Search Results - "Shen, Helena"
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Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
Published in Nature (London) (18-11-2021)“…The majority of oncogenic drivers are intracellular proteins, thus constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented…”
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Targeting of intracellular oncoproteins with peptide-centric CARs
Published in Nature (London) (23-11-2023)“…The majority of oncogenic drivers are intracellular proteins, constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented by…”
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Journal Article -
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Abstract 1493: Discovery and CAR T targeting of lineage-restricted neuroblastoma oncoproteins
Published in Cancer research (Chicago, Ill.) (01-07-2021)“…Abstract Background: The MHC presents a snapshot of the intracellular proteome for surveillance by T cells, including peptides from mutated proteins…”
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Retraction Note: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
Published in Nature (London) (23-11-2023)“…Following the publication of our manuscript, a new high-resolution structure of the HLA-A·24:02/PHOX2B peptide/10LH scFv complex by X-ray crystallography…”
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RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
Published in Nature (London) (18-11-2021)“…The majority of oncogenic drivers are intracellular proteins, thus constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented…”
Get full text
Journal Article