Search Results - "Shen, Xiulong"

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs by Shen, Xiulong, Corey, David R

“…Abstract RNA plays a central role in the expression of all genes. Because any sequence within RNA can be recognized by complementary base pairing, synthetic…”
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Difficulties translating antisense-mediated activation of Frataxin expression from cell culture to mice by Kilikevicius, Audrius, Wang, Jun, Shen, Xiulong, Rigo, Frank, Prakash, Thahza P., Napierala, Marek, Corey, David R.

“…Friedreich's ataxia (FA) is an inherited neurodegenerative disorder caused by decreased expression of frataxin (FXN) protein. Previous studies have shown that…”
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The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders by Li, Xiang, Kheirabadi, Mahboubeh, Dougherty, Patrick G., Kamer, Kimberli J., Shen, Xiulong, Estrella, Nelsa L., Peddigari, Suresh, Pathak, Anushree, Blake, Sara L., Sizensky, Emmanuelle, Genio, Carmen del, Gaur, Arti B., Dhanabal, Mohanraj, Girgenrath, Mahasweta, Sethuraman, Natarajan, Qian, Ziqing

“…Biological therapeutic agents are highly targeted and potent but limited in their ability to reach intracellular targets. These limitations often necessitate…”
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Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates by Hu, Jiaxin, Shen, Xiulong, Kheirabadi, Mahboubeh, Streeter, Matthew D., Qian, Ziqing, Mootha, V. Vinod, Corey, David R.

“…Fuchs’ corneal endothelial dystrophy (FECD) is a major cause of vision loss. Corneal transplantation is the only effective curative treatment, but this surgery…”
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Enzyme-Activated Generation of Reactive Oxygen Species from Heterocyclic N‑Oxides under Aerobic and Anaerobic Conditions and Its Relevance to Hypoxia-Selective Prodrugs by Shen, Xiulong, Gates, Kent S

“…Enzymatic one-electron reduction of heterocyclic N-oxides can lead to the intracellular generation of reactive oxygen species via several different chemical…”
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Efficient electroporation of neuronal cells using synthetic oligonucleotides: identifying duplex RNA and antisense oligonucleotide activators of human frataxin expression by Shen, Xiulong, Beasley, Sharon, Putman, Jennifer N, Li, Yanjie, Prakash, Thahza P, Rigo, Frank, Napierala, Marek, Corey, David R

“…Oligonucleotide drugs are experiencing greater success in the clinic, encouraging the initiation of new projects. Resources are insufficient to develop every…”
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Progress towards drug discovery for Friedreich’s Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein by Shen, Xiulong, Wong, Johnathan, Prakash, Thahza P., Rigo, Frank, Li, Yanjie, Napierala, Marek, Corey, David R.

“…[Display omitted] Friedreich’s Ataxia (FRDA) is an incurable genetic disease caused by an expanded trinucleotide AAG repeat within intronic RNA of the frataxin…”
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Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion by Shen, Xiulong, Kilikevicius, Audrius, O'Reilly, Daniel, Prakash, Thazha P., Damha, Masad J., Rigo, Frank, Corey, David R.

“…[Display omitted] •Frataxin expression can be activated by single-stranded RNAs.•Activation can be achieved in multiple patient-derived cell lines.•ss-siRNAs…”
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Targeting 3′ and 5′ untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression by Li, Yanjie, Li, Jixue, Wang, Jun, Lynch, David R, Shen, Xiulong, Corey, David R, Parekh, Darshan, Bhat, Balkrishen, Woo, Caroline, Cherry, Jonathan J, Napierala, Jill S, Napierala, Marek

“…Abstract Friedreich’s ataxia (FRDA) is a severe multisystem disease caused by transcriptional repression induced by expanded GAA repeats located in intron 1 of…”
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Generation of DNA-Damaging Reactive Oxygen Species via the Autoxidation of Hydrogen Sulfide under Physiologically Relevant Conditions: Chemistry Relevant to Both the Genotoxic and Cell Signaling Properties of H2S by Hoffman, Marjorie, Rajapakse, Anuruddha, Shen, Xiulong, Gates, Kent S

