Search Results - "Shen, Huaizong"

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins by Shen Huaizong, Liu Dongliang, Wu, Kun, Lei Jianlin, Nieng, Yan

“…Targeting sodium channelsVoltage-gated sodium (Nav) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these…”
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Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution by Shen, Huaizong, Zhou, Qiang, Pan, Xiaojing, Li, Zhangqiang, Wu, Jianping, Yan, Nieng

“…Voltage-gated sodium (Na ) channels are responsible for the initiation and propagation of action potentials. They are associated with a variety of…”
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Structural basis for the modulation of voltage-gated sodium channels by animal toxins by Shen, Huaizong, Li, Zhangqiang, Jiang, Yan, Pan, Xiaojing, Wu, Jianping, Cristofori-Armstrong, Ben, Smith, Jennifer J, Chin, Yanni K Y, Lei, Jianlin, Zhou, Qiang, King, Glenn F, Yan, Nieng

“…Animal toxins that modulate the activity of voltage-gated sodium (Na ) channels are broadly divided into two categories-pore blockers and gating modifiers. The…”
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Structure of the Nav1.4-β1 Complex from Electric Eel by Yan, Zhen, Zhou, Qiang, Wang, Lin, Wu, Jianping, Zhao, Yanyu, Huang, Gaoxingyu, Peng, Wei, Shen, Huaizong, Lei, Jianlin, Yan, Nieng

“…Voltage-gated sodium (Nav) channels initiate and propagate action potentials. Here, we present the cryo-EM structure of EeNav1.4, the Nav channel from electric…”
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Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA by Pan Xiaojing, Li Zhangqiang, Huang Xiaoshuang, Huang Gaoxingyu, Gao Shuai, Shen Huaizong, Liu, Lei, Lei Jianlin, Nieng, Yan

“…Targeting sodium channelsVoltage-gated sodium (Nav) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these…”
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Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1 by Pan Xiaojing, Li Zhangqiang, Zhou, Qiang, Shen Huaizong, Wu, Kun, Huang Xiaoshuang, Chen Jiaofeng, Zhang Juanrong, Zhu Xuechen, Lei Jianlin, Xiong, Wei, Gong Haipeng, Xiao Bailong, Nieng, Yan

“…Structures of voltage-gated sodium channelsIn “excitable” cells, like neurons and muscle cells, a difference in electrical potential is used to transmit…”
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Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs by Li, Tian, Wu, Kun, Yue, Zhenlei, Wang, Yifei, Zhang, Fan, Shen, Huaizong

“…Among the five KCNQ channels, also known as the Kv7 voltage-gated potassium (Kv) channels, KCNQ2–KCNQ5 control neuronal excitability. Dysfunctions of…”
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Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2 by Peng, Wei, Shen, Huaizong, Wu, Jianping, Guo, Wenting, Pan, Xiaojing, Wang, Ruiwu, Chen, S. R. Wayne, Yan, Nieng

“…RyR2 is a high-conductance intracellular calcium (Ca ) channel that controls the release of Ca from the sarco(endo)plasmic reticulum of a variety of cells…”
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Structure of the human Meckel-Gruber protein Meckelin by Liu, Dongliang, Qian, Dandan, Shen, Huaizong, Gong, Deshun

“…Mutations in the gene account for most cases of the Meckel-Gruber syndrome, the most severe ciliopathy with a 100% mortality rate. Here, we report a 3.3-Å…”
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Structural basis for Gemin5 decamer-mediated mRNA binding by Guo, Qiong, Zhao, Shidong, Francisco-Velilla, Rosario, Zhang, Jiahai, Embarc-Buh, Azman, Abellan, Salvador, Lv, Mengqi, Tang, Peiping, Gong, Qingguo, Shen, Huaizong, Sun, Linfeng, Yao, Xuebiao, Min, Jinrong, Shi, Yunyu, Martínez-Salas, Encarnacion, Zhang, Kaiming, Xu, Chao

