Search Results - "Shema, Kristen"

Tunable Blood Shunt for Neonates With Complex Congenital Heart Defects by Garven, Ellen, Rodell, Christopher B, Shema, Kristen, Govender, Krianthan, Cassel, Samantha E, Ferrick, Bryan, Kupsho, Gabriella, Kung, Ethan, Spiller, Kara L, Stevens, Randy, Throckmorton, Amy L

“…Despite advancements in procedures and patient care, mortality rates for neonatal recipients of the Norwood procedure, a palliation for single ventricle…”
Get full text

Abstract 2892: Development of claudin 6 bispecific antibodies for treatment of ovarian cancer by Rucker, Joseph, Doolan, Kyle, Tyrell, Breanna, Lobley, Anna, Molino, Nick, Shema, Kristen, Guldner, Kyle, Cunningham, Alyssa, Chambers, Ross, Payne, Riley

“…Abstract There is growing interest in applying antibody modalities including bispecifics, antibody-drug conjugates, and CART to solid tumors. However,…”
Get full text

Abstract 1865: Development of CTIM-76, a highly specific Claudin 6 bispecific antibody for treatment of ovarian cancer by Rucker, Joseph, Sanchez, Ileine, Doolan, Kyle, Tyrell, Breanna, Lobley, Anna, Molino, Nicholas, Shema, Kristen, Guldner, Kyle, Roth, Hayley, Cunningham, Alyssa, Slovik, Kate, Payne, Riley, Butz, Eric, Dick, Evan, Calamai, Edward, Chambers, Ross

“…Abstract Solid tumors lead to 580,000 deaths annually in the US, and safe and effective therapeutics for many late-stage solid tumors are lacking. Ovarian…”
Get full text

Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point by Screnci, Brad, Stafford, Lewis J., Barnes, Trevor, Shema, Kristen, Gilman, Samantha, Wright, Rebecca, Al Absi, Suzie, Phillips, Tim, Azuelos, Charles, Slovik, Katherine, Murphy, Paige, Harmon, Daniel B., Charpentier, Tom, Doranz, Benjamin J., Rucker, Joseph B., Chambers, Ross

“…The tight junction protein claudin 6 (CLDN6) is differentially expressed on cancer cells with almost no expression in healthy tissue. However, achieving…”
Get full text

Abstract 318: Atomic-level specificity of Claudin 6 monoclonal antibodies isolated for treating solid tumors by Screnci, Brad, Stafford, Lewis J., Barnes, Trevor, Shema, Kristen, Gilman, Samantha, Rimkunas, Rebecca, Absi, Suzie Al, Phillips, Tim, Azuelos, Charles, Slovik, Katherine, Muprhy, Paige, Harmon, Daniel B., Charpentier, Tom, Doranz, Benjamin J., Rucker, Joseph B., Chambers, Ross

“…Abstract The tight junction protein Claudin 6 (CLDN6) is differentially expressed on cancer cells with almost no expression in healthy tissue, making it a…”
Get full text

Abstract 317: Isolation of highly selective antibodies against claudin 18.2 for the treatment of solid tumors by Screnci, Brad, Barnes, Trevor, Shema, Kristen, Rimkunas, Rebecca, Kannan, Shruthi, Phillips, Tim, Navia, Carmen, Azuelos, Charles, Charpentier, Tom, Houtmann, Jennifer, Miller, Lisa, Stafford, Lewis J., Doranz, Benjamin J., Rucker, Joseph B., Chambers, Ross

“…Abstract Monoclonal antibodies (MAbs) are a well-established treatment approach in oncology and other diseases. Nevertheless, many multipass membrane proteins…”
Get full text

Abstract 6305: Bispecific claudin 18.2 and GPRC5D antibodies with potent cell-killing activity for cancer therapeutics by Sanchez, Ileine, Roth, Hayley, Screnci, Brad, Tucker, David, Molino, Nick, Barnes, Trevor, Murphy, Paige, Guldner, Kyle, Phillips, Tim, Shema, Kristen, Charpentier, Thomas, Cunningham, Alyssa, Latta, Janae, Tyrell, Breanna, Pitts, Meghan, Navia, Carmen, Azuelos, Charles, Lobley, Anna, Karam, Jawhara, Fiers, Valerie, Reyes, Daniela, Slovik, Kate, Snyder, Alison, Assogba, Marianne, Chang, Kai-Ti, Payne, Riley, Doolan, Kyle, Chambers, Ross, Rucker, Joe, Doranz, Benjamin

“…Abstract Tumor-associated antigens with little or no expression in healthy tissue are attractive targets for anti-tumor modalities including T cell-engaging…”
Get full text

Abstract 1543: Discovery of CCR8 antibodies targeting regulatory T cells to enable tumor sensitization by Screnci, Brad, Roth, Hayley, Campbell, Sarah, Tucker, David, Fenn-Ulke, Colleen, Rosenberg, Erin, Pitts, Meghan, Saint-Jean, Naomi, Karam, Jawhara, Murphy, Paige, Reyes, Daniela, Latta, Janae, Guldner, Kyle, Gilman, Samantha, Phillips, Tim, Stafford, L. Joe, Tyrell, Breanna, Shema, Kristen, Sulli, Chidananda, Molino, Nick, Snyder, Allison, Assogba, Marianne, Shah, Janvi, Zimmerman, McKayla, Barnes, Trevor, Payne, Riley, Cunningham, Alyssa, Charrier, Elisabeth, Ohl, Holden, Doolan, Kyle, Sanchez, Ileine, Rucker, Joseph B., Chambers, Ross, Doranz, Benjamin

“…Abstract Regulatory T (Treg) cells in the tumor microenvironment have an immune suppressive function, and their presence is associated with poor prognosis…”
Get full text