Search Results - "Shelton, Richard"

Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis by Wang, Qingzhong, Shelton, Richard C., Dwivedi, Yogesh

“…Gene-environment interaction contributes to the risks of psychiatric disorders. Interactions between FKBP5 gene variants and early-life stress may enhance the…”
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DNA methylation and expression of stress related genes in PBMC of MDD patients with and without serious suicidal ideation by Roy, Bhaskar, Shelton, Richard C, Dwivedi, Yogesh

“…Abstract Stress plays an important role in major depressive disorder (MDD) and is one of the state dependent factors in suicidal behavior. A dysfunctional…”
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Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder by Roy, Bhaskar, Dunbar, Michael, Shelton, Richard C, Dwivedi, Yogesh

“…Major depressive disorder (MDD) is predicted to be the second leading cause of global disease burden by 2030. A large number of MDD patients do not respond to…”
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Role of Complex Epigenetic Switching in Tumor Necrosis Factor-α Upregulation in the Prefrontal Cortex of Suicide Subjects by Wang, Qingzhong, Roy, Bhaskar, Turecki, Gustavo, Shelton, Richard C, Dwivedi, Yogesh

“…Objective:Proinflammatory cytokines have recently received considerable attention for their role in suicidal behavior; however, how the expression of cytokine…”
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Functional Biomarkers of Depression: Diagnosis, Treatment, and Pathophysiology by SCHMIDT, Heath D, SHELTON, Richard C, DUMAN, Ronald S

“…Major depressive disorder (MDD) is a heterogeneous illness for which there are currently no effective methods to objectively assess severity, endophenotypes,…”
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Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study by Popova, Vanina, Daly, Ella J, Trivedi, Madhukar, Cooper, Kimberly, Lane, Rosanne, Lim, Pilar, Mazzucco, Christine, Hough, David, Thase, Michael E, Shelton, Richard C, Molero, Patricio, Vieta, Eduard, Bajbouj, Malek, Manji, Husseini, Drevets, Wayne C, Singh, Jaskaran B

“…About one-third of patients with depression fail to achieve remission despite treatment with multiple antidepressants. This study compared the efficacy and…”
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Ketamine for acute suicidal ideation. An emergency department intervention: A randomized, double‐blind, placebo‐controlled, proof‐of‐concept trial by Domany, Yoav, Shelton, Richard C., McCullumsmith, Cheryl B.

“…Background Depressed patients presenting to emergency departments with acute suicidal ideation are a major public health concern. Ketamine, a rapidly acting…”
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Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial by Daly, Ella J, Singh, Jaskaran B, Fedgchin, Maggie, Cooper, Kimberly, Lim, Pilar, Shelton, Richard C, Thase, Michael E, Winokur, Andrew, Van Nueten, Luc, Manji, Husseini, Drevets, Wayne C

“…Approximately one-third of patients with major depressive disorder (MDD) do not respond to available antidepressants. To assess the efficacy, safety, and…”
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Strong associations of telomere length and mitochondrial copy number with suicidality and abuse history in adolescent depressed individuals by Ochi, Shinichiro, Roy, Bhaskar, Prall, Kevin, Shelton, Richard C., Dwivedi, Yogesh

“…Major depressive disorder (MDD) is highly prevalent in adolescents and is a major risk factor for suicidality. Recent evidence shows that accelerated cellular…”
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Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression by Shelton, Richard C, Miller, Andrew H

“…Obesity and related metabolic conditions are of epidemic proportions in most of the world, affecting both adults and children. The accumulation of lipids in…”
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Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial by Daly, Ella J, Trivedi, Madhukar H, Janik, Adam, Li, Honglan, Zhang, Yun, Li, Xiang, Lane, Rosanne, Lim, Pilar, Duca, Anna R, Hough, David, Thase, Michael E, Zajecka, John, Winokur, Andrew, Divacka, Ilona, Fagiolini, Andrea, Cubala, Wieslaw J, Bitter, István, Blier, Pierre, Shelton, Richard C, Molero, Patricio, Manji, Husseini, Drevets, Wayne C, Singh, Jaskaran B

“…Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established. To…”
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A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression by Singh, Jaskaran B., Fedgchin, Maggie, Daly, Ella J., De Boer, Peter, Cooper, Kimberly, Lim, Pilar, Pinter, Christine, Murrough, James W., Sanacora, Gerard, Shelton, Richard C., Kurian, Benji, Winokur, Andrew, Fava, Maurizio, Manji, Husseini, Drevets, Wayne C., Van Nueten, Luc

“…Objective:Ketamine, an N-methyl-d-aspartate glutamate receptor antagonist, has demonstrated a rapid-onset antidepressant effect in patients with…”
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Impact of pharmacogenomics on clinical outcomes in major depressive disorder in the GUIDED trial: A large, patient- and rater-blinded, randomized, controlled study by Greden, John F., Parikh, Sagar V., Rothschild, Anthony J., Thase, Michael E., Dunlop, Boadie W., DeBattista, Charles, Conway, Charles R., Forester, Brent P., Mondimore, Francis M., Shelton, Richard C., Macaluso, Matthew, Li, James, Brown, Krystal, Gilbert, Alexa, Burns, Lindsey, Jablonski, Michael R., Dechairo, Bryan

“…Current prescribing practices for major depressive disorder (MDD) produce limited treatment success. Although pharmacogenomics may improve outcomes by…”
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Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis by Fournier, Jay C, DeRubeis, Robert J, Hollon, Steven D, Dimidjian, Sona, Amsterdam, Jay D, Shelton, Richard C, Fawcett, Jan

“…CONTEXT Antidepressant medications represent the best established treatment for major depressive disorder, but there is little evidence that they have a…”
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Comparison of obturation quality in natural and replica teeth root-filled using different sealers and techniques by Kooanantkul, Chuta, Shelton, Richard M, Camilleri, Josette

“…Objectives This study aims to assess the obturation efficacy of sealers placed with different techniques using microcomputed tomography (µCT) and assess the…”
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The effect of IV ketamine in patients with major depressive disorder and elevated features of borderline personality disorder by Chen, Kelly S., Dwivedi, Yogesh, Shelton, Richard C.

“…Comorbid borderline personality disorder and major depressive disorder is common and often not adequately responsive to standard antidepressant therapies…”
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Depression, Antidepressants, and Weight Gain in Children by Shelton, Richard C.

“…[...]there is strong evidence that antipsychotics are associated with weight gain and metabolic disease in children (3). (5) in this issue of Obesity have…”
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Leaching and cytotoxicity of bismuth oxide in ProRoot MTA – A laboratory investigation by Pelepenko, Lauter E., Marciano, Marina A., Shelton, Richard M., Camilleri, Josette

“…Aim The present study examined the leaching and cytotoxicity of bismuth from ProRoot MTA and aimed to identify whether bismuth leaching was affected by the…”
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Obesity, inflammation, and depression in adolescents by McLachlan, Caleb, Shelton, Richard, Li, Li

“…The prevalence of depression and obesity among adolescents has markedly increased over the last few decades. A bidirectional relationship has been proposed…”
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Dental Pulp Stem Cell Mechanoresponsiveness: Effects of Mechanical Stimuli on Dental Pulp Stem Cell Behavior by Marrelli, Massimo, Codispoti, Bruna, Shelton, Richard M, Scheven, Ben A, Cooper, Paul R, Tatullo, Marco, Paduano, Francesco

“…Dental pulp is known to be an accessible and important source of multipotent mesenchymal progenitor cells termed dental pulp stem cells (DPSCs). DPSCs can…”
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