Search Results - "Shen, Shi‐Hsiang"
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Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers
Published in Nucleic acids research (01-07-2007)“…MicroRNAs (miRNAs) are a class of noncoding small RNAs that regulate gene expression by base pairing with target mRNAs at the 3'-terminal untranslated regions…”
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High-flow nasal cannula improves respiratory impedance evaluated by impulse oscillometry in chronic obstructive pulmonary disease patients: a randomised controlled trial
Published in Scientific reports (28-04-2022)“…Non-pharmacological treatment with high-flow nasal cannula (HFNC) may play a vital role in treatment of patients with chronic obstructive pulmonary disease…”
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Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs
Published in Carcinogenesis (New York) (01-09-2008)“…MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level to lead to mRNA degradation or repressed protein…”
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Artificial stone‐associated silicosis with concurrent Cryptococcus infection
Published in Respirology case reports (01-06-2021)“…Acute silicoproteinosis is a disease that develops in weeks, and lasting for years, after massive exposure to silica dust in relatively closed spaces. It was…”
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The serine/threonine protein phosphatase SIT4 modulates yeast‐to‐hypha morphogenesis and virulence in Candida albicans
Published in Molecular microbiology (01-02-2004)“…Summary SIT4 encodes the multifunctional catalytic subunit of a type 2A‐related protein phosphatase of Saccharomyces cerevisiae and has been implicated in cell…”
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Evaluation of homogeneity and genetic stability of REOLYSIN® (pelareorep) by complete genome sequencing of reovirus after large scale production
Published in Applied microbiology and biotechnology (01-02-2014)“…REOLYSIN® (pelareorep) is a proprietary isolate of the reovirus T3D (Type 3 Dearing) strain which is currently being tested in clinical trials as an anticancer…”
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Forward and robust selection of the most potent and noncellular toxic siRNAs from RNAi libraries
Published in Nucleic acids research (01-01-2009)“…Use of highly potent small interfering RNAs (siRNAs) can substantially reduce dose-dependent cytotoxic and off-target effects. We developed a genetic forward…”
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Metformin use and post-exposure incident tuberculosis: a nationwide tuberculosis-contact cohort study in Taiwan
Published in ERJ open research (01-07-2020)“…Patients with diabetes mellitus are susceptible to active tuberculosis (TB) and latent TB infection (LTBI) [1–3]. Close contact with patients with infectious…”
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High-throughput screening of effective siRNAs from RNAi libraries delivered via bacterial invasion
Published in Nature methods (01-12-2005)“…Use of RNA interference (RNAi) as a reverse genetics tool for silencing genes in mammalian cells is achieved by in vitro transfection of small interfering RNAs…”
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PTEN Associates with the Vault Particles in HeLa Cells
Published in The Journal of biological chemistry (25-10-2002)“…PTEN is a tumor suppressor that primarily dephosphorylates phosphatidylinositol 3,4,5-trisphosphate to down-regulate the phosphoinositide 3-kinase/Akt…”
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Disruption of a gene encoding glycerol 3-phosphatase from Candida albicans impairs intracellular glycerol accumulation-mediated salt-tolerance
Published in FEMS microbiology letters (01-04-2005)“…Intracellular glycerol accumulation is critical for Candida albicans to maintain osmolarity, and therefore defects in glycerol homeostasis can have severe…”
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Caspase-8-mediated Intracellular Acidification Precedes Mitochondrial Dysfunction in Somatostatin-induced Apoptosis
Published in The Journal of biological chemistry (31-03-2000)“…Activation of initiator and effector caspases, mitochondrial changes involving a reduction in its membrane potential and release of cytochrome c (cyt c) into…”
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Declining trend in incidence of tuberculosis in adolescents and young adults in Taiwan
Published in The European respiratory journal (01-05-2019)Get full text
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Expression of CaPTC7 is developmentally regulated during serum-induced morphogenesis in the human fungal pathogen Candida albicans
Published in Canadian journal of microbiology (01-02-2007)“…Type 2C protein phosphatases (PP2C) represent a diversified protein phosphatase family and play various roles in cells. We previously identified and…”
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Regulation of Acidification and Apoptosis by SHP-1 and Bcl-2
Published in The Journal of biological chemistry (08-10-1999)“…Recruitment of the SH2 domain containing cytoplasmic protein-tyrosine phosphatase SHP-1 to the membrane by somatostatin (SST) is an early event in its…”
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Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos
Published in Nucleic acids research (01-01-2007)“…MicroRNAs (miRNAs) are non-coding small RNAs of ~22 nt that regulate the gene expression by base pairing with target mRNAs, leading to mRNA cleavage or…”
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SHP‐1 dephosphorylates 3BP2 and potentially downregulates 3BP2‐mediated T cell antigen receptor signaling
Published in The FEBS journal (01-05-2006)“…Src homology 2 (SH2) domain‐containing protein tyrosine phosphatase‐1 (SHP‐1) is a critical inhibitory regulator in T cell‐receptor (TCR) signaling. However,…”
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Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma
Published in Carcinogenesis (New York) (01-02-2004)“…The phosphoinositide 3-kinase (PI 3-kinase) signaling pathway has been shown to play a pivotal role in intracellular signal transduction pathways involved in…”
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A Widely Expressed Human Protein-Tyrosine Phosphatase Containing src Homology 2 Domains
Published in Proceedings of the National Academy of Sciences - PNAS (15-03-1993)“…A cDNA encoding a nontransmembrane protein-tyrosine phosphatase (PTP; EC 3.1.3.48), termed PTP2C, was isolated from a human umbilical cord cDNA library. The…”
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