Search Results - "Shenfei Sun"
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Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
Published in Nature communications (06-03-2019)“…Lgr5+ stem cells are crucial to gut epithelium homeostasis; however, how these cells are maintained is not fully understood. Zinc finger HIT-type containing 1…”
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Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers
Published in Leukemia (01-12-2020)“…Hematopoietic stem cell (HSC) utilizes its quiescence feature to combat exhaustion for lifetime blood cell supply. To date, how certain chromatin architecture…”
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Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development
Published in PLoS genetics (01-08-2017)“…The tree-like structure of the mammalian lung is generated from branching morphogenesis, a reiterative process that is precisely regulated by numerous factors…”
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Chromatin remodeler Dmp18 regulates apoptosis by controlling H2Av incorporation in Drosophila imaginal disc development
Published in PLoS genetics (27-09-2022)“…Programmed Cell Death (PCD) or apoptosis is a highly conserved biological process and plays essential roles both in the development and stress context. In…”
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A novel posttranslational modification of histone, H3 S-sulfhydration, is down-regulated in asthenozoospermic sperm
Published in Journal of assisted reproduction and genetics (01-12-2021)“…Oxidative stress is one of the major causes leading to male infertility including asthenozoospermia. Hydrogen sulfide (H 2 S) has been widely recognized to be…”
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UHRF1-repressed 5’-hydroxymethylcytosine is essential for the male meiotic prophase I
Published in Cell death & disease (21-02-2020)“…5’-hydroxymethylcytosine (5hmC), an important 5’-cytosine modification, is altered highly in order in male meiotic prophase. However, the regulatory mechanism…”
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Lgr4 Regulates Oviductal Epithelial Secretion Through the WNT Signaling Pathway
Published in Frontiers in cell and developmental biology (24-09-2021)“…The WNT signaling pathway plays a crucial role in oviduct/fallopian development. However, the specific physiological processes regulated by the WNT pathway in…”
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Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression
Published in Developmental cell (11-04-2022)“…The switch from mitosis to meiosis ensures the successive formation of gametes. However, it remains unclear how meiotic initiation occurs within the context of…”
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Chromatin remodeler Dmp18 regulates apoptosis by controlling H2Av incorporation in Drosophila imaginal disc development
Published in PLoS genetics (01-09-2022)“…Programmed Cell Death (PCD) or apoptosis is a highly conserved biological process and plays essential roles both in the development and stress context. In…”
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10
Chronic exposure to diesel exhaust particulate matter impairs meiotic progression during spermatogenesis in a mouse model
Published in Ecotoxicology and environmental safety (01-10-2020)“…Exposure to ambient PM2.5 may correlate with the decline of semen quality, and the underlying biological mechanism has not been fully understood. In the…”
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Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching
Published in The Journal of biological chemistry (01-10-2022)“…Branching morphogenesis is a key process essential for lung and other organ development in which cellular and tissue architecture branch out to maximize…”
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Znhit1-mediated H2A.Z incorporation is essential for Lgr5 + intestinal stem cell specification
Published in Mechanisms of development (01-07-2017)Get full text
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