Search Results - "Sheng, Zizhang"

Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5 by Wang, Qian, Guo, Yicheng, Iketani, Sho, Nair, Manoj S., Li, Zhiteng, Mohri, Hiroshi, Wang, Maple, Yu, Jian, Bowen, Anthony D., Chang, Jennifer Y., Shah, Jayesh G., Nguyen, Nadia, Chen, Zhiwei, Meyers, Kathrine, Yin, Michael T., Sobieszczyk, Magdalena E., Sheng, Zizhang, Huang, Yaoxing, Liu, Lihong, Ho, David D.

“…SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 have surged notably to become dominant in the United States and South Africa, respectively 1 , 2 . These…”
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Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 by Wang, Pengfei, Nair, Manoj S., Liu, Lihong, Iketani, Sho, Luo, Yang, Guo, Yicheng, Wang, Maple, Yu, Jian, Zhang, Baoshan, Kwong, Peter D., Graham, Barney S., Mascola, John R., Chang, Jennifer Y., Yin, Michael T., Sobieszczyk, Magdalena, Kyratsous, Christos A., Shapiro, Lawrence, Sheng, Zizhang, Huang, Yaoxing, Ho, David D.

“…The COVID-19 pandemic has had widespread effects across the globe, and its causative agent, SARS-CoV-2, continues to spread. Effective interventions need to be…”
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Antibody evasion properties of SARS-CoV-2 Omicron sublineages by Iketani, Sho, Liu, Lihong, Guo, Yicheng, Liu, Liyuan, Chan, Jasper F.-W., Huang, Yiming, Wang, Maple, Luo, Yang, Yu, Jian, Chu, Hin, Chik, Kenn K.-H., Yuen, Terrence T.-T., Yin, Michael T., Sobieszczyk, Magdalena E., Huang, Yaoxing, Yuen, Kwok-Yung, Wang, Harris H., Sheng, Zizhang, Ho, David D.

“…The identification of the Omicron (B.1.1.529.1 or BA.1) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Botswana in November 2021 1…”
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Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir by Iketani, Sho, Mohri, Hiroshi, Culbertson, Bruce, Hong, Seo Jung, Duan, Yinkai, Luck, Maria I., Annavajhala, Medini K., Guo, Yicheng, Sheng, Zizhang, Uhlemann, Anne-Catrin, Goff, Stephen P., Sabo, Yosef, Yang, Haitao, Chavez, Alejandro, Ho, David D.

“…Nirmatrelvir, an oral antiviral targeting the 3CL protease of SARS-CoV-2, has been demonstrated to be clinically useful against COVID-19 (refs. 1 , 2 )…”
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Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA.2.75 by Wang, Qian, Iketani, Sho, Li, Zhiteng, Guo, Yicheng, Yeh, Andre Yanchen, Liu, Michael, Yu, Jian, Sheng, Zizhang, Huang, Yaoxing, Liu, Lihong, Ho, David D.

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant BA.2.75 emerged recently and appears to be spreading. It has nine mutations…”
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Cryo-EM structure of the SARS-CoV-2 Omicron spike by Cerutti, Gabriele, Guo, Yicheng, Liu, Lihong, Liu, Liyuan, Zhang, Zhening, Luo, Yang, Huang, Yiming, Wang, Harris H., Ho, David D., Sheng, Zizhang, Shapiro, Lawrence

“…The recently reported B.1.1.529 Omicron variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) includes 34 mutations in the spike protein…”
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Cocirculation of two distinct genetic and antigenic lineages of proposed influenza D virus in cattle by Collin, Emily A, Sheng, Zizhang, Lang, Yuekun, Ma, Wenjun, Hause, Ben M, Li, Feng

“…Viruses with approximately 50% homology to human influenza C virus (ICV) have recently been isolated from swine and cattle. The overall low homology to ICV,…”
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cAb-Rep: A Database of Curated Antibody Repertoires for Exploring Antibody Diversity and Predicting Antibody Prevalence by Guo, Yicheng, Chen, Kevin, Kwong, Peter D, Shapiro, Lawrence, Sheng, Zizhang

