Search Results - "Shen, Huiyong"
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Artificial cells from microfluidic electrospray for reactive oxygen species scavenging
Published in Materials & design (01-10-2023)“…[Display omitted] •Microcapsules with an enzyme-based reactive oxygen species (ROS) elimination system were developed by microfluidic electrospray…”
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Single-cell RNA sequencing analysis of human bone-marrow-derived mesenchymal stem cells and functional subpopulation identification
Published in Experimental & molecular medicine (01-04-2022)“…Mesenchymal stem cells (MSCs) are a common kind of multipotent cell in vivo, but their heterogeneity limits their further applications. To identify MSC…”
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LncRNA‐OG Promotes the Osteogenic Differentiation of Bone Marrow‐Derived Mesenchymal Stem Cells Under the Regulation of hnRNPK
Published in Stem cells (Dayton, Ohio) (01-02-2019)“…Bone marrow‐derived mesenchymal stem cells (BM‐MSCs) are the main source of osteoblasts in vivo and are widely used in stem cell therapy. Previously, we…”
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ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway
Published in Journal of experimental & clinical cancer research (27-10-2021)“…The zinc transporters Zrt- and Irt-related protein (ZIP/SLC39) are overexpressed in human tumors and correlate with poor prognosis; however, their…”
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GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcoma
Published in Journal of orthopaedic surgery and research (07-12-2021)“…G2 and S phase-expressed-1 (GTSE1) negatively regulates the tumor-suppressive protein p53 and is potentially correlated with chemoresistance of cancer cells…”
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TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2
Published in Cell death and differentiation (01-12-2019)“…TNF receptor-associated factor 4 (TRAF4), a member of the TRAF family, plays an important role in the embryogenesis and development of the bone system…”
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Abnormal inhibition of osteoclastogenesis by mesenchymal stem cells through the miR-4284/CXCL5 axis in ankylosing spondylitis
Published in Cell death & disease (25-02-2019)“…Ankylosing spondylitis (AS) is a common inflammatory autoimmune disease, characterized by pathological osteogenesis. Mesenchymal stem cells (MSCs), as the main…”
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The N 6-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6
Published in Cell death & disease (04-06-2021)“…Abstract N 6-methyladenosine (m6A) modification is widespread in messenger RNAs and increasing evidence suggests the crucial roles of m6A in cell…”
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Correction: GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation
Published in eLife (25-04-2024)Get full text
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Enhanced osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis: a study based on a three-dimensional biomimetic environment
Published in Cell death & disease (25-04-2019)“…The mechanism of pathological osteogenesis in Ankylosing spondylitis (AS) is largely unknown. Our previous studies demonstrated that the imbalance between…”
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TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis
Published in Nature communications (10-09-2021)“…Ankylosing spondylitis (AS) is a type of rheumatic disease characterized by chronic inflammation and pathological osteogenesis in the entheses. Previously, we…”
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Interleukin-6/interleukin-6 receptor complex promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells
Published in Stem cell research & therapy (22-01-2018)“…Interleukin-6 (IL-6) with IL-6 receptor (IL-6R) play an important role in the tissue regeneration in vivo, especially bone metabolism. Bone marrow -derived…”
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Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation
Published in Nature communications (06-09-2018)“…Emerging evidence has revealed that Nestin not only serves as a biomarker for multipotent stem cells, but also regulates cell proliferation and invasion in…”
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MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells
Published in Biochemical and biophysical research communications (24-08-2012)“…► RKIP is a repressor of stromal genes required for tumor metastasis. ► MiRNA-224 upregulation correlates with RKIP downregulation in breast cancer cells. ►…”
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ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression
Published in Experimental & molecular medicine (01-08-2023)“…Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely…”
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Galangin mitigates glucocorticoid-induced osteoporosis by activating autophagy of BMSCs via triggering the PKA/CREB signaling pathway
Published in Acta biochimica et biophysica Sinica (01-08-2023)“…Glucocorticoid-induced osteoporosis (GIOP), one of the most common and serious adverse effects associated with glucocorticoid administration, manifests as…”
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Autophagy enhances mesenchymal stem cell-mediated CD4 + T cell migration and differentiation through CXCL8 and TGF-β1
Published in Stem cell research & therapy (23-08-2019)“…Mesenchymal stem cells (MSCs) have been recognized as a promising tool for the treatment of various inflammatory disorders and autoimmune diseases. Stress…”
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GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation
Published in eLife (02-10-2020)“…Osteoporosis is a common systemic skeletal disorder resulting in bone fragility and increased fracture risk. It is still necessary to explore its detailed…”
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Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis
Published in Arthritis research & therapy (14-09-2020)“…Abstract Background A few months ago, the Bioscience Reports journal showed that growth differentiation factor 5 (GDF5) rs143383 genetic polymorphism increases…”
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