Search Results - "Shelton, Lindsey B"

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies by Shelton, Lindsey B, Koren, 3rd, John, Blair, Laura J

“…The ATP-dependent 90 kDa heat shock protein, Hsp90, is a major regulator of protein triage, from assisting in nascent protein folding to refolding or degrading…”
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Hsp90 activator Aha1 drives production of pathological tau aggregates by Shelton, Lindsey B., Baker, Jeremy D., Zheng, Dali, Sullivan, Leia E., Solanki, Parth K., Webster, Jack M., Sun, Zheying, Sabbagh, Jonathan J., Nordhues, Bryce A., Koren, John, Ghosh, Suman, Blagg, Brian S. J., Blair, Laura J., Dickey, Chad A.

“…The microtubule-associated protein tau (MAPT, tau) forms neurotoxic aggregates that promote cognitive deficits in tauopathies, the most common of which is…”
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Human cyclophilin 40 unravels neurotoxic amyloids by Baker, Jeremy D, Shelton, Lindsey B, Zheng, Dali, Favretto, Filippo, Nordhues, Bryce A, Darling, April, Sullivan, Leia E, Sun, Zheying, Solanki, Parth K, Martin, Mackenzie D, Suntharalingam, Amirthaa, Sabbagh, Jonathan J, Becker, Stefan, Mandelkow, Eckhard, Uversky, Vladimir N, Zweckstetter, Markus, Dickey, Chad A, Koren, 3rd, John, Blair, Laura J

“…The accumulation of amyloidogenic proteins is a pathological hallmark of neurodegenerative disorders. The aberrant accumulation of the microtubule associating…”
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Reduction in Aha1 chaperone preserves hippocampal neurons and prevents tau‐related pathology in rTg4510 tau transgenic mice by Criado‐Marrero, Marangelie, Shelton, Lindsey B, Blair, Laura J.

“…Background Several molecular chaperones have been identified as important modulators of tau protein in aging and neurodegenerative illnesses like Alzheimer’s…”
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Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules by Martin, Mackenzie D, Baker, Jeremy D, Suntharalingam, Amirthaa, Nordhues, Bryce A, Shelton, Lindsey B, Zheng, Dali, Sabbagh, Jonathan J, Haystead, Timothy A.J, Gestwicki, Jason E, Dickey, Chad A

“…Three scaffolds with inhibitory activity against the heat shock protein 70 (Hsp70) family of chaperones have been found to enhance the degradation of the…”
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FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model by Criado-Marrero, Marangelie, Gebru, Niat T., Gould, Lauren A., Blazier, Danielle M., Vidal-Aguiar, Yamile, Smith, Taylor M., Abdelmaboud, Salma S., Shelton, Lindsey B., Wang, Xinming, Dahrendorff, Jan, Beaulieu-Abdelahad, David, Dickey, Chad A., Blair, Laura J.

“…Abnormal accumulation of hyperphosphorylated tau induces pathogenesis in neurodegenerative diseases, like Alzheimer’s disease. Molecular chaperones with…”
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O1‐06‐05: REGULATING TAU ACCUMULATION THROUGH CO‐CHAPERONES THAT ALTER HSP90 ATPASE ACTIVITY by Shelton, Lindsey B., Baker, Jeremy D., Blair, Laura J.

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REGULATING TAU ACCUMULATION THROUGH CO-CHAPERONES THAT ALTER HSP90 ATPASE ACTIVITY by Shelton, Lindsey B., Baker, Jeremy D., Blair, Laura J.

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PROLYL-ISOMERASES UNTANGLE TAU AGGREGATES AND PREVENT TAU PATHOLOGY by Baker, Jeremy D., Shelton, Lindsey B., Zheng, Dali, Dickey, Chad A., Blair, Laura J.

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P1‐231: PROLYL‐ISOMERASES UNTANGLE TAU AGGREGATES AND PREVENT TAU PATHOLOGY by Baker, Jeremy D., Shelton, Lindsey B., Zheng, Dali, Dickey, Chad A., Blair, Laura J.

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AHA1 ACCELERATES HSP90 ATPASE ACTIVITY TO DRIVE TAU AGGREGATION by Shelton, Lindsey B., Baker, Jeremy D., Zheng, Dali, Ghosh, Suman, Blagg, Brian S.J., Dickey, Chad A., Blair, Laura J.

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PPID CONTROLS TOXIC AMYLOID FORMATION THROUGH PROLINE ISOMERIZATION by Baker, Jeremy D., Shelton, Lindsey B., Zheng, Dali, Blair, Laura J., Koren, John, Zweckstetter, Markus, Dickey, Chad A.

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