Search Results - "Shen, Xiu‐Da"

ASC/caspase‐1/IL‐1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury by Kamo, Naoko, Ke, Bibo, Ghaffari, Amir A., Shen, Xiu‐da, Busuttil, Ronald W., Cheng, Genhong, Kupiec‐Weglinski, Jerzy W.

“…Apoptosis‐associated speck‐like protein containing a caspase recruitment domain (ASC), an adaptor protein for inflammasome receptors, is essential for inducing…”
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T‐cell immunoglobulin and mucin domain 4 (TIM‐4) signaling in innate immune‐mediated liver ischemia‐reperfusion injury by Ji, Haofeng, Liu, Yuanxing, Zhang, Yu, Shen, Xiu‐da, Gao, Feng, Busuttil, Ronald W., Kuchroo, Vijay K., Kupiec‐Weglinski, Jerzy W.

“…Hepatic ischemia‐reperfusion injury (IRI), an innate immunity‐driven inflammation response, occurs in multiple clinical settings including liver resection,…”
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HO-1–STAT3 axis in mouse liver ischemia/reperfusion injury: Regulation of TLR4 innate responses through PI3K/PTEN signaling by Ke, Bibo, Shen, Xiu-Da, Ji, Haofeng, Kamo, Naoko, Gao, Feng, Freitas, Maria Cecilia S, Busuttil, Ronald W, Kupiec-Weglinski, Jerzy W

“…Background & Aims Signal transducer and activator of transcription 3 (STAT3), a key mediator of anti-inflammatory cytokine signaling, is essential for heme…”
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β‐catenin regulates innate and adaptive immunity in mouse liver ischemia‐reperfusion injury by Ke, Bibo, Shen, Xiu‐Da, Kamo, Naoko, Ji, Haofeng, Yue, Shi, Gao, Feng, Busuttil, Ronald W., Kupiec‐Weglinski, Jerzy W.

“…Dendritic cells (DCs) are critical mediators of immune responses that integrate signals from the innate immune system to orchestrate adaptive host immunity…”
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Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway by Zhai, Yuan, Shen, Xiu-da, O'Connell, Ryan, Gao, Feng, Lassman, Charles, Busuttil, Ronald W, Cheng, Genhong, Kupiec-Weglinski, Jerzy W

“…The triggering molecular mechanism of ischemia-reperfusion injury (IRI), which in clinical settings results in excessive and detrimental inflammatory…”
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Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: Immunomodulation by the cAMP‐PKA pathway by Ji, Haofeng, Zhang, Yu, Shen, Xiu‐da, Gao, Feng, Huang, Cynthia Y., Abad, Catalina, Busuttil, Ronald W., Waschek, James A., Kupiec‐Weglinski, Jerzy W.

“…Hepatic ischemia and reperfusion injury (IRI), an exogenous antigen‐independent local inflammation response, occurs in multiple clinical settings, including…”
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Nuclear Factor Erythroid 2–Related Factor 2 Regulates Toll-Like Receptor 4 Innate Responses in Mouse Liver Ischemia-Reperfusion Injury Through Akt-Forkhead box Protein O1 Signaling Network by Huang, Jing, Yue, Shi, Ke, Bibo, Zhu, Jianjun, Shen, Xiu-da, Zhai, Yuan, Yamamoto, Masayuki, Busuttil, Ronald W, Kupiec-Weglinski, Jerzy W

“…BACKGROUNDNuclear factor erythroid 2–related factor 2 (Nrf2), a master regulator of the antioxidant host defense, maintains the cellular redox homeostasis…”
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Biliverdin therapy protects rat livers from ischemia and reperfusion injury by Fondevila, Constantino, Shen, Xiu‐Da, Tsuchiyashi, Seiichiro, Yamashita, Kenichiro, Csizmadia, Eva, Lassman, Charles, Busuttil, Ronald W., Kupiec‐Weglinski, Jerzy W., Bach, Fritz H.

“…Heme oxygenase (HO‐1) provides a cellular defense mechanism during oxidative stress and catalyzes the rate‐limiting step in heme metabolism that produces…”
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Absence of toll‐like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model by Shen, Xiu‐Da, Ke, Bibo, Zhai, Yuan, Gao, Feng, Tsuchihashi, Sei‐Ichiro, Lassman, Charles R., Busuttil, Ronald W., Kupiec‐Weglinski, Jerzy W.

“…This study analyzes how toll‐like receptor 4 (TLR4) signaling in the donor organ affects the ischemia and reperfusion injury (IRI) sequel following liver…”
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Activation of cyclic adenosine monophosphate–dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice by Ji, Haofeng, Shen, Xiu‐da, Zhang, Yu, Gao, Feng, Huang, Cynthia Y., Chang, William W., Lee, Coney, Ke, Bibo, Busuttil, Ronald W., Kupiec‐Weglinski, Jerzy W.