“…The diversity of B cell receptors provides a basis for recognizing numerous pathogens. Antibody repertoire sequencing has revealed relationships between B cell…”
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Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody by Bonsignori, Mattia, Zhou, Tongqing, Sheng, Zizhang, Chen, Lei, Gao, Feng, Joyce, M. Gordon, Ozorowski, Gabriel, Chuang, Gwo-Yu, Schramm, Chaim A., Wiehe, Kevin, Alam, S. Munir, Bradley, Todd, Gladden, Morgan A., Hwang, Kwan-Ki, Iyengar, Sheelah, Kumar, Amit, Lu, Xiaozhi, Luo, Kan, Mangiapani, Michael C., Parks, Robert J., Song, Hongshuo, Acharya, Priyamvada, Bailer, Robert T., Cao, Allen, Druz, Aliaksandr, Georgiev, Ivelin S., Kwon, Young D., Louder, Mark K., Zhang, Baoshan, Zheng, Anqi, Hill, Brenna J., Kong, Rui, Soto, Cinque, Mullikin, James C., Douek, Daniel C., Montefiori, David C., Moody, Michael A., Shaw, George M., Hahn, Beatrice H., Kelsoe, Garnett, Hraber, Peter T., Korber, Bette T., Boyd, Scott D., Fire, Andrew Z., Kepler, Thomas B., Shapiro, Lawrence, Ward, Andrew B., Mascola, John R., Liao, Hua-Xin, Kwong, Peter D., Haynes, Barton F.

“…Antibodies with ontogenies from VH1-2 or VH1-46-germline genes dominate the broadly neutralizing response against the CD4-binding site (CD4bs) on HIV-1. Here,…”
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Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection by Wu, Xueling, Zhang, Zhenhai, Schramm, Chaim A, Joyce, M Gordon, Kwon, Young Do, Zhou, Tongqing, Sheng, Zizhang, Zhang, Baoshan, O'Dell, Sijy, McKee, Krisha, Georgiev, Ivelin S, Chuang, Gwo-Yu, Longo, Nancy S, Lynch, Rebecca M, Saunders, Kevin O, Soto, Cinque, Srivatsan, Sanjay, Yang, Yongping, Bailer, Robert T, Louder, Mark K, Mullikin, James C, Connors, Mark, Kwong, Peter D, Mascola, John R, Shapiro, Lawrence

“…HIV-1-neutralizing antibodies develop in most HIV-1-infected individuals, although highly effective antibodies are generally observed only after years of…”
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Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses by Hause, Ben M, Ducatez, Mariette, Collin, Emily A, Ran, Zhiguang, Liu, Runxia, Sheng, Zizhang, Armien, Anibal, Kaplan, Bryan, Chakravarty, Suvobrata, Hoppe, Adam D, Webby, Richard J, Simonson, Randy R, Li, Feng

“…Of the Orthomyxoviridae family of viruses, only influenza A viruses are thought to exist as multiple subtypes and has non-human maintenance hosts. In April…”
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Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition by Chuang, Gwo-Yu, Zhou, Jing, Acharya, Priyamvada, Rawi, Reda, Shen, Chen-Hsiang, Sheng, Zizhang, Zhang, Baoshan, Zhou, Tongqing, Bailer, Robert T., Dandey, Venkata P., Doria-Rose, Nicole A., Louder, Mark K., McKee, Krisha, Mascola, John R., Shapiro, Lawrence, Kwong, Peter D.

