Search Results - "Shen, Mingqiang"
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1
Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease–associated thrombosis in mice
Published in Blood (11-05-2017)“…Thrombosis is a common complication of chronic kidney disease (CKD), but the causes and mechanisms of CKD-associated thrombosis are not well clarified. Here,…”
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2
Gut microbial dysbiosis may predict diarrhea and fatigue in patients undergoing pelvic cancer radiotherapy: a pilot study
Published in PloS one (08-05-2015)“…Fatigue and diarrhea are the most frequent adverse effects of pelvic radiotherapy, while their etiologies are largely unknown. The aim of this study is to…”
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3
SRC-3 is involved in maintaining hematopoietic stem cell quiescence by regulation of mitochondrial metabolism in mice
Published in Blood (30-08-2018)“…Quiescence maintenance is an important property of hematopoietic stem cells (HSCs), whereas the regulatory factors and underlying mechanisms involved in HSC…”
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4
CD63 acts as a functional marker in maintaining hematopoietic stem cell quiescence through supporting TGFβ signaling in mice
Published in Cell death and differentiation (01-01-2022)“…Hematopoietic stem cell (HSC) fate is tightly controlled by various regulators, whereas the underlying mechanism has not been fully uncovered due to the high…”
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5
MicroRNA-21 maintains hematopoietic stem cell homeostasis through sustaining the NF-κB signaling pathway in mice
Published in Haematologica (Roma) (01-02-2021)“…Long-term hematopoietic output is dependent on hematopoietic stem cell (HSC) homeostasis which is maintained by a complex molecular network. Among these,…”
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6
CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21
Published in Leukemia (01-04-2022)“…The cell cycle progression of hematopoietic stem cells (HSCs) and acute myeloid leukemia (AML) cells is precisely controlled by multiple regulatory factors…”
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Sympathetic stimulation facilitates thrombopoiesis by promoting megakaryocyte adhesion, migration, and proplatelet formation
Published in Blood (25-02-2016)“…The effect of sympathetic stimulation on thrombopoiesis is not well understood. Here, we demonstrate that both continual noise and exhaustive exercise elevate…”
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8
Brain diffusion tensor imaging reveals altered connections and networks in epilepsy patients
Published in Frontiers in human neuroscience (22-03-2023)“…Accumulating evidence shows that epilepsy is a disease caused by brain network dysfunction. This study explored changes in brain network structure in epilepsy…”
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9
Megakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury
Published in Cell communication and signaling (27-05-2024)“…Hematopoietic stem cell (HSC) regeneration underlies hematopoietic recovery from myelosuppression, which is a life-threatening side effect of cytotoxicity. HSC…”
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10
Study of brain network alternations in non-lesional epilepsy patients by BOLD-fMRI
Published in Frontiers in neuroscience (18-01-2023)“…To investigate the changes of brain network in epilepsy patients without intracranial lesions under resting conditions. Twenty-six non-lesional epileptic…”
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11
Altered brain networks and connections in chronic heart failure patients complicated with cognitive impairment
Published in Frontiers in aging neuroscience (14-04-2023)“…Accumulating evidence shows that cognitive impairment (CI) in chronic heart failure (CHF) patients is related to brain network dysfunction. This study…”
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12
Reduction Impairs the Antibacterial Activity but Benefits the LPS Neutralization Ability of Human Enteric Defensin 5
Published in Scientific reports (10-03-2016)“…Oxidized human defensin 5 (HD5 OX ), a Paneth cell-secreted antibacterial peptide with three characteristic disulfide bonds, protects the host from invasion by…”
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13
Enhancement of Antiviral Activity of Human Alpha-Defensin 5 against Herpes Simplex Virus 2 by Arginine Mutagenesis at Adaptive Evolution Sites
Published in Journal of Virology (01-03-2013)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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14
Effect of radiation-induced endothelial cell injury on platelet regeneration by megakaryocytes
Published in Journal of radiation research (01-07-2017)“…Abstract Thrombocytopenia is an important cause of hemorrhage and death after radiation injury, but the pathogenesis of radiation-induced thrombocytopenia has…”
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15
Dopamine induces platelet production from megakaryocytes via oxidative stress-mediated signaling pathways
Published in Platelets (Edinburgh) (03-10-2018)“…Dopamine (DA), a catecholamine neurotransmitter, is known to for its diverse roles on hematopoiesis, yet its function in thrombopoiesis remains poorly…”
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16
High level expression and purification of bioactive human α-defensin 5 mature peptide in Pichia pastoris
Published in Applied microbiology and biotechnology (01-10-2009)“…Human α-defensin 5 (HD₅), a small cysteine-rich peptide expressed predominantly in small intestine and female reproductive tissues, plays an important role in…”
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High efficiency preparation of bioactive human α-defensin 6 in Escherichia coli Origami(DE3)pLysS by soluble fusion expression
Published in Applied microbiology and biotechnology (01-08-2010)“…Human α-defensin 6 (HD₆), a small cysteine-rich cationic peptide specially expressed in epithelial cells of digestive tract, may play a crucial role in mucosal…”
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Development of a sandwich enzyme-linked immunosorbent assay for dTMP-GH fusion protein by rational immunogen selection
Published in AMB Express (17-07-2017)“…dTMP-GH is a chimeric protein containing a tandem dimer of thrombopoietin mimetic peptide (dTMP) fused to human growth hormone (hGH) prepared previously by our…”
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19
Subcutaneous administration of rhIGF-I post irradiation exposure enhances hematopoietic recovery and survival in BALB/c mice
Published in Journal of radiation research (01-07-2012)“…It is unclear how to effectively mitigate against irradiation injury. In this study, we studied the capacity of recombinant human insulin-like growth factor-I…”
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Transcription factor Nkx2-3 maintains the self-renewal of hematopoietic stem cells by regulating mitophagy
Published in Leukemia (01-06-2023)“…Hematopoietic stem cells (HSCs) reside at the top of the hematopoietic hierarchy, exhibiting a unique capacity to self-renew and differentiate into all blood…”
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