Search Results - "Shen, Ancheng"

Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway by Ding, Chunyong, Song, Zilan, Shen, Ancheng, Chen, Tingting, Zhang, Ao

“…Multiple cancer immunotherapies including chimeric antigen receptor T cell and immune checkpoint inhibitors (ICIs) have been successfully developed to treat…”
Get full text

A novel STING agonist with systemic and durable anti‐tumour activity by Wang, Xiyuan, Shen, Ancheng, Zhang, Yan, Chen, Xiaoxu, Ding, Jian, Zhang, Ao, Geng, Meiyu, Ding, Chunyong, Xie, Zuoquan

“…Background Stimulator of interferon genes (STING) has emerged as a crucial and promising target in tumor immunotherapy in recent years. Its agonists play a…”
Get full text

Recent advances in the development of STING inhibitors: an updated patent review by Shen, Ancheng, Chen, Mingjie, Chen, Qingxuan, Liu, Zhiguo, Zhang, Ao

“…STING is at the center of the cGAS-STING signaling and acts as the hub of the innate immune system. Hyper-activation of STING has been observed in various…”
Get more information

Structure–Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists by Song, Zilan, Wang, Xiyuan, Zhang, Yan, Gu, Wangting, Shen, Ancheng, Ding, Chunyong, Li, Han, Xiao, Ruoxuan, Geng, Meiyu, Xie, Zuoquan, Zhang, Ao

“…Activation of the stimulator of interferon gene (STING) has emerged as an exciting immuno-oncology therapeutic strategy; however, the first-generation STING…”
Get full text

Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[d]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD) by Zeng, Ruoqing, Fang, Meimiao, Shen, Ancheng, Chai, Xiaolei, Zhao, Yumiao, Liu, Mingyao, Zhu, Lingfeng, Rui, Weiwei, Feng, Bo, Hong, Liang, Ding, Chunyong, Song, Zilan, Lu, Weiqiang, Zhang, Ao

“…Accumulating evidence has demonstrated a critical pathological role of oxysterol receptor GPR183 in various inflammatory and autoimmune diseases, including…”
Get full text

Structure−Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists by Shen, Ancheng, Li, Xiyuan, Zhang, Yan, Ma, Jing, Xiao, Ruoxuan, Wang, Xiyuan, Song, Zilan, Liu, Zhiguo, Geng, Meiyu, Zhang, Ao, Xie, Zuoquan, Ding, Chunyong

“…Pharmacological activation of stimulator of interferon genes (STING) by agonists has emerged as a new modality of cancer immunotherapy. However, current…”
Get full text

Discovery of β-cyclocitral-derived mono-carbonyl curcumin analogs as anti-hepatocellular carcinoma agents via suppression of MAPK signaling pathway by Han, Haoyi, Alsayed, Ali Mohammed Mohammed, Wang, Yi, Yan, Qi, Shen, Ancheng, Zhang, Jianxia, Ye, Yanfei, Liu, Zhiguo, Wang, Kun, Zheng, Xiaohui

“…[Display omitted] •A series of β-cyclocitral-derived mono-carbonyl curcumin analogs are synthesized.•A19 significantly inhibits cell proliferation and induces…”
Get full text

A Concerted Catalytic System for Sonogashira Coupling Reactions: Combination of N‐Heterocyclic Carbene Palladium and Copper Complexes by Shen, Ancheng, Wu, Zhen, Fang, Yue, Yang, Jinming, Zhu, Haibo, Tu, Tao

“…Robust acenaphthoimidazolylidene palladium complexes have been demonstrated as highly efficient and general catalysts for Sonogashira cross‐coupling reactions…”
Get full text

Physical formula enhanced multi-task learning for pharmacokinetics prediction by Li, Ruifeng, Zhou, Dongzhan, Shen, Ancheng, Zhang, Ao, Su, Mao, Li, Mingqian, Chen, Hongyang, Chen, Gang, Zhang, Yin, Zhang, Shufei, Li, Yuqiang, Ouyang, Wanli

“…Artificial intelligence (AI) technology has demonstrated remarkable potential in drug dis-covery, where pharmacokinetics plays a crucial role in determining…”
Get full text