Search Results - "Shen, Qingya"

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir by Yin, Wanchao, Mao, Chunyou, Luan, Xiaodong, Shen, Dan-Dan, Shen, Qingya, Su, Haixia, Wang, Xiaoxi, Zhou, Fulai, Zhao, Wenfeng, Gao, Minqi, Chang, Shenghai, Xie, Yuan-Chao, Tian, Guanghui, Jiang, He-Wei, Tao, Sheng-Ce, Shen, Jingshan, Jiang, Yi, Jiang, Hualiang, Xu, Yechun, Zhang, Shuyang, Zhang, Yan, Xu, H Eric

“…The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis…”
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Cryo-EM structures of inactive and active GABAB receptor by Mao, Chunyou, Shen, Cangsong, Li, Chuntao, Shen, Dan-Dan, Xu, Chanjuan, Zhang, Shenglan, Zhou, Rui, Shen, Qingya, Chen, Li-Nan, Jiang, Zhinong, Liu, Jianfeng, Zhang, Yan

“…Metabotropic GABA B G protein-coupled receptor functions as a mandatory heterodimer of GB1 and GB2 subunits and mediates inhibitory neurotransmission in the…”
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Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex by Ping, Yu-Qi, Mao, Chunyou, Xiao, Peng, Zhao, Ru-Jia, Jiang, Yi, Yang, Zhao, An, Wen-Tao, Shen, Dan-Dan, Yang, Fan, Zhang, Huibing, Qu, Changxiu, Shen, Qingya, Tian, Caiping, Li, Zi-jian, Li, Shaolong, Wang, Guang-Yu, Tao, Xiaona, Wen, Xin, Zhong, Ya-Ni, Yang, Jing, Yi, Fan, Yu, Xiao, Xu, H. Eric, Zhang, Yan, Sun, Jin-Peng

“…Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited knowledge of their ligand regulation or structure is available 1 – 3 …”
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Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1 by Shao, Zhehua, Shen, Qingya, Yao, Bingpeng, Mao, Chunyou, Chen, Li-Nan, Zhang, Huibing, Shen, Dan-Dan, Zhang, Chao, Li, Weijie, Du, Xufei, Li, Fei, Ma, Honglei, Chen, Zhi-Hua, Xu, H. Eric, Ying, Songmin, Zhang, Yan, Shen, Huahao

“…Biased signaling of G protein-coupled receptors describes an ability of different ligands that preferentially activate an alternative downstream signaling…”
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Structural basis of GPBAR activation and bile acid recognition by Yang, Fan, Mao, Chunyou, Guo, Lulu, Lin, Jingyu, Ming, Qianqian, Xiao, Peng, Wu, Xiang, Shen, Qingya, Guo, Shimeng, Shen, Dan-Dan, Lu, Ruirui, Zhang, Linqi, Huang, Shenming, Ping, Yuqi, Zhang, Chenlu, Ma, Cheng, Zhang, Kai, Liang, Xiaoying, Shen, Yuemao, Nan, Fajun, Yi, Fan, Luca, Vincent C., Zhou, Jiuyao, Jiang, Changtao, Sun, Jin-Peng, Xie, Xin, Yu, Xiao, Zhang, Yan

“…The G-protein-coupled bile acid receptor (GPBAR) conveys the cross-membrane signalling of a vast variety of bile acids and is a signalling hub in the…”
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GHCL: Gaussian heuristic curriculum learning for Brain CT report generation by Shen, Qingya, Shi, Yanzhao, Zhang, Xiaodan, Ji, Junzhong, Liu, Ying, Xu, Huimin

“…Brain computed tomography (CT) report generation, which aims at generating accurate and descriptive reports for Brain CT imaging, has gained growing attention…”
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Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors by Ma, Shanshan, Shen, Qingya, Zhao, Li-Hua, Mao, Chunyou, Zhou, X. Edward, Shen, Dan-Dan, de Waal, Parker W., Bi, Peng, Li, Chuntao, Jiang, Yi, Wang, Ming-Wei, Sexton, Patrick M., Wootten, Denise, Melcher, Karsten, Zhang, Yan, Xu, H. Eric

“…Corticotropin-releasing factor (CRF) and the three related peptides urocortins 1–3 (UCN1–UCN3) are endocrine hormones that control the stress responses by…”
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Structural insights into ligand recognition and activation of the melanocortin-4 receptor by Zhang, Huibing, Chen, Li-Nan, Yang, Dehua, Mao, Chunyou, Shen, Qingya, Feng, Wenbo, Shen, Dan-Dan, Dai, Antao, Xie, Shanshan, Zhou, Yan, Qin, Jiao, Sun, Jin-Peng, Scharf, Daniel H., Hou, Tingjun, Zhou, Tianhua, Wang, Ming-Wei, Zhang, Yan

“…Melanocortin-4 receptor (MC4R) plays a central role in the regulation of energy homeostasis. Its high sequence similarity to other MC receptor family members,…”
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Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation by Zhai, Xiuwen, Mao, Chunyou, Shen, Qingya, Zang, Shaokun, Shen, Dan-Dan, Zhang, Huibing, Chen, Zhaohong, Wang, Gang, Zhang, Changming, Zhang, Yan, Liu, Zhihong

