Mechanism insights into the pleiotropic effects of nobiletin as a potential therapeutic agent on non-alcoholic fatty liver disease (NAFLD)

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and is emerging as one of the fastest-growing causes of liver-related deaths worldwide. It is necessary to find strategies to effectively prevent and treat NAFLD, as no definitive drug has been approved. Nobiletin (NO...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 173; p. 116322
Main Authors:	Ran, Qiqi, Gan, Qianrong, Zhu, Ye, Song, Li, Shen, Longyu, Duan, Xinyi, Zhu, Xinyun, Huang, Wei
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-04-2024 Elsevier
Subjects:	Anti-inflammatory Anti-oxidation Drugs, Chinese Herbal - pharmacology Flavones - pharmacology Flavones - therapeutic use Humans Insulin resistance Lipid metabolism Liver Nobiletin Non-alcoholic fatty liver disease Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - etiology FFA C/EBPβ DNL DG CPT JNK HFD FBG Anti-oxidation TRL PPAR PI3K VLDL HSC Lipid metabolism NAFL SREBP IBMX HCD HCC SCD-1 IκBα MetS 3’-DMN 3 ROR ROS CAT NF AMPK Anti-inflammatory NAFLD GSH-PX PGC1α COX-2 LPL WAT 5-DMN CREB Nrf2 HFHC STAT5 4’-DMN ACC AP2 SOD INOS NASH TC MCD PA Nobiletin DEX FAS Insulin resistance Non-alcoholic fatty liver disease MCU
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Summary:	Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and is emerging as one of the fastest-growing causes of liver-related deaths worldwide. It is necessary to find strategies to effectively prevent and treat NAFLD, as no definitive drug has been approved. Nobiletin (NOB) is the critical active ingredient of Chinese herbal medicines such as Citrus aurantium and Citri Reticulatae Pericarpium, which have anti-inflammatory, antioxidant, lipid regulating, and insulin resistance regulating effects. Numerous studies have demonstrated that NOB can prevent and treat the onset and progression of NAFLD. In this review, the mechanisms of NOB for treating NAFLD have been summarized, hoping to provide a basis for subsequent studies of NOB and to provide a research ground for the development of therapeutic drugs for NAFLD.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2024.116322