“…Over the past decade, structures have been determined for broadly neutralizing antibodies that recognize all major exposed surfaces of the prefusion-closed…”
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Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain by Cerutti, Gabriele, Guo, Yicheng, Wang, Pengfei, Nair, Manoj S., Wang, Maple, Huang, Yaoxing, Yu, Jian, Liu, Lihong, Katsamba, Phinikoula S., Bahna, Fabiana, Reddem, Eswar R., Kwong, Peter D., Ho, David D., Sheng, Zizhang, Shapiro, Lawrence

“…Antibodies that potently neutralize SARS-CoV-2 target mainly the receptor-binding domain or the N-terminal domain (NTD). Over a dozen potently neutralizing…”
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Influenza A Virus Antibodies with Antibody-Dependent Cellular Cytotoxicity Function by Gao, Rongyuan, Sheng, Zizhang, Sreenivasan, Chithra C, Wang, Dan, Li, Feng

“…Influenza causes millions of cases of hospitalizations annually and remains a public health concern on a global scale. Vaccines are developed and have proven…”
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Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class by Rapp, Micah, Guo, Yicheng, Reddem, Eswar R., Yu, Jian, Liu, Lihong, Wang, Pengfei, Cerutti, Gabriele, Katsamba, Phinikoula, Bimela, Jude S., Bahna, Fabiana A., Mannepalli, Seetha M., Zhang, Baoshan, Kwong, Peter D., Huang, Yaoxing, Ho, David D., Shapiro, Lawrence, Sheng, Zizhang

“…Antibodies with heavy chains that derive from the VH1-2 gene constitute some of the most potent severe acute respiratory syndrome coronavirus 2…”
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Replication and Transmission of the Novel Bovine Influenza D Virus in a Guinea Pig Model by Sreenivasan, Chithra, Thomas, Milton, Sheng, Zizhang, Hause, Ben M, Collin, Emily A, Knudsen, David E B, Pillatzki, Angela, Nelson, Eric, Wang, Dan, Kaushik, Radhey S, Li, Feng

“…Influenza D virus (FLUDV) is a novel influenza virus that infects cattle and swine. The goal of this study was to investigate the replication and transmission…”
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Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation by Sheng, Zizhang, Schramm, Chaim A, Kong, Rui, Mullikin, James C, Mascola, John R, Kwong, Peter D, Shapiro, Lawrence

“…Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous…”
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Development and Characterization of a Reverse-Genetics System for Influenza D Virus by Yu, Jieshi, Liu, Runxia, Zhou, Bin, Chou, Tsui-Wen, Ghedin, Elodie, Sheng, Zizhang, Gao, Rongyuan, Zhai, Shao-Lun, Wang, Dan, Li, Feng

“…Influenza D virus (IDV) of the family has a wide host range and a broad geographical distribution. Recent IDV outbreaks in swine along with serological and…”
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SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts by Schramm, Chaim A, Sheng, Zizhang, Zhang, Zhenhai, Mascola, John R, Kwong, Peter D, Shapiro, Lawrence

“…The rapid advance of massively parallel or next-generation sequencing technologies has made possible the characterization of B cell receptor repertoires in…”
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Analysis of immunoglobulin transcripts and hypermutation following SHIVAD8 infection and protein-plus-adjuvant immunization by Francica, Joseph R., Sheng, Zizhang, Zhang, Zhenhai, Nishimura, Yoshiaki, Shingai, Masashi, Ramesh, Akshaya, Keele, Brandon F., Schmidt, Stephen D., Flynn, Barbara J., Darko, Sam, Lynch, Rebecca M., Yamamoto, Takuya, Matus-Nicodemos, Rodrigo, Wolinsky, David, Nason, Martha, Valiante, Nicholas M., Malyala, Padma, De Gregorio, Ennio, Barnett, Susan W., Singh, Manmohan, O’Hagan, Derek T., Koup, Richard A., Mascola, John R., Martin, Malcolm A., Kepler, Thomas B., Douek, Daniel C., Shapiro, Lawrence, Seder, Robert A.

“…Developing predictive animal models to assess how candidate vaccines and infection influence the ontogenies of Envelope (Env)-specific antibodies is critical…”
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