Search Results - "Shen, Juwen"

Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework by Song, Ping, Shen, Juwen, Ye, Dekai, Dong, Baijun, Wang, Fei, Pei, Hao, Wang, Jianbang, Shi, Jiye, Wang, Lihua, Xue, Wei, Huang, Yiran, Huang, Gang, Zuo, Xiaolei, Fan, Chunhai

“…Protein-protein interactions are spatially regulated in living cells to realize high reaction efficiency, as seen in naturally existing electron-transfer…”
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Recent Development of Sandwich Assay Based on the Nanobiotechnologies for Proteins, Nucleic Acids, Small Molecules, and Ions by Shen, Juwen, Li, Yuebin, Gu, Haoshuang, Xia, Fan, Zuo, Xiaolei

“…Shen et al discuss the recent development of sandwich assay based on the nanobiotechnolgies for proteins, nucleic acids, small molecules and ions. Topics…”
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Predicting protein-protein interactions based only on sequences information by Shen, Juwen, Zhang, Jian, Luo, Xiaomin, Zhu, Weiliang, Yu, Kunqian, Chen, Kaixian, Li, Yixue, Jiang, Hualiang

“…Protein-protein interactions (PPIs) are central to most biological processes. Although efforts have been devoted to the development of methodology for…”
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Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects by Zhang, Qiansen, Ren, Yimin, Mo, Yiqing, Guo, Peipei, Liao, Ping, Luo, Yuncheng, Mu, Jie, Chen, Zhuo, Zhang, Yang, Li, Ya, Yang, Linghui, Liao, Daqing, Fu, Jie, Shen, Juwen, Huang, Wei, Xu, Xuewen, Guo, Yanyan, Mei, Lianghe, Zuo, Yunxia, Liu, Jin, Yang, Huaiyu, Jiang, Ruotian

“…Both opioids and nonsteroidal anti-inflammatory drugs (NSAIDS) produce deleterious side effects and fail to provide sustained relief in patients with chronic…”
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General Pharmacological Activation Mechanism of K+ Channels Bypassing Channel Gates by Liu, Shijie, Guo, Peipei, Wang, Kun, Zhang, Shaoying, Li, Ya, Shen, Juwen, Mei, Lianghe, Ye, Yangliang, Zhang, Qiansen, Yang, Huaiyu

“…Under the known pharmacological activation mechanisms, activators allosterically or directly open potassium channel gates. However, herein, molecular dynamics…”
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Author Correction: Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework by Song, Ping, Shen, Juwen, Ye, Dekai, Dong, Baijun, Wang, Fei, Pei, Hao, Wang, Jianbang, Shi, Jiye, Wang, Lihua, Xue, Wei, Huang, Yiran, Huang, Gang, Zuo, Xiaolei, Fan, Chunhai

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DNA Tetrahedral Nanostructure-Based Electrochemical miRNA Biosensor for Simultaneous Detection of Multiple miRNAs in Pancreatic Carcinoma by Zeng, Dongdong, Wang, Zehua, Meng, Zhiqiang, Wang, Peng, San, Lili, Wang, Wei, Aldalbahi, Ali, Li, Li, Shen, Juwen, Mi, Xianqiang

“…Specific and sensitive biomarker detection is essential to early cancer diagnosis. In this study, we demonstrate an ultrasensitive electrochemical biosensor…”
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DNA-framework-based multidimensional molecular classifiers for cancer diagnosis by Yin, Fangfei, Zhao, Haipei, Lu, Shasha, Shen, Juwen, Li, Min, Mao, Xiuhai, Li, Fan, Shi, Jiye, Li, Jiang, Dong, Baijun, Xue, Wei, Zuo, Xiaolei, Yang, Xiurong, Fan, Chunhai

“…A molecular classification of diseases that accurately reflects clinical behaviour lays the foundation of precision medicine. The development of in silico…”
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Valency‐Controlled Framework Nucleic Acid Signal Amplifiers by Liu, Qi, Ge, Zhilei, Mao, Xiuhai, Zhou, Guobao, Zuo, Xiaolei, Shen, Juwen, Shi, Jiye, Li, Jiang, Wang, Lihua, Chen, Xiaoqing, Fan, Chunhai

“…Weak ligand–receptor recognition events are often amplified by recruiting multiple regulatory biomolecules to the action site in biological systems. However,…”
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PolyA-Mediated DNA Assembly on Gold Nanoparticles for Thermodynamically Favorable and Rapid Hybridization Analysis by Zhu, Dan, Song, Ping, Shen, Juwen, Su, Shao, Chao, Jie, Aldalbahi, Ali, Zhou, Ziang, Song, Shiping, Fan, Chunhai, Zuo, Xiaolei, Tian, Yang, Wang, Lianhui, Pei, Hao

