Search Results - "Shen, Yuelei"

SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape by Li, Qianqian, Nie, Jianhui, Wu, Jiajing, Zhang, Li, Ding, Ruxia, Wang, Haixin, Zhang, Yue, Li, Tao, Liu, Shuo, Zhang, Mengyi, Zhao, Chenyan, Liu, Huan, Nie, Lingling, Qin, Haiyang, Wang, Meng, Lu, Qiong, Li, Xiaoyu, Liu, Junkai, Liang, Haoyu, Shi, Yi, Shen, Yuelei, Xie, Liangzhi, Zhang, Linqi, Qu, Xiaowang, Xu, Wenbo, Huang, Weijin, Wang, Youchun

“…The 501Y.V2 variants of SARS-CoV-2 containing multiple mutations in spike are now dominant in South Africa and are rapidly spreading to other countries. Here,…”
Get full text

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function by Zhou, Liang, Lopes, Jared E., Chong, Mark M. W., Ivanov, Ivaylo I., Min, Roy, Victora, Gabriel D., Shen, Yuelei, Du, Jianguang, Rubtsov, Yuri P., Rudensky, Alexander Y., Ziegler, Steven F., Littman, Dan R.

“…The cytokine TFG-β contributes to the differentiation of both regulatory T cells and T H 17 cells. This paper shows that in intestinal lamina propria cell…”
Get full text

12 Humanized CD200/CD200R mice as a tool for evaluating novel therapeutics by Lv, Ruili, Li, Chong, Shen, Zhiyuan, Wang, Qiurong, Shen, Yuelei

“…BackgroundTumor-associated myeloid cells (TAMCs) represent a diverse population of immune cells capable of regulating tumor growth and progression via…”
Get full text

19 Preclinical CD3-based mouse models for evaluation of bi-specific T-cell engager antibodies by Shang, Chengzhang, Li, Chong, Liu, Chang, Zhang, Jay, Shen, Yuelei

“…BackgroundThe T-cell receptor (TCR)- CD3 complex plays a critical role in mediating T-cell activation and cellular immune response. Key signaling subunits of…”
Get full text

17 Humanized NKP46 mouse models for testing novel NK cell-based immunotherapies by Niu, Zhenlan, Zhou, Xiaofei, Li, Yongshun, Jin, James, Shen, Yuelei

“…BackgroundNKP46 is a key activating receptor on the surface of human NK cells that can trigger NK-mediated killing activity. While stimulation of NKP46…”
Get full text

13 Development of a preclinical CD98HC mouse model for therapeutic studies by Lv, Ruili, Shen, Zhiyuan, Li, Chong, Marchi, Natalie, Shen, Yuelei

“…BackgroundAngiogenesis is essential for many developmental and pathological processes, is dependent on endothelial cell proliferation and migration, and is…”
Get full text

18 Generation and validation of humanized GARP/TGFB1 mice for testing novel anti-human GARP antibodies by Niu, Zhenlan, Zhou, Xiaofei, Lv, Ruili, Li, Jianing, Shen, Yuelei

“…BackgroundCheckpoint inhibitors targeting PD-1 or PD-L1 are at the forefront of cancer immunotherapy, however, treating tumors that have primary or acquired…”
Get full text

Rosa26-targeted sheep gene knock-in via CRISPR-Cas9 system by Wu, Mingming, Wei, Caihong, Lian, Zhengxing, Liu, Ruizao, Zhu, Caiye, Wang, Huihua, Cao, Jiaxue, Shen, Yuelei, Zhao, Fuping, Zhang, Li, Mu, Zhu, Wang, Yayu, Wang, Xiaogang, Du, Lixin, Wang, Chuduan

“…Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering,…”
Get full text

Generation of a uniform thymic malignant lymphoma model with C57BL/6J p53 gene deficient mice by Liu, Susu, Lyu, Jianjun, Li, Qianqian, Wu, Xi, Yang, Yanwei, Huo, Guitao, Zhu, Qingfen, Guo, Ming, Shen, Yuelei, Wang, Sanlong, Fan, Changfa

“…Lymphoma is the third most common cancer diagnosed in children, and T-cell lymphoma has the worst prognosis based on clinical observations. To date, a lymphoma…”
Get full text

11 Humanized ICOS mice as a novel tool for predicting and monitoring T-cell-mediated immunotherapy response by Lv, Ruili, Zhang, Zan, Guo, Jing, Li, Chong, Chhabra, Ravneet, Shen, Yuelei

“…BackgroundThe clinical response rate to checkpoint inhibitors can vary due to disease heterogeneity and complex tumor escape mechanisms, necessitating a need…”
Get full text

