Search Results - "Shelton, Patrick"

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex by Chen, James, Malone, Brandon, Llewellyn, Eliza, Grasso, Michael, Shelton, Patrick M.M., Olinares, Paul Dominic B., Maruthi, Kashyap, Eng, Edward T., Vatandaslar, Hasan, Chait, Brian T., Kapoor, Tarun M., Darst, Seth A., Campbell, Elizabeth A.

“…SARS-CoV-2 is the causative agent of the 2019–2020 pandemic. The SARS-CoV-2 genome is replicated and transcribed by the RNA-dependent RNA polymerase holoenzyme…”
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A wrench in the motor by Shelton, Patrick M. M., Kapoor, Tarun M.

“…Structural biology and resistance analyses reveal the binding mode and the basis for selective inhibition of the ATP synthase rotary motor protein by…”
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Force-dependent stimulation of RNA unwinding by SARS-CoV-2 nsp13 helicase by Mickolajczyk, Keith J., Shelton, Patrick M.M., Grasso, Michael, Cao, Xiaocong, Warrington, Sara E., Aher, Amol, Liu, Shixin, Kapoor, Tarun M.

“…The superfamily 1 helicase nonstructural protein 13 (nsp13) is required for SARS-CoV-2 replication. The mechanism and regulation of nsp13 has not been explored…”
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Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1–CoREST Complex by Dhall, Abhinav, Weller, Caroline E, Chu, Aurea, Shelton, Patrick M. M, Chatterjee, Champak

“…Lysine-specific demethylase 1 (LSD1) downregulates eukaryotic gene activity by demethylating mono- and dimethylated Lys4 in histone H3. Elucidating the…”
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Nucleosome Binding by the Lysine Specific Demethylase 1 (LSD1) Enzyme Enables Histone H3 Demethylation by Dhall, Abhinav, Shelton, Patrick M. M, Delachat, Aurore M.-F, Leonen, Calvin J. A, Fierz, Beat, Chatterjee, Champak

“…The essential human enzyme lysine specific demethylase 1 (LSD1) silences genes by demethylating mono- and dimethylated lysine 4 in histone H3 (H3K4me1/2)…”
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A Facile N-Mercaptoethoxyglycinamide (MEGA) Linker Approach to Peptide Thioesterification and Cyclization by Shelton, Patrick M M, Weller, Caroline E, Chatterjee, Champak

“…The C-terminal electrophilic activation of peptides by α-thioesterification requires strongly acidic conditions or complex chemical manipulations, which…”
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Using a Function-First “Scout Fragment”-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes by Ramsey, Jared R., Shelton, Patrick M. M., Heiss, Tyler K., Olinares, Paul Dominic B., Vostal, Lauren E., Soileau, Heather, Grasso, Michael, Casebeer, Sara W., Adaniya, Stephanie, Miller, Michael, Sun, Shan, Huggins, David J., Myers, Robert W., Chait, Brian T., Vinogradova, Ekaterina V., Kapoor, Tarun M.

“…Helicases, classified into six superfamilies, are mechanoenzymes that utilize energy derived from ATP hydrolysis to remodel DNA and RNA substrates. These…”
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Synthesis of guaipyridine alkaloids (±)-cananodine and (±)-rupestines D and G using an intramolecular Mizoroki-Heck reaction by Shelton, Patrick M.M., Grosslight, Samantha M., Mulligan, Briana J., Spargo, Hope V., Saad, Silvana S., Vyvyan, James R.

“…The guaipyridine alkaloids cananodine, rupestine D and rupestine G were synthesized in six steps or less from readily available…”
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A clickable glutamine (CliQ) derivative for the traceless reversible modification of peptides and proteins by Whedon, Samuel D, Parker, Marissa K, Tyson, Elizabeth L, Ritterhoff, Tobias, Shelton, Patrick M M, Chatterjee, Champak

“…The Cu(i)-mediated click reaction of proteins with affinity tags enables their selective isolation from complex mixtures. However, irreversible protein…”
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Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts by Leonen, Calvin Jon A, Shimada, Miho, Weller, Caroline E, Nakadai, Tomoyoshi, Hsu, Peter L, Tyson, Elizabeth L, Mishra, Arpit, Shelton, Patrick Mm, Sadilek, Martin, Hawkins, R David, Zheng, Ning, Roeder, Robert G, Chatterjee, Champak

“…The post-translational modification of histones by the small ubiquitin-like modifier (SUMO) protein has been associated with gene regulation, centromeric…”
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B-PO02-207 FIRST TRANSEPTAL PUNCTURE AFTER INTRA-ATRIAL SEPTAL SHUNT IMPLANT FOR ATRIAL FIBRILLATION ABLATION by Hantla, Jacob D., Sanford, Kirk, Shelton, Patrick, Raymond, Sophie, Tenison, Jennifer, Swarup, Vijendra

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Force-Dependent Stimulation of RNA Unwinding by SARS-CoV-2 NSP13 Helicase by Mickolajczyk, Keith J., Shelton, Patrick M., Grasso, Michael, Cao, Xiaocong, Warrington, Sara E., Aher, Amol, Liu, Shixin, Kapoor, Tarun M.

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Synthesis of cananodine by intramolecular epoxide opening by Shelton, Patrick, Ligon, Toby J., Dell (née Meyer), Jennifer M., Yarbrough, Loagan, Vyvyan, James R.

“…[Display omitted] •Guaipyridine alkaloid cananodine was synthesized in 6 steps.•7-Membered carbocycle was constructed using a remarkable intramolecular opening…”
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Chemical Approaches to Investigate the Biochemical Crosstalk between Histone Sumoylation, Methylation and Acetylation by Shelton, Patrick M. M

“…Histone post-translational modifications (PTM) within chromatin control many DNA-templated cellular processes, from DNA damage repair pathways to gene…”
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A Facile N‑Mercapto­ethoxy­glycinamide (MEGA) Linker Approach to Peptide Thioesterification and Cyclization by Shelton, Patrick M. M, Weller, Caroline E, Chatterjee, Champak

“…The C-terminal electrophilic activation of peptides by α-thioesterification requires strongly acidic conditions or complex chemical manipulations, which…”
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Teacher Leadership: Development and Research Based on Teacher Leader Model Standards by Shelton, Michael Patrick

“…Teacher leadership in schools has evolved many times as schools have looked to utilize teacher leaders in various ways to help support school organization,…”
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