“…The parathyroid hormone type 1 receptor (PTH1R), a class B1 G protein-coupled receptor, plays critical roles in bone turnover and Ca 2+ homeostasis…”
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Orthosteric and allosteric modulation of human HCAR2 signaling complex by Mao, Chunyou, Gao, Mengru, Zang, Shao-Kun, Zhu, Yanqing, Shen, Dan-Dan, Chen, Li-Nan, Yang, Liu, Wang, Zhiwei, Zhang, Huibing, Wang, Wei-Wei, Shen, Qingya, Lu, Yanhui, Ma, Xin, Zhang, Yan

“…Hydroxycarboxylic acids are crucial metabolic intermediates involved in various physiological and pathological processes, some of which are recognized by…”
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Author Correction: Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation by Zhang, Xiaoying, Shen, Qingya, Lei, Zhen, Wang, Qianyi, Zheng, Jimin, Jia, Zongchao

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation by Zhang, Xiaoying, Shen, Qingya, Lei, Zhen, Wang, Qianyi, Zheng, Jimin, Jia, Zongchao

“…A unique bifunctional enzyme, isocitrate dehydrogenase kinase/phosphatase (AceK) regulates isocitrate dehydrogenase (IDH) by phosphorylation and…”
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Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3 by Shao, Zhehua, Tan, Yangxia, Shen, Qingya, Hou, Li, Yao, Bingpeng, Qin, Jiao, Xu, Peiyu, Mao, Chunyou, Chen, Li-Nan, Zhang, Huibing, Shen, Dan-Dan, Zhang, Chao, Li, Weijie, Du, Xufei, Li, Fei, Chen, Zhi-Hua, Jiang, Yi, Xu, H. Eric, Ying, Songmin, Ma, Honglei, Zhang, Yan, Shen, Huahao

“…Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present…”
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A new method to investigate the catalytic mechanism of YhdE pyrophosphatase by using a pyrophosphate fluorescence probe by Shen, Qingya, Tan, Hongwei, Xing, Guo-wen, Zheng, Jimin, Jia, Zongchao

“…YhdE is a Maf (multicopy associated filamentation) proteins from Escherichia coli which exhibits pyrophosphatase activity towards selected nucleotides,…”
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Characterization of C-terminal structure of MinC and its implication in evolution of bacterial cell division by Yang, Shaoyuan, Shen, Qingya, Wang, Shu, Song, Chen, Lei, Zhen, Han, Shengnan, Zhang, Xiaoying, Zheng, Jimin, Jia, Zongchao

“…Proper cell division at the mid-site of Gram-negative bacteria reflects stringent regulation by the min system (MinC, MinD and MinE). Herein we report crystal…”
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Molecular Determinant Underlying Selective Coupling of Primary G‐Protein by Class A GPCRs by Shen, Qingya, Tang, Xinyan, Wen, Xin, Cheng, Shizhuo, Xiao, Peng, Zang, Shao‐Kun, Shen, Dan‐Dan, Jiang, Lei, Zheng, Yanrong, Zhang, Huibing, Xu, Haomang, Mao, Chunyou, Zhang, Min, Hu, Weiwei, Sun, Jin‐Peng, Zhang, Yan, Chen, Zhong

“…G‐protein‐coupled receptors (GPCRs) transmit downstream signals predominantly via G‐protein pathways. However, the conformational basis of selective coupling…”
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The phosphatase mechanism of bifunctional kinase/phosphatase AceK by Wang, Shu, Shen, Qingya, Chen, Guangju, Zheng, Jimin, Tan, Hongwei, Jia, Zongchao

“…We have revealed that bifunctional AceK kinase/phosphatase utilizes a stepwise addition-elimination mechanism in its dephosphorylation reaction. This work…”
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Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5 by Shen, Qingya, Qiu, Zhiyu, Wu, Wenping, Zheng, Jimin, Jia, Zongchao

“…Phosphoenolpyruvate carboxykinase (PEPCK1) is ubiquitinated by E3 ubiquitin ligase UBR5, which was thought to be facilitated by the acetylation of Lys70, Lys71…”
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Molecular basis for the activation of thyrotropin-releasing hormone receptor by Ji, Su-Yu, Dong, Ying-Jun, Chen, Li-Nan, Zang, Shao-Kun, Wang, Jiawei, Shen, Dan-Dan, Guo, Jia, Qin, Jiao, Zhang, Huibing, Wang, Wei-Wei, Shen, Qingya, Zhang, Yan, Song, Zhangfa, Mao, Chunyou

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The structure of the MICU1‐MICU2 complex unveils the regulation of the mitochondrial calcium uniporter by Wu, Wenping, Shen, Qingya, Zhang, Ruiling, Qiu, Zhiyu, Wang, Youjun, Zheng, Jimin, Jia, Zongchao

“…The MICU1‐MICU2 heterodimer regulates the mitochondrial calcium uniporter (MCU) and mitochondrial calcium uptake. Herein, we present two crystal structures of…”
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