, Boris S.

“…Skeletal muscles, being one of the most abundant tissues in the body, are involved in many vital processes, such as locomotion, posture maintenance,…”
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Cellular Responses of Human Postural Muscle to Dry Immersion by Shenkman, Boris S, Kozlovskaya, Inessa B

“…Support withdrawal has been currently considered as one of the main factors involved in regulation of the human locomotor system. For last decades, several…”
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AMP-Activated Protein Kinase as a Key Trigger for the Disuse-Induced Skeletal Muscle Remodeling by Vilchinskaya, Natalia A, Krivoi, Igor I, Shenkman, Boris S

“…Molecular mechanisms that trigger disuse-induced postural muscle atrophy as well as myosin phenotype transformations are poorly studied. This review will…”
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Role of Pannexin 1 ATP-Permeable Channels in the Regulation of Signaling Pathways during Skeletal Muscle Unloading by Zaripova, Ksenia A., Kalashnikova, Ekaterina P., Belova, Svetlana P., Kostrominova, Tatiana Y., Shenkman, Boris S., Nemirovskaya, Tatiana L.

“…Skeletal muscle unloading results in atrophy. We hypothesized that pannexin 1 ATP-permeable channel (PANX1) is involved in the response of muscle to unloading…”
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Molecular Signaling Effects behind the Spontaneous Soleus Muscle Activity Induced by 7-Day Rat Hindlimb Suspension by Sergeeva, Xenia V, Sharlo, Kristina A, Tyganov, Sergey A, Kalashnikov, Vitaliy E, Shenkman, Boris S

“…The elimination of ground reaction force (support withdrawal) vastly affects slow postural muscles in terms of their regulation and structure. One of the…”
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Metformin Attenuates Slow-to-Fast Fiber Shift and Proteolysis Markers Increase in Rat Soleus after 7 Days of Rat Hindlimb Unloading by Sharlo, Kristina A, Lvova, Irina D, Belova, Svetlana P, Zaripova, Ksenia A, Shenkman, Boris S, Nemirovskaya, Tatiana L

“…Muscle unloading leads to signaling alterations that cause muscle atrophy and weakness. The cellular energy sensor AMPK can regulate myofiber-type shift,…”
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Effects of Various Muscle Disuse States and Countermeasures on Muscle Molecular Signaling by Sharlo, Kristina, Tyganov, Sergey A, Tomilovskaya, Elena, Popov, Daniil V, Saveko, Alina A, Shenkman, Boris S

“…Skeletal muscle is capable of changing its structural parameters, metabolic rate and functional characteristics within a wide range when adapting to various…”
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The Role of Glycogen Synthase Kinase-3 in the Regulation of Ribosome Biogenesis in Rat Soleus Muscle under Disuse Conditions by Rozhkov, Sergey V, Sharlo, Kristina A, Shenkman, Boris S, Mirzoev, Timur M

“…It is well-established that prolonged exposure to real or simulated microgravity/disuse conditions results in a significant reduction in the rate of muscle…”
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Changes in the Mechanical Properties of Fast and Slow Skeletal Muscle after 7 and 21 Days of Restricted Activity in Rats by Tyganov, Sergey A, Belova, Svetlana P, Turtikova, Olga V, Vikhlyantsev, Ivan M, Nemirovskaya, Tatiana L, Shenkman, Boris S

“…Disuse muscle atrophy is usually accompanied by changes in skeletal muscle structure, signaling, and contractile potential. Different models of muscle…”
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Temporal changes in the markers of ribosome biogenesis in rat soleus muscle under simulated microgravity by Rozhkov, Sergey V., Sharlo, Kristina A., Mirzoev, Timur M., Shenkman, Boris S.

“…Skeletal muscle inactivity due to real or simulated microgravity results in a significant atrophy of muscle fibers. One of the key causes of disuse atrophy is…”
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HDAC4 Is Indispensable for Reduced Slow Myosin Expression at the Early Stage of Hindlimb Unloading in Rat Soleus Muscle by Paramonova, Inna I., Vilchinskaya, Natalia A., Shenkman, Boris S.

