Search Results - "Shen, Steven S."

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability by King, Bryan, Trimarchi, Thomas, Reavie, Linsey, Xu, Luyao, Mullenders, Jasper, Ntziachristos, Panagiotis, Aranda-Orgilles, Beatriz, Perez-Garcia, Arianne, Shi, Junwei, Vakoc, Christopher, Sandy, Peter, Shen, Steven S., Ferrando, Adolfo, Aifantis, Iannis

“…Sequencing efforts led to the identification of somatic mutations that could affect the self-renewal and differentiation of cancer-initiating cells. One such…”
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PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells by Kaneko, Syuzo, Son, Jinsook, Shen, Steven S, Reinberg, Danny, Bonasio, Roberto

“…Polycomb repressive complex 2 (PRC2) acts as an epigenetic repressor by depositing repressive H3K27me3 marks, but how it is regulated and directed to specific…”
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Genome-wide and Caste-Specific DNA Methylomes of the Ants Camponotus floridanus and Harpegnathos saltator by Bonasio, Roberto, Li, Qiye, Lian, Jinmin, Mutti, Navdeep S., Jin, Lijun, Zhao, Hongmei, Zhang, Pei, Wen, Ping, Xiang, Hui, Ding, Yun, Jin, Zonghui, Shen, Steven S., Wang, Zongji, Wang, Wen, Wang, Jun, Berger, Shelley L., Liebig, Jürgen, Zhang, Guojie, Reinberg, Danny

“…Ant societies comprise individuals belonging to different castes characterized by specialized morphologies and behaviors. Because ant embryos can follow…”
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Erk1/2 Activity Promotes Chromatin Features and RNAPII Phosphorylation at Developmental Promoters in Mouse ESCs by Tee, Wee-Wei, Shen, Steven S., Oksuz, Ozgur, Narendra, Varun, Reinberg, Danny

“…Erk1/2 activation contributes to mouse ES cell pluripotency. We found a direct role of Erk1/2 in modulating chromatin features required for regulated…”
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Nascent RNA interaction keeps PRC2 activity poised and in check by Kaneko, Syuzo, Son, Jinsook, Bonasio, Roberto, Shen, Steven S, Reinberg, Danny

“…Polycomb-repressive complex 2 (PRC2) facilitates the maintenance and inheritance of chromatin domains repressive to transcription through catalysis of…”
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PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription by Beck, David B, Oda, Hisanobu, Shen, Steven S, Reinberg, Danny

“…Histone post-translational modifications impact many aspects of chromatin and nuclear function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in…”
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Immunohistochemical diagnosis of renal neoplasms by Truong, Luan D, Shen, Steven S

“…Histologic diagnosis of renal neoplasm is usually straightforward by routine light microscopy. However, immunomarkers may be essential in several contexts,…”
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Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin by Son, Jinsook, Shen, Steven S, Margueron, Raphael, Reinberg, Danny

“…Polycomb-repressive complex 2 (PRC2) comprises specific members of the Polycomb group of epigenetic modulators. PRC2 catalyzes methylation of histone H3 at Lys…”
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PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study by Ozcan, Ayhan, Shen, Steven S, Hamilton, Candice, Anjana, Kundu, Coffey, Donna, Krishnan, Bhuvaneswari, Truong, Luan D

“…PAX 8 is a transcription factor that is essential for embryonic development of the kidney, Müllerian organs, and thyroid. It may also have a role in tumor…”
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Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells by Longmire, Tyler A., Ikonomou, Laertis, Hawkins, Finn, Christodoulou, Constantina, Cao, Yuxia, Jean, J.C., Kwok, Letty W., Mou, Hongmei, Rajagopal, Jayaraj, Shen, Steven S., Dowton, Anne A., Serra, Maria, Weiss, Daniel J., Green, Michael D., Snoeck, Hans-Willem, Ramirez, Maria I., Kotton, Darrell N.