“…Understanding the behavior of biomolecules on nanointerface is critical in bioanalysis, which is great challenge due to the instability and the difficulty to…”
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Dynamic Modulation of DNA Hybridization Using Allosteric DNA Tetrahedral Nanostructures by Song, Ping, Li, Min, Shen, Juwen, Pei, Hao, Chao, Jie, Su, Shao, Aldalbahi, Ali, Wang, Lihua, Shi, Jiye, Song, Shiping, Wang, Lianhui, Fan, Chunhai, Zuo, Xiaolei

“…The fixed dynamic range of traditional biosensors limits their utility in several real applications. For example, viral load monitoring requires the dynamic…”
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A small-molecule activation mechanism that directly opens the KCNQ2 channel by Zhang, Shaoying, Ma, Demin, Wang, Kun, Li, Ya, Yang, Zhenni, Li, Xiaoxiao, Li, Junnan, He, Jiangnan, Mei, Lianghe, Ye, Yangliang, Chen, Zongsheng, Shen, Juwen, Hou, Panpan, Guo, Jiangtao, Zhang, Qiansen, Yang, Huaiyu

“…Pharmacological activation of voltage-gated ion channels by ligands serves as the basis for therapy and mainly involves a classic gating mechanism that…”
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‘C-type’ closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel by Zhang, Qiansen, Fu, Jie, Zhang, Shaoying, Guo, Peipei, Liu, Shijie, Shen, Juwen, Guo, Jiangtao, Yang, Huaiyu, Yao, Xuebiao

“…ABSTRACT Two-pore domain potassium (K2P) channels gate primarily within the selectivity filter, termed ‘C-type’ gating. Due to the lack of structural insights…”
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Preservation of DNA Nanostructure Carriers: Effects of Freeze–Thawing and Ionic Strength during Lyophilization and Storage by Zhu, Bing, Zhao, Yan, Dai, Jiangbing, Wang, Jianbang, Xing, Shu, Guo, Linjie, Chen, Nan, Qu, Xiangmeng, Li, Li, Shen, Juwen, Shi, Jiye, Li, Jiang, Wang, Lihua

“…DNA nanostructures have attracted wide interest in biomedical applications, especially as nanocarriers for drug delivery. Therefore, it is important to ensure…”
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Inside Cover: Valency‐Controlled Framework Nucleic Acid Signal Amplifiers (Angew. Chem. Int. Ed. 24/2018) by Liu, Qi, Ge, Zhilei, Mao, Xiuhai, Zhou, Guobao, Zuo, Xiaolei, Shen, Juwen, Shi, Jiye, Li, Jiang, Wang, Lihua, Chen, Xiaoqing, Fan, Chunhai

“…Ultrasensitive biosensing is made possible by a framework nucleic acids (FNA)‐programmed strategy, designed to develop valence‐controlled signal amplifiers…”
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Valency‐Controlled Framework Nucleic Acid Signal Amplifiers by Liu, Qi, Ge, Zhilei, Mao, Xiuhai, Zhou, Guobao, Zuo, Xiaolei, Shen, Juwen, Shi, Jiye, Li, Jiang, Wang, Lihua, Chen, Xiaoqing, Fan, Chunhai

“…Weak ligand–receptor recognition events are often amplified by recruiting multiple regulatory biomolecules to the action site in biological systems. However,…”
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Innentitelbild: Valency‐Controlled Framework Nucleic Acid Signal Amplifiers (Angew. Chem. 24/2018) by Liu, Qi, Ge, Zhilei, Mao, Xiuhai, Zhou, Guobao, Zuo, Xiaolei, Shen, Juwen, Shi, Jiye, Li, Jiang, Wang, Lihua, Chen, Xiaoqing, Fan, Chunhai

“…Programmierte Gerüstnukleinsäuren (FNAs) sind Teil einer Strategie für die Entwicklung valenzkontrollierter Signalverstärker mit hoher Modularität für die hoch…”
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Innentitelbild: Valency‐Controlled Framework Nucleic Acid Signal Amplifiers by Liu, Qi, Ge, Zhilei, Mao, Xiuhai, Zhou, Guobao, Zuo, Xiaolei, Shen, Juwen, Shi, Jiye, Jiang, Li, Wang, Lihua, Chen, Xiaoqing, Fan, Chunhai

“…Programmierte Gerüstnukleinsäuren (FNAs) sind Teil einer Strategie für die Entwicklung valenzkontrollierter Signalverstärker mit hoher Modularität für die hoch…”
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