Regulation of c-fos expression by the dopamine D1-D2 receptor heteromer

Highlights • Dopamine D1-D2 heteromer activation induces c-fos in the nucleus accumbens. • A selective antagonist of the D1-D2 heteromer is the TAT-D1 peptide. • TAT-D1 increases c-fos in cortical subregions such as prefrontal cortex. • TAT-D1 increases c-fos expression in lateral habenula and thala...

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Bibliographic Details
Published in:	Neuroscience Vol. 285; pp. 194 - 203
Main Authors:	Perreault, M.L, Shen, M.Y.F, Fan, T, George, S.R
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 29-01-2015
Subjects:	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - analogs & derivatives 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology Animals Brain - drug effects Brain - metabolism c-fos Cell Count cortex Dimerization Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology dopamine D1-D2 heteromer Immunohistochemistry lateral habenula Male Neurology Neurons - drug effects Neurons - metabolism nucleus accumbens Proto-Oncogene Proteins c-fos - metabolism Rats, Sprague-Dawley Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism anterior olfactory nucleus medial prefrontal cortex prelimbic cortex infralimbic cortex prefrontal cortex piriform cortex dopamine D1-D2 heteromer PiC PVP PFC paraventricular thalamic nucleus OFC medial habenula GSK-3β NAc DV TBS-T Tris-buffered saline-Tween analysis of variance ANOVA glycogen synthase kinase-3β orbitofrontal cortex brain-derived neurotrophic factor lateral habenula ML cortex AOP IL BDNF dorsoventral caudate putamen MHb LHb TAT-Sc c-fos nucleus accumbens CP AP mPFC TAT-scrambled peptide control PL mediolateral anterior–posterior
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Summary:	Highlights • Dopamine D1-D2 heteromer activation induces c-fos in the nucleus accumbens. • A selective antagonist of the D1-D2 heteromer is the TAT-D1 peptide. • TAT-D1 increases c-fos in cortical subregions such as prefrontal cortex. • TAT-D1 increases c-fos expression in lateral habenula and thalamus.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Authors contributed equally to the manuscript.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.11.017