Search Results - "Shen, Meng‐Ru"

The distinct role of STIM1 and STIM2 in the regulation of store‐operated Ca2+ entry and cellular function by Chen, Yih‐Fung, Chen, Li‐Hsien, Shen, Meng‐Ru

“…Stromal interaction molecules STIM1 and STIM2 are endoplasmic reticulum (ER) Ca2+ sensors that initiate store‐operated Ca 2+ entry (SOCE). The roles of…”
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Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis by Chen, Yih-Fung, Chiu, Wen-Tai, Chen, Ying-Ting, Lin, Pey-Yun, Huang, Huey-Jy, Chou, Cheng-Yang, Chang, Hsien-Chang, Tang, Ming-Jer, Shen, Meng-Ru

“…Store-operated Ca2+ entry (SOCE) is the principal Ca2+ entry mechanism in nonexcitable cells. Stromal-interaction molecule 1 (STIM1) is an endoplasmic…”
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Remodeling of calcium signaling in tumor progression by Chen, Yih-Fung, Chen, Ying-Ting, Chiu, Wen-Tai, Shen, Meng-Ru

“…Intracellular Ca2+ is one of the crucial signalings that modulate various cellular functions. The dysregulation of Ca2+ homeostasis has been suggested as an…”
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Epithelial-Mesenchymal Transition in Cervical Cancer: Correlation with Tumor Progression, Epidermal Growth Factor Receptor Overexpression, and Snail Up-Regulation by LEE, Mei-Yi, CHOU, Cheng-Yang, TANG, Ming-Jer, SHEN, Meng-Ru

“…Purpose: Acquisition of epithelial-mesenchymal transition (EMT) by primary carcinoma cells is associated with disrupted epithelial integrity, local invasion,…”
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Mutation of the PTCH1 gene predicts recurrence of breast cancer by Wang, Chih-Yang, Chang, Yung-Chieh, Kuo, Yao-Lung, Lee, Kuo-Ting, Chen, Pai-Sheng, Cheung, Chun Hei Antonio, Chang, Chih-Peng, Phan, Nam Nhut, Shen, Meng-Ru, Hsu, Hui-Ping

“…Breast cancer is the most common cancer in women, and some patients develop recurrence after standard therapy. Effective predictors are urgently needed to…”
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The Important Role of Ion Transport System in Cervical Cancer by Chen, Yih-Fung, Shen, Meng-Ru

“…Cervical cancer is a significant gynecological cancer and causes cancer-related deaths worldwide. Human papillomavirus (HPV) is implicated in the etiology of…”
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Mechanical phenotype of cancer cells: cell softening and loss of stiffness sensing by Lin, Hsi-Hui, Lin, Hsiu-Kuan, Lin, I-Hsuan, Chiou, Yu-Wei, Chen, Horn-Wei, Liu, Ching-Yi, Harn, Hans I-Chen, Chiu, Wen-Tai, Wang, Yang-Kao, Shen, Meng-Ru, Tang, Ming-Jer

“…The stiffness sensing ability is required to respond to the stiffness of the matrix. Here we determined whether normal cells and cancer cells display distinct…”
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A novel deep learning-based algorithm combining histopathological features with tissue areas to predict colorectal cancer survival from whole-slide images by Li, Yan-Jun, Chou, Hsin-Hung, Lin, Peng-Chan, Shen, Meng-Ru, Hsieh, Sun-Yuan

“…Abstract Background Many methodologies for selecting histopathological images, such as sample image patches or segment histology from regions of interest…”
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Precise uncertain significance prediction using latent space matrix factorization models: genomics variant and heterogeneous clinical data-driven approaches by Abdollahi, Sina, Lin, Peng-Chan, Shen, Meng-Ru, Chiang, Jung-Hsien

“…Abstract Several studies to date have proposed different types of interpreters for measuring the degree of pathogenicity of variants. However, in predicting…”
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Slice-Fusion: Reducing False Positives in Liver Tumor Detection for Mask R-CNN by Tu, Deng-Yao, Lin, Peng-Chan, Chou, Hsin-Hung, Shen, Meng-Ru, Hsieh, Sun-Yuan

“…Automatic liver tumor detection from computed tomography (CT) makes clinical examinations more accurate. However, deep learning-based detection algorithms are…”
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Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition by Huang, Yi-Ting, Hsu, Ya-Ting, Wu, Pei-Ying, Yeh, Yu-Min, Lin, Peng-Chan, Hsu, Keng-Fu, Shen, Meng-Ru

