Search Results - "Shengjuler, Djoshkun"
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Defective viral genomes as therapeutic interfering particles against flavivirus infection in mammalian and mosquito hosts
Published in Nature communications (16-04-2021)“…Arthropod-borne viruses pose a major threat to global public health. Thus, innovative strategies for their control and prevention are urgently needed. Here, we…”
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The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D
Published in PLoS biology (23-01-2023)“…RNA recombination in positive-strand RNA viruses is a molecular-genetic process, which permits the greatest evolution of the genome and may be essential to…”
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Structure-function analysis of vaccinia virus H7 protein reveals a novel phosphoinositide binding fold essential for poxvirus replication
Published in Journal of virology (01-02-2015)“…Phosphoinositides and phosphoinositide binding proteins play a critical role in membrane and protein trafficking in eukaryotes. Their critical role in…”
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Published in Nature (London) (16-07-2020)“…A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019…”
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Characterization of Protein-Phospholipid/Membrane Interactions Using a "Membrane-on-a-Chip" Microfluidic System
Published in Methods in molecular biology (Clifton, N.J.) (2021)“…It is now clear that organelles of a mammalian cell can be distinguished by phospholipid profiles, both as ratios of common phospholipids and by the absence or…”
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Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses
Published in Molecular cell (04-11-2021)“…Viral RNA-dependent RNA polymerases (RdRps) are a target for broad-spectrum antiviral therapeutic agents. Recently, we demonstrated that incorporation of the…”
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An alphavirus-derived self-amplifying mRNA encoding PpSP15-LmSTI1 fusion protein for the design of a vaccine against leishmaniasis
Published in Parasitology international (01-08-2022)“…The main aims of the present study were to design a fusion protein of Leishmania major stress-inducible protein 1 (LmSTI1) and Phlebotomus papatasi SP15…”
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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
Published in Journal of visualized experiments (27-07-2017)Get full text
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The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain
Published in Structure (London) (05-12-2017)“…Some viruses use phosphatidylinositol phosphate (PIP) to mark membranes used for genome replication or virion assembly. PIP-binding motifs of cellular proteins…”
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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
Published in Journal of visualized experiments (27-07-2017)“…Numerous cellular proteins interact with membrane surfaces to affect essential cellular processes. These interactions can be directed towards a specific lipid…”
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Targeting Viral Proteins to Sites of Genome Replication: Discovery and Characterization of Viral Phosphoinositide-Binding Domains
Published 01-01-2017“…How viral proteins are targeted specifically to sites of genome replication is a longstanding question in virology. All positive-strand RNA viruses reorganize…”
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Dissertation -
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On the Role of Protein 3CD in Formation of the Poliovirus Replication Organelle
Published in Biophysical journal (29-01-2013)Get full text
Journal Article