“…It is well known that reduced contractile activity of the main postural soleus muscle during long-term bedrest, immobilization, hindlimb unloading, and space…”
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Chronic Ouabain Prevents Na,K-ATPase Dysfunction and Targets AMPK and IL-6 in Disused Rat Soleus Muscle by Kravtsova, Violetta V, Paramonova, Inna I, Vilchinskaya, Natalia A, Tishkova, Maria V, Matchkov, Vladimir V, Shenkman, Boris S, Krivoi, Igor I

“…Sustained sarcolemma depolarization due to loss of the Na,K-ATPase function is characteristic for skeletal muscle motor dysfunction. Ouabain, a specific ligand…”
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Cultured Myoblasts Derived from Rat Soleus Muscle Show Altered Regulation of Proliferation and Myogenesis during the Course of Mechanical Unloading by Komarova, Margarita Y., Rozhkov, Sergey V., Ivanova, Oksana A., Turtikova, Olga V., Mirzoev, Timur M., Dmitrieva, Renata I., Shenkman, Boris S., Vilchinskaya, Natalia A.

“…The structure and function of soleus muscle fibers undergo substantial remodeling under real or simulated microgravity conditions. However, unloading-induced…”
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Differences in the Role of HDACs 4 and 5 in the Modulation of Processes Regulating MAFbx and MuRF1 Expression during Muscle Unloading by Mochalova, Ekaterina P, Belova, Svetlana P, Kostrominova, Tatiana Y, Shenkman, Boris S, Nemirovskaya, Tatiana L

“…Unloading leads to skeletal muscle atrophy via the upregulation of MuRF-1 and MAFbx E3-ligases expression. Reportedly, histone deacetylases (HDACs) 4 and 5 may…”
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P38α-MAPK Signaling Inhibition Attenuates Soleus Atrophy during Early Stages of Muscle Unloading by Belova, Svetlana P, Mochalova, Ekaterina P, Kostrominova, Tatiana Y, Shenkman, Boris S, Nemirovskaya, Tatiana L

“…To test the hypothesis that p38α-MAPK plays a critical role in the regulation of E3 ligase expression and skeletal muscle atrophy during unloading, we used…”
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Plantar Mechanical Stimulation Maintains Slow Myosin Expression in Disused Rat Soleus Muscle via NO-Dependent Signaling by Sharlo, Kristina A, Paramonova, Inna I, Lvova, Irina D, Mochalova, Ekaterina P, Kalashnikov, Vitaliy E, Vilchinskaya, Natalia A, Tyganov, Sergey A, Konstantinova, Tatyana S, Shevchenko, Tatiana F, Kalamkarov, Grigoriy R, Shenkman, Boris S

“…It was observed that gravitational unloading during space missions and simulated microgravity in ground-based studies leads to both transformation of…”
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NO-Dependent Mechanisms of Myosin Heavy Chain Transcription Regulation in Rat Soleus Muscle After 7-Days Hindlimb Unloading by Sharlo, Kristina A, Paramonova, Inna I, Lvova, Irina D, Vilchinskaya, Natalia A, Bugrova, Anna E, Shevchenko, Tatiana F, Kalamkarov, Grigoriy R, Shenkman, Boris S

“…It is known that nitric oxide (NO) may affect myosin heavy chain (MyHC) isoform mRNA transcription in skeletal muscles. The content of NO in soleus muscles…”
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Metformin Pre-Treatment as a Means of Mitigating Disuse-Induced Rat Soleus Muscle Wasting by Mirzoev, Timur M, Paramonova, Inna I, Rozhkov, Sergey V, Kalashnikova, Ekaterina P, Belova, Svetlana P, Tyganov, Sergey A, Vilchinskaya, Natalia A, Shenkman, Boris S

“…Currently, no ideal treatment exists to combat skeletal muscle disuse-induced atrophy and loss of strength. Because the activity of AMP-activated protein…”
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Effects of Plantar Mechanical Stimulation on Anabolic and Catabolic Signaling in Rat Postural Muscle Under Short-Term Simulated Gravitational Unloading by Tyganov, Sergey A., Mochalova, Ekaterina P., Belova, Svetlana P., Sharlo, Kristina A., Rozhkov, Sergey V., Vilchinskaya, Natalia A., Paramonova, Inna I., Mirzoev, Timur M., Shenkman, Boris S.

“…It is known that plantar mechanical stimulation (PMS) is able to attenuate unloading-induced skeletal muscle atrophy and impaired muscle function. However,…”
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