“…Hepatic ischemia/reperfusion injury (IRI) occurs in multiple clinical settings, including liver transplantation. The cyclic adenosine monophosphate…”
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Toll‐Like Receptor and Heme Oxygenase‐1 Signaling in Hepatic Ischemia/Reperfusion Injury by Shen, Xiu‐Da, Ke, Bibo, Zhai, Yuan, Gao, Feng, Busuttil, Ronald W., Cheng, Genhong, Kupiec‐Weglinski, Jerzy W.

“…Ischemia/reperfusion injury (IRI) represents the major problem in clinical liver transplantation. We have shown that toll‐like receptor 4 (TLR4) signaling is…”
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Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury by Shen, Xiu‐Da, Ke, Bibo, Uchida, Yoichiro, Ji, Haofeng, Gao, Feng, Zhai, Yuan, Busuttil, Ronald W., Kupiec‐Weglinski, Jerzy W.

“…We investigated whether native macrophages overexpressing heme oxygenase 1 (HO‐1) could protect rat orthotopic liver transplant (OLT) against cold…”
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Vasoactive intestinal peptide attenuates liver ischemia/reperfusion injury in mice via the cyclic adenosine monophosphate–protein kinase a pathway by Ji, Haofeng, Zhang, Yu, Liu, Yuanxing, Shen, Xiu‐Da, Gao, Feng, Nguyen, Terry T., Busuttil, Ronald W., Waschek, James A., Kupiec‐Weglinski, Jerzy W.

“…Hepatic ischemia/reperfusion injury (IRI), an exogenous, antigen‐independent, local inflammation response, occurs in multiple clinical settings, including…”
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Adoptive Transfer of Ex Vivo HO-1 Modified Bone Marrow–derived Macrophages Prevents Liver Ischemia and Reperfusion Injury by Ke, Bibo, Shen, Xiu-Da, Gao, Feng, Ji, Haofeng, Qiao, Bo, Zhai, Yuan, Farmer, Douglas G, Busuttil, Ronald W, Kupiec-Weglinski, Jerzy W

“…Macrophages play a critical role in the pathophysiology of liver ischemia and reperfusion (IR) injury (IRI). However, macrophages that overexpress antioxidant…”
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Ex vivo exposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway by Amersi, Farin, Shen, Xiu-Da, Anselmo, Dean, Melinek, Judy, Iyer, Suhasani, Southard, Daniel J., Katori, Masamichi, Volk, Hans-Dieter, Busuttil, Ronald W., Buelow, Roland, Kupiec-Weglinski, Jerzy W.

“…A direct role of carbon monoxide (CO), an effector-signaling molecule during heme oxygenase-1 (HO-1) catalysis of heme, in the protection against hepatic…”
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Evidence for the Pivotal Role of Endogenous Toll-Like Receptor 4 Ligands in Liver Ischemia and Reperfusion Injury by YUAN ZHAI, BO QIAO, SHEN, Xiu-Da, FENG GAO, BUSUTTIL, Ronald W, GENHONG CHENG, PLATT, Jeffrey L, VOLK, Hans-Dieter, KUPIEC-WEGLINSKI, Jerzy W

“…Although toll-like receptor 4 (TLR4) activation has been demonstrated to play a key role in the induction of intrahepatic inflammation, leading to…”
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The membrane attack complex (C5b‐9) in liver cold ischemia and reperfusion injury by Fondevila, Constantino, Shen, Xiu‐Da, Tsuchihashi, Seiichiro, Uchida, Yoichiro, Freitas, Maria Cecilia, Ke, Bibo, Busuttil, Ronald W., Kupiec‐Weglinski, Jerzy W.

“…Activation of the complement cascade represents an important event during ischemia/reperfusion injury (IRI). This work was designed to investigate the role of…”
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Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury by Amersi, F, Buelow, R, Kato, H, Ke, B, Coito, A J, Shen, X D, Zhao, D, Zaky, J, Melinek, J, Lassman, C R, Kolls, J K, Alam, J, Ritter, T, Volk, H D, Farmer, D G, Ghobrial, R M, Busuttil, R W, Kupiec-Weglinski, J W

“…We examined the effects of upregulation of heme oxygenase-1 (HO-1) in steatotic rat liver models of ex vivo cold ischemia/reperfusion (I/R) injury. In the…”
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Treatment with antithymocyte globulin ameliorates intestinal ischemia and reperfusion injury in mice by Watson, Melissa J., MD, Ke, Bibo, MD, Shen, Xiu-Da, MD, Gao, Feng, MD, Busuttil, Ronald W., MD, PhD, Kupiec-Weglinski, Jerzy W., MD, PhD, Farmer, Douglas G., MD

“…Background Antithymocyte therapy, specifically antithymocyte globulin (ATG; Thymoglobulin), is increasingly being used in organ transplantation to reduce…”
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Adoptive Transfer of Heme Oxygenase-1 (HO-1)-Modified Macrophages Rescues the Nuclear Factor Erythroid 2-Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury by Huang, Jing, Shen, Xiu-Da, Yue, Shi, Zhu, Jianjun, Gao, Feng, Zhai, Yuan, Busuttil, Ronald W., Ke, Bibo, Kupiec-Weglinski, Jerzy W.

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