“…Gemin5 in the Survival Motor Neuron (SMN) complex serves as the RNA-binding protein to deliver small nuclear RNAs (snRNAs) to the small nuclear…”
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Structures of human Na v 1.7 channel in complex with auxiliary subunits and animal toxins by Shen, Huaizong, Liu, Dongliang, Wu, Kun, Lei, Jianlin, Yan, Nieng

“…Voltage-gated sodium channel Na 1.7 represents a promising target for pain relief. Here we report the cryo-electron microscopy structures of the human Na…”
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High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV by Huang, Gaoxingyu, Liu, Dongliang, Wang, Weipeng, Wu, Qiurong, Chen, Jiaofeng, Pan, Xiaojing, Shen, Huaizong, Yan, Nieng

“…Nav1.7 represents a preeminent target for next-generation analgesics for its critical role in pain sensation. Here we report a 2.2-Å resolution cryo-EM…”
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Structural insights into ion selectivity and transport mechanisms of Oryza sativa HKT2;1 and HKT2;2/1 transporters by Wang, Xiaohui, Shen, Xiaoshuai, Qu, Yannan, Zhang, Heng, Wang, Chu, Yang, Fan, Shen, Huaizong

“…Plant high-affinity K + transporters (HKTs) play a pivotal role in maintaining the balance of Na + and K + ions in plants, thereby influencing plant growth…”
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Molecular basis for pore blockade of human Na + channel Na v 1.2 by the μ-conotoxin KIIIA by Pan, Xiaojing, Li, Zhangqiang, Huang, Xiaoshuang, Huang, Gaoxingyu, Gao, Shuai, Shen, Huaizong, Liu, Lei, Lei, Jianlin, Yan, Nieng

“…The voltage-gated sodium channel Na 1.2 is responsible for the initiation and propagation of action potentials in the central nervous system. We report the…”
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Structure of the human voltage-gated sodium channel Na v 1.4 in complex with β1 by Pan, Xiaojing, Li, Zhangqiang, Zhou, Qiang, Shen, Huaizong, Wu, Kun, Huang, Xiaoshuang, Chen, Jiaofeng, Zhang, Juanrong, Zhu, Xuechen, Lei, Jianlin, Xiong, Wei, Gong, Haipeng, Xiao, Bailong, Yan, Nieng

“…Voltage-gated sodium (Na ) channels, which are responsible for action potential generation, are implicated in many human diseases. Despite decades of rigorous…”
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High-resolution structures of human Na v 1.7 reveal gating modulation through α-π helical transition of S6 IV by Huang, Gaoxingyu, Liu, Dongliang, Wang, Weipeng, Wu, Qiurong, Chen, Jiaofeng, Pan, Xiaojing, Shen, Huaizong, Yan, Nieng

“…Na 1.7 represents a preeminent target for next-generation analgesics for its critical role in pain sensation. Here we report a 2.2-Å resolution cryo-EM…”
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Structure and engineering of miniature Acidibacillus sulfuroxidans Cas12f1 by Wu, Zhaowei, Liu, Dongliang, Pan, Deng, Yu, Haopeng, Shi, Jin, Ma, Jiacheng, Fu, Wenhan, Wang, Zhipeng, Zheng, Zijie, Qu, Yannan, Li, Fan, Chen, Weizhong, Huang, Xingxu, Shen, Huaizong, Ji, Quanjiang

“…The miniature CRISPR-Cas12f nucleases enable efficient delivery via cargo-size-limited vehicles, thereby showing promise for in vivo therapeutic applications…”
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Structure of the Na v 1.4-β1 Complex from Electric Eel by Yan, Zhen, Zhou, Qiang, Wang, Lin, Wu, Jianping, Zhao, Yanyu, Huang, Gaoxingyu, Peng, Wei, Shen, Huaizong, Lei, Jianlin, Yan, Nieng

“…Voltage-gated sodium (Na ) channels initiate and propagate action potentials. Here, we present the cryo-EM structure of EeNa 1.4, the Na channel from electric…”
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