“…Hydrogen sulfide (H2S) has long been known for its toxic properties; however, in recent years, evidence has emerged that this small, gaseous molecule may serve…”
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Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive Activation of Hypoxia-Selective Anticancer Prodrugs by Shen, Xiulong, Laber, Charles H, Sarkar, Ujjal, Galazzi, Fabio, Johnson, Kevin M, Mahieu, Nathaniel G, Hillebrand, Roman, Fuchs-Knotts, Tarra, Barnes, Charles L, Baker, Gary A, Gates, Kent S

“…Hypoxia-selective cytotoxins (HSCs) seek to exploit the oxygen-poor nature of tumor tissue for therapeutic gain. Typically, HSCs require activation by…”
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Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat by Li, Liande, Shen, Xiulong, Liu, Zhongtian, Norrbom, Michaela, Prakash, Thazha P, O'Reilly, Daniel, Sharma, Vivek K, Damha, Masad J, Watts, Jonathan K, Rigo, Frank, Corey, David R

“…Friedreich's Ataxia (FA) is an inherited neurologic disorder caused by an expanded GAA repeat within intron 1 of the frataxin (FXN) gene that reduces…”
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Isotopic Labeling Experiments That Elucidate the Mechanism of DNA Strand Cleavage by the Hypoxia-Selective Antitumor Agent 1,2,4-Benzotriazine 1,4-Di‑N‑oxide by Shen, Xiulong, Rajapakse, Anuruddha, Gallazzi, Fabio, Junnotula, Venkatraman, Fuchs-Knotts, Tarra, Glaser, Rainer, Gates, Kent S

“…The 1,2,4-benzotriazine 1,4-dioxides are an important class of potential anticancer drugs that selectively kill the low-oxygen (hypoxic) cells found in solid…”
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Generation of DNA-Damaging Reactive Oxygen Species via the Autoxidation of Hydrogen Sulfide under Physiologically Relevant Conditions: Chemistry Relevant to Both the Genotoxic and Cell Signaling Properties of H 2 S by Hoffman, Marjorie, Rajapakse, Anuruddha, Shen, Xiulong, Gates, Kent S.

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Generation of DNA-Damaging Reactive Oxygen Species via the Autoxidation of Hydrogen Sulfide under Physiologically Relevant Conditions: Chemistry Relevant to Both the Genotoxic and Cell Signaling Properties of H sub(2)S by Hoffman, Marjorie, Rajapakse, Anuruddha, Shen, Xiulong, Gates, Kent S

“…Hydrogen sulfide (H sub(2)S) has long been known for its toxic properties; however, in recent years, evidence has emerged that this small, gaseous molecule may…”
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Hypoxia-selective Antitumor Prodrugs and Fluorescent Probes by Shen, Xiulong

“…Hypoxia-selective antitumor prodrugs utilize the unique feature of most tumors – hypoxia (low oxygen concentration), for therapeutic purpose and are widely…”
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Generation of Reactive Oxygen Species Mediated by 1‑Hydroxyphenazine, a Virulence Factor of Pseudomonas aeruginosa by Sinha, Sarmistha, Shen, Xiulong, Gallazzi, Fabio, Li, Qian, Zmijewski, Jaroslaw W, Lancaster, Jack R, Gates, Kent S

“…1-Hydroxyphenazine (1-HP) is a virulence factor produced by Pseudomonas aeruginosa. In this study, supercoiled plasmid DNA was employed as an analytical tool…”
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Generation of DNA-damaging reactive oxygen species via the autoxidation of hydrogen sulfide under physiologically relevant conditions: chemistry relevant to both the genotoxic and cell signaling properties of H(2)S by Hoffman, Marjorie, Rajapakse, Anuruddha, Shen, Xiulong, Gates, Kent S

“…Hydrogen sulfide (H(2)S) has long been known for its toxic properties; however, in recent years, evidence has emerged that this small, gaseous molecule may…”
Get full text