“…Cingulin (CGN) is a pivotal cytoskeletal adaptor protein located at tight junctions. This study investigates the link between CGN mutation and increased cancer…”
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Super-Resolution Microscopy Reveals That Stromal Interaction Molecule 1 Trafficking Depends on Microtubule Dynamics by Huang, Yi-Ting, Hsu, Ya-Ting, Chen, Yih-Fung, Shen, Meng-Ru

“…Store-operated Ca 2+ entry (SOCE) is an essential pathway for Ca 2+ signaling, and regulates various vital cellular functions. It is triggered by the…”
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CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c.1085 Genotypes by Yeh, Yu-Min, Lin, Peng-Chan, Su, Wu-Chou, Shen, Meng-Ru

“…Colony-stimulating factor 1 receptor (CSF-1R) acts as the receptor for colony stimulating factor 1, a cytokine that controls the production, differentiation,…”
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Germline susceptibility variants impact clinical outcome and therapeutic strategies for stage III colorectal cancer by Lin, Peng-Chan, Yeh, Yu-Min, Wu, Pei-Ying, Hsu, Keng-Fu, Chang, Jang-Yang, Shen, Meng-Ru

“…Although somatic mutations are the main cause of cancer, underlying germline alterations may affect cancer outcome. There is little information on…”
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Sequential and co-occurring DNA damage response genetic mutations impact survival in stage III colorectal cancer patients receiving adjuvant oxaliplatin-based chemotherapy by Lin, Peng-Chan, Yeh, Yu-Min, Chan, Ren-Hao, Lin, Bo-Wen, Chen, Po-Chuan, Pan, Chien-Chang, Shen, Meng-Ru

“…Certain sequences of genomic mutations can lead to cancer formation and affect treatment outcomes and drug resistance. We constructed a cancer evolutionary…”
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PD-L1 Expression in High-Risk Early-Stage Colorectal Cancer—Its Clinical and Biological Significance in Immune Microenvironment by Chung, Bing-Syuan, Liao, I-Chuang, Lin, Peng-Chan, Wu, Shang-Yin, Kang, Jui-Wen, Lin, Bo-Wen, Chen, Po-Chuan, Chan, Ren-Hao, Lee, Chung-Ta, Shen, Meng-Ru, Chen, Shang-Hung, Yeh, Yu-Min

“…Programmed death-ligand 1 (PD-L1) is an immune checkpoint molecule that can regulate immune responses in the tumor microenvironment (TME); however, the…”
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Pathogenicity Prediction of Single Amino Acid Variants With Machine Learning Model Based on Protein Structural Energies by Wu, Tzu-Hsuan, Lin, Peng-Chan, Chou, Hsin-Hung, Shen, Meng-Ru, Hsieh, Sun-Yuan

“…The most popular tools for predicting pathogenicity of single amino acid variants (SAVs) were developed based on sequence-based techniques. SAVs may change…”
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Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy by Chen, Yi-Fan, Chen, Li-Hsien, Yeh, Yu-Min, Wu, Pei-Ying, Chen, Yih-Fung, Chang, Lian-Yun, Chang, Jang-Yang, Shen, Meng-Ru

“…Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment. No medication has been shown to be effective in the treatment of…”
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Germline MLH1 and MSH6 mutations from two Lynch syndrome families identified in a patient with early-onset of endometrial cancer: A case report by Huang, Yi-Ching, Lin, Peng-Chan, Wu, Pei-Ying, Chen, Nai-Syuan, Shen, Meng-Ru, Yeh, Yu-Min, Cheng, Ya-Min

“…•Patients harboring different MMR gene mutations from two Lynch syndrome families are rare.•The diagnosis of Lynch syndrome-related endometrial cancer at the…”
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The Value of Artificial Intelligence-Assisted Imaging in Identifying Diagnostic Markers of Sarcopenia in Patients with Cancer by Huang, Ying-Tzu, Tsai, Yi-Shan, Lin, Peng-Chan, Yeh, Yu-Min, Hsu, Ya-Ting, Wu, Pei-Ying, Shen, Meng-Ru

“…Sarcopenia is defined as the loss of skeletal muscle mass and muscle function. It is common in patients with malignancies and often associated with adverse…”
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