“…Two populations of Nkx2-1+ progenitors in the developing foregut endoderm give rise to the entire postnatal lung and thyroid epithelium, but little is known…”
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Clear cell papillary renal cell carcinoma is the fourth most common histologic type of renal cell carcinoma in 290 consecutive nephrectomies for renal cell carcinoma by Zhou, Haijun, MD, PhD, Zheng, Shaojiang, MD, PhD, Truong, Luan D., MD, Ro, Jae Y., MD, PhD, Ayala, Alberto G., MD, Shen, Steven S., MD, PhD

“…Summary Clear cell papillary renal cell carcinoma (CCP-RCC) has recently been recognized as a distinct subtype of renal cell carcinoma (RCC) due to its unique…”
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Principles of analytic validation of immunohistochemical assays: Guideline from the College of American Pathologists Pathology and Laboratory Quality Center by Fitzgibbons, Patrick L, Bradley, Linda A, Fatheree, Lisa A, Alsabeh, Randa, Fulton, Regan S, Goldsmith, Jeffrey D, Haas, Thomas S, Karabakhtsian, Rouzan G, Loykasek, Patti A, Marolt, Monna J, Shen, Steven S, Smith, Anthony T, Swanson, Paul E

“…Laboratories must validate all assays before they can be used to test patient specimens, but currently there are no evidence-based guidelines regarding…”
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Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium by Fiege, Jessica K, Thiede, Joshua M, Nanda, Hezkiel Arya, Matchett, William E, Moore, Patrick J, Montanari, Noe Rico, Thielen, Beth K, Daniel, Jerry, Stanley, Emma, Hunter, Ryan C, Menachery, Vineet D, Shen, Steven S, Bold, Tyler D, Langlois, Ryan A

“…The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how the…”
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Molecular Mechanisms of Malignant Transformation by Low Dose Cadmium in Normal Human Bronchial Epithelial Cells by Cartularo, Laura, Kluz, Thomas, Cohen, Lisa, Shen, Steven S, Costa, Max

“…Cadmium is a carcinogenic metal, the mechanisms of which are not fully understood. In this study, human bronchial epithelial cells were transformed with…”
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Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: evaluation of 1674 cases by tissue microarray by Turner, Bradley M, Cagle, Philip T, Sainz, Irma M, Fukuoka, Junya, Shen, Steven S, Jagirdar, Jaishree

“…Differentiation of non-small cell carcinoma into histologic types is important because of new, successful therapies that target lung adenocarcinoma (ACA)…”
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Characterization of influenza A virus induced transposons reveals a subgroup of transposons likely possessing the regulatory role as eRNAs by Shen, Steven S., Nanda, Hezkiel, Aliferis, Constantin, Langlois, Ryan A.

“…Although many studies have observed genome-wide host transposon expression alteration during viral infection, the mechanisms of induction and the impact on the…”
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Virus-induced transposable element expression up-regulation in human and mouse host cells by Macchietto, Marissa G, Langlois, Ryan A, Shen, Steven S

“…Virus-host cell interactions initiate a host cell-defensive response during virus infection. How transposable elements in the host cell respond to viral stress…”
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PAX2 and PAX8 expression in primary and metastatic renal tumors: a comprehensive comparison by Ozcan, Ayhan, de la Roza, Gustavo, Ro, Jae Y, Shen, Steven S, Truong, Luan D

“…The diagnosis of renal cell carcinoma (RCC) remains problematic, especially in the context of metastasis or small-needle biopsies. PAX2 and PAX8 transcription…”
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Immunohistochemical evaluation of novel and traditional markers associated with urothelial differentiation in a spectrum of variants of urothelial carcinoma of the urinary bladder by Paner, Gladell P., MD, Annaiah, Chandrakanth, MD, Gulmann, Christian, MD, Rao, Priya, MD, Ro, Jae Y., MD, PhD, Hansel, Donna E., MD, PhD, Shen, Steven S., MD, PhD, Lopez-Beltran, Antonio, MD, Aron, Manju, MD, Luthringer, Daniel J., MD, De Peralta-Venturina, Mariza, MD, Cho, Yong, MD, PhD, Amin, Mahul B., MD

“…Summary Data on immunohistochemical expression of novel and traditional urothelial markers in the wide range of urothelial carcinoma variants have so far been…”
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CD115+ monocytes protect microbially experienced mice against E. coli-induced sepsis by Martin, Matthew D., Skon-Hegg, Cara, Kim, Caleb Y., Xu, Julie, Kucaba, Tamara A., Swanson, Whitney, Pierson, Mark J., Williams, Jesse W., Badovinac, Vladimir P., Shen, Steven S., Ingersoll, Molly A., Griffith, Thomas S.

“…Uropathogenic E. coli (UPEC) is a primary organism responsible for urinary tract infections and a common cause of sepsis. Microbially experienced laboratory…”
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