16 A novel B2m-deficient immunodeficient model expressing human IL15 for preclinical evaluation of T cell and NK cell-based therapies by Nie, Yanhui, Zhou, Xiaofei, Nerle, Sujata, Liu, Qiang, Yuan, Jiangfeng, Shen, Yuelei

“…BackgroundNatural killer (NK) cells and T cells are important therapeutic populations that can target and eliminate cancer cells. Although human NK/T cell…”
Get full text

Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses by Nie, Jianhui, Li, Qianqian, Zhang, Li, Cao, Yang, Zhang, Yue, Li, Tao, Wu, Jiajing, Liu, Shuo, Zhang, Mengyi, Zhao, Chenyan, Liu, Huan, Nie, Lingling, Qin, Haiyang, Wang, Meng, Lu, Qiong, Li, Xiaoyu, Liu, Junkai, Liang, Haoyu, Jiang, Taijiao, Duan, Kai, Yang, Xiaoming, Shen, Yuelei, Huang, Weijin, Wang, Youchun

“…The origin and intermediate host for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is yet to be determined. Coronaviruses found to be closely…”
Get full text

Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants by Nie, Jianhui, Xie, Jingshu, Liu, Shuo, Wu, Jiajing, Liu, Chuan, Li, Jianhui, Liu, Yacui, Wang, Meiyu, Zhao, Huizhen, Zhang, Yabo, Yao, Jiawei, Chen, Lei, Shen, Yuelei, Yang, Yi, Wang, Hong-Wei, Wang, Youchun, Huang, Weijin

“…Coronavirus disease 2019 (COVID-19), a pandemic disease caused by the newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused…”
Get full text

1150 DM005, an EGFR × MET bispecific antibody-drug conjugate, showed robust anti-tumor activity in PDX models by Han, Yanfei, Dai, Wenjuan, Shang, Chengzhang, Li, Zhuolin, Han, Zhenyan, Li, Jun, Cui, Zixu, An, Gao, Hao, Wanjun, Liu, Yujie, Li, Hao, Liu, Baihong, Frank An, W, Guo, Chaoshe, Yang, Yi, Shen, Yuelei

“…BackgroundBispecific antibodies (BsAb) that target dual tumor-associated antigens can invoke synergistic effects between two signaling pathways, increase…”
Get full text

Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy by Xu, Cassie, Shen, Yuelei, Littman, Dan R., Dustin, Michael L., Velázquez, Peter

“…Intact vascular perfusion done while intravitally visualizing the intestine: mucosal DCs and T cells display activity similar to that found in secondary…”
Get full text

The Cytosolic Endopeptidase, Thimet Oligopeptidase, Destroys Antigenic Peptides and Limits the Extent of MHC Class I Antigen Presentation by York, Ian A., Mo, Annie X.Y., Lemerise, Kristen, Zeng, Wanyong, Shen, Yuelei, Abraham, Carmela R., Saric, Tomo, Goldberg, Alfred L., Rock, Kenneth L.

“…Most antigenic peptides presented on MHC class I molecules are generated by proteasomes during protein breakdown. It is unknown whether these peptides are…”
Get full text

Online Feedback Dead Time Compensation Strategy for Three-Level T-Type Inverters by Wang, Dafang, Wang, Mingyu, Shen, Yuelei, Li, Qi, Liang, Xiu

“…The insertion of dead time will lead to the distortion of output waveforms, which seriously affects the characteristics of the ac induction motor control…”
Get full text

Abstract 2950: Humanized C5AR1 mouse model (B-hC5AR1 mice) for evaluation of anti-C5AR1 mAb in vivo efficacy by Nie, Yanhui, Zhou, Xiaofei, Zhang, Jing, Chromikova, Veronika, Shen, Yuelei

“…Abstract C5AR1 (complement C5a receptor 1) is a classical G protein-coupled receptor that is mainly expressed on granulocytes, monocytes, dendritic cells and…”
Get full text

Abstract 1632: Long-term maintenance of human mature NK cells from hCD34+HSCs engraftment supported by immune humanized B-NDG hIL15 mice by Lin, Qingcong, Hu, Yuting, Zhou, Xiaofei, Su, Youhong, Shen, Yuelei

“…Abstract Human HSC (hematopoietic stem cells) engrafted humanized mice are a powerful model that allows researchers to examine the human immune system and…”
Get full text

Abstract 589: Immune biomarker profiling and safety evaluation response to 4-1BB antibody (Urelumab) in humanized 4-1BB mice by Xiang, Jie, Li, Dirui, Yang, Hao, Ng, Gary, Shen, Yuelei

“…Abstract 4-1BB (CD137) belongs to the TNFR superfamily and is expressed by activated CD4 helper T cells, B cells, natural killer cells, natural killer T cells,…”
Get full text